Journal: Journal of Translational Medicine
Article Title: microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis
Figure Lengend Snippet: Loss of STAT3 attenuates myocardial injury in mice with sepsis and reverses the effect of miR-193-3p inhibition on septic mice. A Western blot detected STAT3 protein expression. B – G Echocardiographic parameters and hemodynamic indexes of mice; H – J ELISA detected cTnI, BNP and HMGB1 in the serum; K – M ELISA detected LDH, CK and CK-MB expression levels; N – P ELISA detected TNF-α, IL-6 and IL-1β levels; n = 15; * P
Article Snippet: The contents of brain natriuretic peptide (BNP), cardiac troponinI (cTnI), HMGB1, lactic dehydrogenase (LDH), creatine kinase (CK), creatine kinase isozyme (CK-MB), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) were measured by enzyme-linked immunosorbent assay (ELISA).
Techniques: Mouse Assay, Inhibition, Western Blot, Expressing, Enzyme-linked Immunosorbent Assay