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CH Instruments
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Hawkins Inc
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Image Search Results
Journal: Biochemical pharmacology
Article Title: Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice
doi: 10.1016/j.bcp.2018.08.018
Figure Lengend Snippet: Intestinal permeability and stability of valacyclovir during in situ jejunal perfusions of prodrug in wildtype and Bphl knockout (KO) mice. (A) Effective permeability of 50 μM valacyclovir in both genotypes, and (B) acyclovir concentrations in the outlet perfusate of both genotypes as a function of time. Data are expressed as mean ± SE (n=3–4). (C) Percent ofvalacyclovir and acyclovir found in the portal vein blood, at 5 and 30 min, following jejunal perfusions of 50 μM valacyclovir. Data are expressed as mean ± SE (n=3). *p ≤ 0.05, as compared to wildtype mice, using an unpaired t-test.
Article Snippet: Valacyclovir-D4 and
Techniques: Permeability, In Situ, Knock-Out
Journal: Biochemical pharmacology
Article Title: Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice
doi: 10.1016/j.bcp.2018.08.018
Figure Lengend Snippet: Plasma concentration-time profile of acyclovir (ACV) and valacyclovir (VACV) after (A) intravenous and (B) oral administrations of 25 nmol/g valacyclovir in wildtype (WT) and Bphl knockout (KO) mice. Data are expressed as mean ± SE (n=3) in which the y-axis is displayed on a linear scale (left-sided panels) and on a logarithmic scale (right-sided panels).
Article Snippet: Valacyclovir-D4 and
Techniques: Concentration Assay, Knock-Out
Journal: Biochemical pharmacology
Article Title: Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice
doi: 10.1016/j.bcp.2018.08.018
Figure Lengend Snippet: Pharmacokinetic Parameters of Valacyclovir and Acyclovir in Wildtype and Bphl Knockout Mice after the Oral and Intravenous Administrations of 25 nmoL/g Valacyclovir
Article Snippet: Valacyclovir-D4 and
Techniques: Knock-Out
Journal: Journal of pharmaceutical sciences
Article Title: Evaluation of Active and Passive Transport Processes in Corneas Extracted from Preserved Rabbit Eyes
doi: 10.1002/jps.21979
Figure Lengend Snippet: Transcorneal permeability of acyclovir and quinidine across corneas from eyes preserved in phosphate buffered saline (PBS) over wet ice for 24h compared with freshly excised rabbit corneas. The studies were conducted at 34°C. Results are depicted a mean ± SD (n=3). * p<0.05
Article Snippet:
Techniques: Permeability, Saline