aav8 Search Results


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PackGene Biotech lnc aav8 vector
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs adeno associated virus serotype 8 aav8
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vigene Biosciences vigene n a aav5 u6
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Addgene inc aav8 hsyn
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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PackGene Biotech lnc scaav8 cmv egfp
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8 hsyn hm4d gi mcherry
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8 tbg null
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8 adeno associated virus serotype 8 expressing mouse ism1
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8 tbg icre
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Shanghai Genechem Ltd virus strains aav8 gfp shanghai genechem co
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Vector Biolabs aav8 cag egfp
In vivo mouse PCSK9 gene editing using single <t>AAV8</t> - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Image Search Results


In vivo mouse PCSK9 gene editing using single AAV8 - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Journal: Nucleic Acids Research

Article Title: Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

doi: 10.1093/nar/gkae800

Figure Lengend Snippet: In vivo mouse PCSK9 gene editing using single AAV8 - packaged SflSdd-CBE (nSaCas9) 2.0. ( A ) Theoretical packaging of SflSdd-CBE (nSaCas9) 2.0 into a single AAV8. The top, shows the architectures of AncBE4max (nSaCas9), BE4-gam (nSaCas9), and Sdd-CBE (nSaCas9) 2.0, with AncBE4max (nSaCas9) and BE4-gam (nSaCas9) in gray, indicating their size exceeds the single AAV packaging limit. The bottom presents a schematic representation of AAV8-SflSdd-CBE (nSaCas9) 2.0. ( B ) Experimental timeline for tail-vein injections and subsequent analyses using AAV8-SflSdd-CBE (nSaCas9) 2.0. ( C ) Editing efficiencies of SflSdd-CBE (nSaCas9) 2.0 at the Pcsk9 site in liver tissue post-injection of AAV8 at 5 × 10 11 total genome copies. (D-E) Four-week post-injection quantification of total serum cholesterol levels ( D ), serum ALB levels ( E ), serum ALT levels ( F ) and serum AST levels ( G ) (PBS, n = 5; AAV8- PCSK9 , n = 4). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Article Snippet: The AAV8 vector was also made by Packgene Biotech Company.

Techniques: In Vivo, Injection