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Fig. 3 MRAS and HEG1 are highly expressed in <t>osimertinib-resistant</t> cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)
Osimertinib, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 3 MRAS and HEG1 are highly expressed in <t>osimertinib-resistant</t> cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)
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Fig. 3 MRAS and HEG1 are highly expressed in <t>osimertinib-resistant</t> cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)
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Fig. 3 MRAS and HEG1 are highly expressed in <t>osimertinib-resistant</t> cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)
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Fig. 3 MRAS and HEG1 are highly expressed in osimertinib-resistant cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)

Journal: Discover oncology

Article Title: Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD.

doi: 10.1007/s12672-024-01552-6

Figure Lengend Snippet: Fig. 3 MRAS and HEG1 are highly expressed in osimertinib-resistant cells and tissues. A The Venn plot of DEGs from the merged dataset and six datasets. B The heatmap of MRAS and HEG1 in osimertinib-sensitive and resistant LUAD cells from six GEO datasets. C Bare mean of counts of MRAS and HEG1 from the online RNA-seq data [9]. D IHC analysis of MRAS in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). E IHC analysis of HEG1 in tumor biopsies from LUAD patients (left panel). The DAB positive signals were analyzed by the Halo data analysis system (right panel). F-G The Kaplan–Meier plots of the survival analysis of LUAD patient data from the GSE14814 dataset (N = 265)

Article Snippet: Osimertinib (Cat. S7297) and AZD1332 (Cat. A-495) were purchased from Selleck (USA) and Alomone Labs Vol:. (1234567890) (Israel), respectively.

Techniques: RNA Sequencing