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Image Search Results
Journal: bioRxiv
Article Title: HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity
doi: 10.1101/2022.06.13.495862
Figure Lengend Snippet: A Volcano plots showing upregulated and downregulated ncRNAs in KYSE450/DDP and YES2/DDP cells compared to their parental cells. B RT–qPCR detection of HCP5 expression in the parental and DDP-resistant cell models. The data are presented as the means ± s.d.; two-tailed t test, *** P < 0.001; n = 3. C RT–qPCR detection of HCP5 expression in KYSE30 and KYSE450 cells treated with DDP for 0, 6, 12, and 24 h. The data are presented as the means ± s.d.; two-tailed t test, *** P < 0.001, ** P < 0.01, * P < 0.05; n = 3. D Overall survival of ESCC patients with low and high HCP5 expression levels (divided by the mean expression value). Kaplan–Meier survival plots are shown. E Statistical analysis of HCP5 expression in 168 paired ESCC tissues and adjacent normal tissues. Box plot representation: from top to bottom—maximum, 75th percentile; median, 25th percentile; and minimum values; two-tailed t test. F Statistical analysis of HCP5 expression in 53 paired ESCC tissues and adjacent normal tissues in the GEO database. Box plot representation: from top to bottom—maximum, 75th percentile; median, 25th percentile; and minimum values; two-tailed t test. G-J Tumor volumes and representative images (G and I) and tumor weights (H and J) of the xenografts derived from the indicated cells. The data are presented as the means ± s.e.m.; two-tailed t test, *** P < 0.001, ** P < 0.01; n = 7. K-M Tumor weights in the three PDX models from ESCC patients treated with AAV-shCtrl or AAV-shHCP5. The data are presented as the means ± s.e.m.; two-tailed t test, *** P < 0.001; n = 8.
Article Snippet:
Techniques: Quantitative RT-PCR, Expressing, Two Tailed Test, Derivative Assay