a2780 Search Results


human ovarian carcinoma a2780 cells  (CancerTools Org)
99
CancerTools Org human ovarian carcinoma a2780 cells
Human Ovarian Carcinoma A2780 Cells, supplied by CancerTools Org, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human ovarian carcinoma a2780 cells - by Bioz Stars, 2026-03
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a2780 cells  (CLS Cell Lines Service GmbH)
93
CLS Cell Lines Service GmbH a2780 cells
A2780 Cells, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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ovarian cancer cell lines a2780  (Procell Inc)
90
Procell Inc ovarian cancer cell lines a2780
Ovarian Cancer Cell Lines A2780, supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
ovarian cancer cell lines a2780 - by Bioz Stars, 2026-03
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a2780/cddp cells  (Pasteur Institute)
90
Pasteur Institute a2780/cddp cells
A2780/Cddp Cells, supplied by Pasteur Institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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a2780 human ovarian cancer cell line  (European Collection of Authenticated Cell Cultures)
90
European Collection of Authenticated Cell Cultures a2780 human ovarian cancer cell line
A2780 Human Ovarian Cancer Cell Line, supplied by European Collection of Authenticated Cell Cultures, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
a2780 human ovarian cancer cell line - by Bioz Stars, 2026-03
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a2780  (Charles River Laboratories)
90
Charles River Laboratories a2780
A2780, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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a2780/ddp  (Shanghai Genechem Ltd)
90
Shanghai Genechem Ltd a2780/ddp
A2780/Ddp, supplied by Shanghai Genechem Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a2780  (Dainippon Sumitomo)
90
Dainippon Sumitomo a2780
A2780, supplied by Dainippon Sumitomo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human ovarian cancer cell lines a2780  (Genechem)
90
Genechem human ovarian cancer cell lines a2780
Human Ovarian Cancer Cell Lines A2780, supplied by Genechem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human oc cell lines a2780  (iCell Bioscience Inc)
90
iCell Bioscience Inc human oc cell lines a2780
Human Oc Cell Lines A2780, supplied by iCell Bioscience Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a2780 cell line mixed 1:1 matrigel  (GemPharmatech Co Ltd)
90
GemPharmatech Co Ltd a2780 cell line mixed 1:1 matrigel
A2780 Cell Line Mixed 1:1 Matrigel, supplied by GemPharmatech Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a2780  (China Center for Type Culture Collection)
90
China Center for Type Culture Collection a2780
Metformin inhibits the proliferation of ovarian cancer cells. EdU assays demonstrate that metformin reduces proliferation of (A) SKOV3, (B) <t>A2780</t> and (C) ES2 cells. Representative fluorescence microscopy images of EdU incorporation and Hoechst 33342 staining of nuclei (magnification, ×100). The proliferation rates of SKOV3, A2780, and ES2 cells were calculated. Data are presented as the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; EdU, 5-ethynyl-20-deoxyuridine; NC, negative control.
A2780, supplied by China Center for Type Culture Collection, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Metformin inhibits the proliferation of ovarian cancer cells. EdU assays demonstrate that metformin reduces proliferation of (A) SKOV3, (B) A2780 and (C) ES2 cells. Representative fluorescence microscopy images of EdU incorporation and Hoechst 33342 staining of nuclei (magnification, ×100). The proliferation rates of SKOV3, A2780, and ES2 cells were calculated. Data are presented as the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; EdU, 5-ethynyl-20-deoxyuridine; NC, negative control.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin inhibits the proliferation of ovarian cancer cells. EdU assays demonstrate that metformin reduces proliferation of (A) SKOV3, (B) A2780 and (C) ES2 cells. Representative fluorescence microscopy images of EdU incorporation and Hoechst 33342 staining of nuclei (magnification, ×100). The proliferation rates of SKOV3, A2780, and ES2 cells were calculated. Data are presented as the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; EdU, 5-ethynyl-20-deoxyuridine; NC, negative control.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Fluorescence, Microscopy, Staining, Standard Deviation, Negative Control

Metformin promotes the apoptosis of ovarian cancer cells. Percentage of apoptotic (A) SKOV3, (B) A2780 and (C) ES2 cells were detected by flow cytometry analysis using Annexin V-fluorescein isothiocyanate/PI staining. Apoptotic cells includes Annexin V(-)/PI(+), Annexin V(+)/PI(−) and Annexin V(+)/PI(+) cells. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01. PI, propidium iodide; Met, metformin; Glu, glucose; NC, negative control.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin promotes the apoptosis of ovarian cancer cells. Percentage of apoptotic (A) SKOV3, (B) A2780 and (C) ES2 cells were detected by flow cytometry analysis using Annexin V-fluorescein isothiocyanate/PI staining. Apoptotic cells includes Annexin V(-)/PI(+), Annexin V(+)/PI(−) and Annexin V(+)/PI(+) cells. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01. PI, propidium iodide; Met, metformin; Glu, glucose; NC, negative control.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Flow Cytometry, Staining, Standard Deviation, Negative Control

Metformin inhibits migration of ovarian cancer cells. Migration of (A) SKOV3, (B) A2780 and (C) ES2 cells were measured by scratch wound healing assay. Representative bright-field images (magnification, ×100) and quantification of recovered distance at 24 h after 10 mM metformin treatment. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; NC, negative control.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin inhibits migration of ovarian cancer cells. Migration of (A) SKOV3, (B) A2780 and (C) ES2 cells were measured by scratch wound healing assay. Representative bright-field images (magnification, ×100) and quantification of recovered distance at 24 h after 10 mM metformin treatment. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; NC, negative control.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Migration, Wound Healing Assay, Standard Deviation, Negative Control

