aav8 tbg cre hepatocyte specific Search Results


aav8 tbg cre  (Vector Biolabs)
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aav8-tbg-cre vectors #sl101528  (SignaGen)
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aav8-tbg-cre  (Addgene inc)
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aav-tbg-icre  (Vector Biolabs)
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aav8 particles expressing aav tbg pi cre rbg  (Addgene inc)
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aav8 tbg cre  (Addgene inc)
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Addgene inc aav8 tbg cre
Aav8 Tbg Cre, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav8-tbg-cre  (Obio Technology Corp Ltd)
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Obio Technology Corp Ltd aav8-tbg-cre
(A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose <t>AAV8-TBG-Cre</t> is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.
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vb1743 aav8 tbg cre vector biolabs  (Vector Biolabs)
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Vector Biolabs vb1743 aav8 tbg cre vector biolabs
(A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose <t>AAV8-TBG-Cre</t> is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.
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aav8-tbg-cre av-8-pv1091  (Addgene inc)
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Addgene inc aav8-tbg-cre av-8-pv1091
(A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose <t>AAV8-TBG-Cre</t> is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.
Aav8 Tbg Cre Av 8 Pv1091, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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yaav aav8-prox1  (Genechem)
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Genechem yaav aav8-prox1
(A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose <t>AAV8-TBG-Cre</t> is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.
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Image Search Results


(A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose AAV8-TBG-Cre is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.

Journal: bioRxiv

Article Title: Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cells

doi: 10.1101/2024.11.02.621695

Figure Lengend Snippet: (A) RNA velocity streamline plot depicting potential cell transitions. Streamline number and continuity reflect the predicted probability of cell fate transitions. (B) Heatmap of gene expression during hepatocyte transdifferentiation into imCho1. (C) Immunostaining of CK19, HNF4α, and SPP1 expression in liver sections. 3-week-old control or Sav1 −/− ;Wwc −/− livers are analyzed. WT livers display high HNF4α expression and no SPP1 expression in all hepatocytes (ROI #1 and ROI #2). In Sav1 −/− ;Wwc −/− livers, in addition to normal hepatocytes (ROI #1), a population of hepatocytes with low HNF4α and high SPP1 expression (ROI #2) emerges. Scale: 10 μm. ROI: region of interest. (D) Schematic diagram showing hepatocyte-specific Hippo pathway gene deletions and lineage tracing experiment. Low-dose AAV8-TBG-Cre is injected via tail vein into 4-week-old mice with genetic backgrounds of Ai9;Nf2 F/F ;Wwc F/F and Ai9;Sav1 F/F ;Wwc F/F . Liver samples were harvested and analyzed at 7 days (+7), 14 days (+14), 17 days (+17), or 21 days (+21) after injection. Hepatocytes with Cre expression are traced by tdTomato expression. (E) Immunostaining of SPP1, CK19, and tdTomato in liver sections. Livers from mice at different time points following AAV8-TBG-Cre injection are collected, sectioned, and subjected to immunostaining. For each genotype, the upper panels are merged signals from SPP1 (red), CK19 (green), and DAPI (blue); lower panels show tdTomato (white) and DAPI (blue) for the same field. ROI #0: Normal hepatocytes (no SPP1 expression, tdTomato positive); ROI #1: Cholangiocytes and cholangiocyte-derived cells (low SPP1 expression, high CK19 expression, tdTomato negative); ROI #2: Pre-imCho1 cells (SPP1 positive, tdTomato positive); ROI #3: imCho1 cells derived from hepatocytes (high SPP1 expression, low CK19 expression, tdTomato positive). Scale bar: 10 μm. (F) Schematic diagram showing hepatocyte reprogramming and stepwise transdifferentiation into imCho1. (G and H) Temporal analysis of the expression of Wwc1 -mNeongreen. Liver samples were obtained from WT mice and Wwc1 -mNeongreen knock-in mice on different postnatal days (1, 7, 21,35). Protein expression (G) and immunostaining with TSA (H) are shown.

Article Snippet: For hepatocyte-specific gene deletion using AAV8-TBG-cre (Obio Technology, #H5721), 1-month-old mice were injected with adeno-associated virus (1×10 viral genomes for each mouse) via the lateral tail vein.

Techniques: Expressing, Immunostaining, Control, Injection, Derivative Assay, Knock-In