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  • 86
    Magnex Scientific Limited 5 t 130
    5 T 130, supplied by Magnex Scientific Limited, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/5 t 130/product/Magnex Scientific Limited
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    5 t 130 - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Biacore imb t130
    Structure of <t>IMB-T130</t> (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).
    Imb T130, supplied by Biacore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/imb t130/product/Biacore
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    imb t130 - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    J&K Scientific compound imb t130
    Structure of <t>IMB-T130</t> (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).
    Compound Imb T130, supplied by J&K Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound imb t130/product/J&K Scientific
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    compound imb t130 - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Waters Corporation imb t130 plasma concentration
    Structure of <t>IMB-T130</t> (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).
    Imb T130 Plasma Concentration, supplied by Waters Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/imb t130 plasma concentration/product/Waters Corporation
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    imb t130 plasma concentration - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    86
    Verlag GmbH 352 seiten n i t 130 abbildungen und 25 tabellen
    Structure of <t>IMB-T130</t> (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).
    352 Seiten N I T 130 Abbildungen Und 25 Tabellen, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/352 seiten n i t 130 abbildungen und 25 tabellen/product/Verlag GmbH
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    352 seiten n i t 130 abbildungen und 25 tabellen - by Bioz Stars, 2023-01
    86/100 stars
      Buy from Supplier

    Image Search Results


    Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques:

    Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques: Inhibition, Incubation, Activity Assay, Concentration Assay

    SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques: Purification

    Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques:

    Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques: Concentration Assay

    Antibacterial activity of  IMB-T130  against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Antibacterial activity of IMB-T130 against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques: Activity Assay, Plasmid Preparation

    Intracellular anti-TB activity of  IMB-T130.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Intracellular anti-TB activity of IMB-T130.

    Article Snippet: Next, the chip was exposed to different concentrations of IMB-T130, and the response units for five different concentrations (1.875–30 μM) of IMB-T130 were measured by SPR (BIAcore X100 instrument, GE Healthcare).

    Techniques: Activity Assay

    Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques:

    Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques: Inhibition, Incubation, Activity Assay, Concentration Assay

    SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques: Purification

    Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques:

    Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques: Concentration Assay

    Antibacterial activity of  IMB-T130  against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Antibacterial activity of IMB-T130 against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques: Activity Assay, Plasmid Preparation

    Intracellular anti-TB activity of  IMB-T130.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Intracellular anti-TB activity of IMB-T130.

    Article Snippet: Compound IMB-T130 was purchased from J&K Chemical (China; synthesized by Enamine Ltd., Ukraine).

    Techniques: Activity Assay

    Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Structure of IMB-T130 (5-chloro-N-[4-(pyridin-2-yl)-1, 3-thiazol-2-yl] thiophene-2-carboxamide).

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques:

    Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Inhibition of DHQS by IMB-T130. DHQS (1 μg/mL) was incubated with 0.15–20 μg/mL of IMB-T130 at room temperature for 30 min and the catalytic activity was determined (see Methods section). The IC 50 value is plotted as the inhibition ratio of the OD 630 over the compound concentration (log plot) that fits a variable-slope dose-response equation. The experiment was repeated three times.

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques: Inhibition, Incubation, Activity Assay, Concentration Assay

    SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: SPR results for the interaction between DHQS and IMB-T130. A sensor chip coated with purified protein was exposed to 1.875–30 μM of IMB-T130. The change in response units is shown.

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques: Purification

    Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Molecular docking for DHQS and IMB-T130. ( a ) Overview of the active pocket of DHQS bound to IMB-T130. IMB-T130 is represented by a stick model (grey, carbon atoms; blue, nitrogen atoms; red, oxygen atoms; yellow, sulfur atoms; green, chlorine atoms). Red sticks represent the amino acid residues interacting with IMB-T130. ( b ) A carbonyl oxygen atom forms a conventional hydrogen bond with Asn154 and Lys323 (green line). A carbon-hydrogen bond formed between the carbonyl group of Asn246 and pyridine (grey line). Thiazole and pyridine formed different hydrophobic interactions with Lys144, Asn246, and His249 (purple and orange lines).

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques:

    Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Mean blood concentration profiles of IMB-T130 following oral (p.o) and iv doses of 20 and 5 mg/kg in in male Sprague Dawley rats. Pharmacokinetic parameters were determined after the administration of the oral and iv dose to rats. T max , time to reach C max ; C max , maximum plasma concentration; t (1/2) , half-life; AUC, area under the concentration curve; V ss , volume of distribution at steady state.

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques: Concentration Assay

    Antibacterial activity of  IMB-T130  against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Antibacterial activity of IMB-T130 against the M. smegmatis strains with a vector control or overexpressing plasmid for Mt DHQS and Mt L12 genes.

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques: Activity Assay, Plasmid Preparation

    Intracellular anti-TB activity of  IMB-T130.

    Journal: Scientific Reports

    Article Title: IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

    doi: 10.1038/s41598-018-35701-z

    Figure Lengend Snippet: Intracellular anti-TB activity of IMB-T130.

    Article Snippet: The IMB-T130 plasma concentration was determined by liquid chromatography-mass spectrometry using an ACQUITY UPLC BEH C18 column (Waters; 1.7 µm, 2.1 × 50 mm) .

    Techniques: Activity Assay