Metformin inhibits migration of ovarian cancer cells. Migration of (A) SKOV3, (B) A2780 and (C) ES2 cells were measured by Transwell migration assay. Representative bright-field images of the cell migration (magnification, ×100) and quantification of migrated cells at 24 h after 10 mM metformin treatment are shown. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; NC, negative control.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin inhibits migration of ovarian cancer cells. Migration of (A) SKOV3, (B) A2780 and (C) ES2 cells were measured by Transwell migration assay. Representative bright-field images of the cell migration (magnification, ×100) and quantification of migrated cells at 24 h after 10 mM metformin treatment are shown. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; NC, negative control.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Migration, Transwell Migration Assay, Standard Deviation, Negative Control

Metformin decreases H3K27me3 and expression of polycomb repressor complex 2 in ovarian cancer cells. The protein expression of (A) H3K27me3 and (B) EZH2, SUZ12 and EED in A2780, SKOV3 and ES2 cells were assayed by western blot analysis. Met, metformin; Glu, glucose; H3K27me3, histone H3 lysine 27 trimethylated; H3, histone H3; EZH2, histone-lysine N-methyltransferase EZH2; SUZ12, polycomb protein SUZ12; EED, polycomb protein EED.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin decreases H3K27me3 and expression of polycomb repressor complex 2 in ovarian cancer cells. The protein expression of (A) H3K27me3 and (B) EZH2, SUZ12 and EED in A2780, SKOV3 and ES2 cells were assayed by western blot analysis. Met, metformin; Glu, glucose; H3K27me3, histone H3 lysine 27 trimethylated; H3, histone H3; EZH2, histone-lysine N-methyltransferase EZH2; SUZ12, polycomb protein SUZ12; EED, polycomb protein EED.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Expressing, Western Blot

Metformin decreases PRC2 of ovarian cancer cells. mRNA expression of EZH2, SUZ12 and EED in (A) SKOV3, (B) A2780 and (C) ES2 cells determined by reverse transcription-quantitative polymerase chain reaction analysis. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; EZH2, histone-lysine N-methyltransferase EZH2; SUZ12, polycomb protein SUZ12; EED, polycomb protein EED.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin decreases PRC2 of ovarian cancer cells. mRNA expression of EZH2, SUZ12 and EED in (A) SKOV3, (B) A2780 and (C) ES2 cells determined by reverse transcription-quantitative polymerase chain reaction analysis. Data are presented the mean ± standard deviation. * P<0.05; ** P<0.01; *** P<0.001. Met, metformin; Glu, glucose; EZH2, histone-lysine N-methyltransferase EZH2; SUZ12, polycomb protein SUZ12; EED, polycomb protein EED.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Expressing, Reverse Transcription, Real-time Polymerase Chain Reaction, Standard Deviation

Metformin inhibits H3K27me3 through the AMPK pathway. (A) Metformin activates AMPK of ovarian cancer cells in normoglycemic condition. (B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition. (C) Compound C inhibits the effect of metformin on PRC2 and H3K27me3 when ovarian cancer cells were cultured in normoglycemic condition. The protein expression of p-AMPKα, AMPKα, H3K27me3, EZH2, SUZ12 and EED in A2780, SKOV3 and ES2 cells were assayed by western blot analysis. The expression was normalized to β-actin. Met, metformin; Glu, glucose; p-AMPKα, phospho-AMPKα; AMPKα, AMP-activated protein kinase; 2-DG, 2-deoxy-D-glucose; EZH2, histone-lysine N-methyltransferase EZH2;SUZ12, polycomb protein SUZ12; EED, polycomb protein EED; 2-DG, dorsomorphin 2HCl; H3K27me3, histone H3 lysine 27 trimethylation.

Journal: International Journal of Oncology

Article Title: Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

doi: 10.3892/ijo.2018.4343

Figure Lengend Snippet: Metformin inhibits H3K27me3 through the AMPK pathway. (A) Metformin activates AMPK of ovarian cancer cells in normoglycemic condition. (B) 2-DG activates AMPK and suppresses H3K27me3, PRC2 of ovarian cancer cells in normoglycemic condition. (C) Compound C inhibits the effect of metformin on PRC2 and H3K27me3 when ovarian cancer cells were cultured in normoglycemic condition. The protein expression of p-AMPKα, AMPKα, H3K27me3, EZH2, SUZ12 and EED in A2780, SKOV3 and ES2 cells were assayed by western blot analysis. The expression was normalized to β-actin. Met, metformin; Glu, glucose; p-AMPKα, phospho-AMPKα; AMPKα, AMP-activated protein kinase; 2-DG, 2-deoxy-D-glucose; EZH2, histone-lysine N-methyltransferase EZH2;SUZ12, polycomb protein SUZ12; EED, polycomb protein EED; 2-DG, dorsomorphin 2HCl; H3K27me3, histone H3 lysine 27 trimethylation.

Article Snippet: Human epithelial ovarian cancer cell lines SKOV3 (ovarian adenocarcinoma), ES2 (ovarian clear cell carcinoma), and A2780 (ovarian carcinoma) were purchased from China Center for Type Culture Collection (Wuhan University, Wuhan, China) and were cultured in Dulbecco's modified Eagle's medium (DMEM) (HyClone; GE Healthcare Life Sciences, Logan, UT, USA) containing 25 mM glucose (mimicking hyperglycemia) or 5.5 mM glucose (mimicking normoglycemia) supplemented with 10% fetal bovine serum (v/v; Hangzhou Sijiqing Biological Engineering Materials Co., Ltd., Hangzhou, China) at 37°C in 95% air and 5% CO 2 .

Techniques: Cell Culture, Expressing, Western Blot