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R&D Systems
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Novus Biologicals
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Image Search Results
Journal: Frontiers in Immunology
Article Title: ATF3 Stimulates IL-17A by Regulating Intracellular Ca 2+ /ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection
doi: 10.3389/fimmu.2018.01954
Figure Lengend Snippet: ATF3 suppresses ROS generation and iNOS expression. (A) Fold change in ROS levels at 0, 2, 4, and 6 hpi compared to that in non-infected WT cells. (B) iNOS expression and (C) IHC (anti-iNOS) at 0 and 6 hpi ( n = 4). * P < 0.05, ** P < 0.01, two-way analysis of variance.
Article Snippet: The membranes were blocked with skim milk for 2 h, and then probed overnight with anti-GBP5 (gtx31537, Gentex, Zeeland, MI, USA),
Techniques: Expressing, Infection
Journal: Frontiers in Immunology
Article Title: ATF3 Stimulates IL-17A by Regulating Intracellular Ca 2+ /ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection
doi: 10.3389/fimmu.2018.01954
Figure Lengend Snippet: ATF3 plays an important role in IL-17A production in response to S. pneumoniae infection. Lung macrophages rapidly phagocytose invading S. pneumoniae during infection, resulting in ROS production, ER stress, and ATF3 activation. ATF3 then inhibits ROS-induced iNOS expression to promote NLRP3 inflammasome and GBP5 activation, triggering IL-1β secretion and the subsequent activation of γδ T cells in the lung .
Article Snippet: The membranes were blocked with skim milk for 2 h, and then probed overnight with anti-GBP5 (gtx31537, Gentex, Zeeland, MI, USA),
Techniques: Infection, Activation Assay, Expressing