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Journal:
Article Title: Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis
doi: 10.1172/JCI13055
Figure Lengend Snippet: Impacts of the implantation of WT mouse– or AT1a–/– mouse–derived MNCs into the ischemic hindlimbs of AT1a–/– mice on angiogenesis. The impaired LDBF ratio in AT1a–/– mice was partially but significantly restored after implantation of WT mouse–derived MNCs into the ischemic hindlimb of AT1a–/– mice (P < 0.01 vs. AT1a–/–). In contrast, implantation of AT1a–/– mouse–derived MNCs slightly improved the LDBF ratio in AT1a–/– mice, but the difference was not significant (vs. AT1a–/–). Neutralizing anti-VEGF mAb treatment abolished the WT-MNC–mediated rescue of impaired angiogenesis in AT1a–/– mice (P = NS vs. AT1a–/–).
Article Snippet: In five additional mice, neutralizing
Techniques: Derivative Assay