abcb1 Search Results


gene exp abcb1 hs01067802 m1  (Thermo Fisher)
90
Thermo Fisher gene exp abcb1 hs01067802 m1
Gene Exp Abcb1 Hs01067802 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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anticd243 abcb1 antibody  (Miltenyi Biotec)
93
Miltenyi Biotec anticd243 abcb1 antibody
Anticd243 Abcb1 Antibody, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp abcb1 hs00184491 m1  (Thermo Fisher)
98
Thermo Fisher gene exp abcb1 hs00184491 m1
Gene Exp Abcb1 Hs00184491 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 98 stars, based on 1 article reviews
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mdr 1  (Proteintech)
96
Proteintech mdr 1
Mdr 1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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snp abcb1 c 7586657 20  (Thermo Fisher)
99
Thermo Fisher snp abcb1 c 7586657 20
Snp Abcb1 C 7586657 20, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp abcb1 hs00184500 m1  (Thermo Fisher)
99
Thermo Fisher gene exp abcb1 hs00184500 m1
Gene Exp Abcb1 Hs00184500 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
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antibodies against mdr1  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc antibodies against mdr1
Western blotting analysis of ABCB1 ( <t>MDR1</t> ), ABCC1 ( MRP1 ) and Hsp70 in Caco-2 cells. ( A ) Representative immunoblotting images demonstrate the effect of IC 50 dose of ATRA, EC19, and EC23 on the expression levels of the indicated proteins in Caco-2 cells treated for 24 h. The expression of the investigated proteins in treated Caco-2 cells was calculated and normalized to the β-actin protein level in each treated sample, and finally plotted as ( B ) the mean protein fold change from negative control (0.1%DMSO) (dotted line) ± SEM. It can be clearly seen that EC19 and E23 caused significant downregulation of all proteins in comparison to the 0.1% DMSO control. * p < 0.05, ** p < 0.01 and *** p < 0.001 indicate a statistically significant difference. ns; non-significant.
Antibodies Against Mdr1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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snp abcb1 c 7586662 10  (Thermo Fisher)
95
Thermo Fisher snp abcb1 c 7586662 10
Genotypic and allelic frequencies among DMT2 patients ( n = 103).
Snp Abcb1 C 7586662 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p gp  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc p gp
Genotypic and allelic frequencies among DMT2 patients ( n = 103).
P Gp, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp abcb1 cf02622140 m1  (Thermo Fisher)
93
Thermo Fisher gene exp abcb1 cf02622140 m1
Genotypic and allelic frequencies among DMT2 patients ( n = 103).
Gene Exp Abcb1 Cf02622140 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pcmv3 abcb1  (Sino Biological)
92
Sino Biological pcmv3 abcb1
Genotypic and allelic frequencies among DMT2 patients ( n = 103).
Pcmv3 Abcb1, supplied by Sino Biological, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Western blotting analysis of ABCB1 ( MDR1 ), ABCC1 ( MRP1 ) and Hsp70 in Caco-2 cells. ( A ) Representative immunoblotting images demonstrate the effect of IC 50 dose of ATRA, EC19, and EC23 on the expression levels of the indicated proteins in Caco-2 cells treated for 24 h. The expression of the investigated proteins in treated Caco-2 cells was calculated and normalized to the β-actin protein level in each treated sample, and finally plotted as ( B ) the mean protein fold change from negative control (0.1%DMSO) (dotted line) ± SEM. It can be clearly seen that EC19 and E23 caused significant downregulation of all proteins in comparison to the 0.1% DMSO control. * p < 0.05, ** p < 0.01 and *** p < 0.001 indicate a statistically significant difference. ns; non-significant.

Journal: International Journal of Molecular Sciences

Article Title: Augmented Therapeutic Potential of EC-Synthetic Retinoids in Caco-2 Cancer Cells Using an In Vitro Approach

doi: 10.3390/ijms23169442

Figure Lengend Snippet: Western blotting analysis of ABCB1 ( MDR1 ), ABCC1 ( MRP1 ) and Hsp70 in Caco-2 cells. ( A ) Representative immunoblotting images demonstrate the effect of IC 50 dose of ATRA, EC19, and EC23 on the expression levels of the indicated proteins in Caco-2 cells treated for 24 h. The expression of the investigated proteins in treated Caco-2 cells was calculated and normalized to the β-actin protein level in each treated sample, and finally plotted as ( B ) the mean protein fold change from negative control (0.1%DMSO) (dotted line) ± SEM. It can be clearly seen that EC19 and E23 caused significant downregulation of all proteins in comparison to the 0.1% DMSO control. * p < 0.05, ** p < 0.01 and *** p < 0.001 indicate a statistically significant difference. ns; non-significant.

Article Snippet: The membranes were then blocked, washed and incubated with antibodies against MDR1 (1:1000, #12683; Cell Signaling Technology, Danvers, MA, USA), MRP1 (1: 1500, #72202, Cell Signaling Technology), Hsp70 (1:1000, #MA3-009, Thermo Scientific, Waltham, MA, USA) and β-actin (1:3000, #A5060, Sigma-Aldrich, St. Louis, MO, USA) for 16–17 h at 4 °C in a humidified chamber.

Techniques: Western Blot, Expressing, Negative Control, Comparison, Control

Genotypic and allelic frequencies among DMT2 patients ( n = 103).

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Genotypic and allelic frequencies among DMT2 patients ( n = 103).

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques:

Therapeutic efficacy by studying SNP and DMT2 patients’ genotype.

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Therapeutic efficacy by studying SNP and DMT2 patients’ genotype.

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques:

Metformin plasmatic concentrations among DMT2 patients grouped by SNP and genotype.

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Metformin plasmatic concentrations among DMT2 patients grouped by SNP and genotype.

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques:

Metformin plasmatic concentration boxplots (ng/mL), including medians, interquartile ranges, and outliers (filled circles). ( A ) rs1128503 ( ABCB1 ). ( B ) rs2032582 ( ABCB1 ). ( C ) rs1045642 ( ABCB1 ). Metformin to the left, metformin + glibenclamide to the right according to genotype. Only C/T of rs1128503 reported both extra-group (metformin + glibenclamide) (** p = 0.002) and intra-group (metformin) statistical difference (* p = 0.007).

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Metformin plasmatic concentration boxplots (ng/mL), including medians, interquartile ranges, and outliers (filled circles). ( A ) rs1128503 ( ABCB1 ). ( B ) rs2032582 ( ABCB1 ). ( C ) rs1045642 ( ABCB1 ). Metformin to the left, metformin + glibenclamide to the right according to genotype. Only C/T of rs1128503 reported both extra-group (metformin + glibenclamide) (** p = 0.002) and intra-group (metformin) statistical difference (* p = 0.007).

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques: Concentration Assay

Metformin concentration points (ng/ml) and metformin dosage (mg/Kg/day), including angular regression coefficient with p value and determination coefficient. ( A ) metformin monotherapy patients grouped by ABCB1 (rs1045642). ( B ) metformin+glibenclamide patients grouped by ABCB1 (rs1045642). C/T presents a positive correlation among metformin monotherapy (*: p = 0.017).

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Metformin concentration points (ng/ml) and metformin dosage (mg/Kg/day), including angular regression coefficient with p value and determination coefficient. ( A ) metformin monotherapy patients grouped by ABCB1 (rs1045642). ( B ) metformin+glibenclamide patients grouped by ABCB1 (rs1045642). C/T presents a positive correlation among metformin monotherapy (*: p = 0.017).

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques: Concentration Assay

Glycated hemoglobin (HbA1c) among DMT2 patients grouped by treatment and genotype.

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Glycated hemoglobin (HbA1c) among DMT2 patients grouped by treatment and genotype.

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques:

Logistic regression on genotypic models in OCT1 and ABCB1 across uncontrolled patients. ( n = 103).

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Logistic regression on genotypic models in OCT1 and ABCB1 across uncontrolled patients. ( n = 103).

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques:

Multiple logistic regression on HbA1c no-control using a dominant genotype model for SLC22A1 and ABCB1 ( n = 103).

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Multiple logistic regression on HbA1c no-control using a dominant genotype model for SLC22A1 and ABCB1 ( n = 103).

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques: Significance Assay

Daily metformin dose mg/kg/day according to treatment and genotype.

Journal: Pharmaceuticals

Article Title: Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients

doi: 10.3390/ph15070774

Figure Lengend Snippet: Daily metformin dose mg/kg/day according to treatment and genotype.

Article Snippet: Reactions were performed in a final reaction volume of 10 μL, with 30 ng genomic DNA template, 1X TaqMan ® Universal PCR Master mix system from Applied Biosystems, 1X each probe assessed ( CYP2C9*1 : C_160889442_10, CYP2C9*2 : rs1799853, C_25625805_10; CYP2C9*3 : rs1057910, C_27104892_10; CYP2C9*6: rs9332131, C_32287221_20; SLC22A1: rs12208357, C__30634096_10; SLC22A1: rs2282143, C__15877554_40; SLC22A1: rs594709, C___1898206_20; SLC22A1: rs622342, C____928527_30; SLC22A1: rs628031, C___8709275_60; SLC22A1: rs683369, C____928536_30; SLC22A1: rs72552763, C__34211613_10; SLC22A2: rs316019, C___3111809_20; SLC22A3: rs2076828, C___2763995_1_; SLC22A3: rs8187725, C__30633894_10; ABCB1: rs1045642, C___7586657_20; ABCB1: rs1128503, C___7586662_10; ABCB1: rs2032582, C_11711720D_40; ABCB1: rs2032582, C_11711720C_30; ABCB1: rs2032588, C__11711718_10), and water.

Techniques: