HY-R00445 Search Results


mir  (MedChemExpress)
94
MedChemExpress mir
<t>miR-21-5p</t> <t>is</t> <t>the</t> key mediator of sEVs Hypo-5% in recovering cellular function of HG-HUVECs and HG-HDFs. (A) Representative EdU images showing the proliferation of HG-HUVECs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (B) Quantification of (A) ( n = 3 per group). (C) Scratch wound-healing assay of HG-HUVECs in different groups. Scale bar = 100 μm. (D) Quantification analysis of (C) ( n = 4 per group). (E) Matrigel tube-formation assay of HG-HUVECs after different treatments. Scale bar = 100 μm. (F) Quantification analysis of segments in (E) ( n = 3 per group). (G) Representative EdU images showing the proliferation of HG-HDFs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (H) Quantification analysis of (G) ( n = 3 per group). (I) Scratch wound-healing assay of HG-HDFs. Scale bar = 100 μm. (J) Quantification analysis of (I) ( n = 3 per group). (K) Transwell migration assay of HG-HDFs after different treatments. Scale bar = 100 μm. (L) Quantification analysis of (K) ( n = 4 per group). ns, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
Mir, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/HY-R00445/hsa-miR-21-5p+mimic/pmc13150076-295-29-34
Average 94 stars, based on 1 article reviews
mir - by Bioz Stars, 2026-11
94/100 stars
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hsa-mir-214-3p agomir  (MedChemExpress)
N/A
hsa-miR-214-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are
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hsa-mir-214-3p mimic  (MedChemExpress)
N/A
hsa-miR-214-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
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Image Search Results


miR-21-5p is the key mediator of sEVs Hypo-5% in recovering cellular function of HG-HUVECs and HG-HDFs. (A) Representative EdU images showing the proliferation of HG-HUVECs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (B) Quantification of (A) ( n = 3 per group). (C) Scratch wound-healing assay of HG-HUVECs in different groups. Scale bar = 100 μm. (D) Quantification analysis of (C) ( n = 4 per group). (E) Matrigel tube-formation assay of HG-HUVECs after different treatments. Scale bar = 100 μm. (F) Quantification analysis of segments in (E) ( n = 3 per group). (G) Representative EdU images showing the proliferation of HG-HDFs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (H) Quantification analysis of (G) ( n = 3 per group). (I) Scratch wound-healing assay of HG-HDFs. Scale bar = 100 μm. (J) Quantification analysis of (I) ( n = 3 per group). (K) Transwell migration assay of HG-HDFs after different treatments. Scale bar = 100 μm. (L) Quantification analysis of (K) ( n = 4 per group). ns, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Journal: Research

Article Title: Hypoxia-Challenged sEVs-Engineered Nanofiber Scaffolds Accelerate Diabetic Wound Healing via Reversing Cellular Dysfunction of Skin Repair Cells

doi: 10.34133/research.1248

Figure Lengend Snippet: miR-21-5p is the key mediator of sEVs Hypo-5% in recovering cellular function of HG-HUVECs and HG-HDFs. (A) Representative EdU images showing the proliferation of HG-HUVECs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (B) Quantification of (A) ( n = 3 per group). (C) Scratch wound-healing assay of HG-HUVECs in different groups. Scale bar = 100 μm. (D) Quantification analysis of (C) ( n = 4 per group). (E) Matrigel tube-formation assay of HG-HUVECs after different treatments. Scale bar = 100 μm. (F) Quantification analysis of segments in (E) ( n = 3 per group). (G) Representative EdU images showing the proliferation of HG-HDFs treated with NC mimic, sEVs Hypo-5% + inhibitor NC , sEVs Hypo-5% + inhibitor miR-21-5p , or miR-21-5p mimic. Scale bar = 100 μm. (H) Quantification analysis of (G) ( n = 3 per group). (I) Scratch wound-healing assay of HG-HDFs. Scale bar = 100 μm. (J) Quantification analysis of (I) ( n = 3 per group). (K) Transwell migration assay of HG-HDFs after different treatments. Scale bar = 100 μm. (L) Quantification analysis of (K) ( n = 4 per group). ns, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Article Snippet: HG-HUVECs and HG-HDFs were treated with NC mimic (HY- R04602 , MCE, USA), sEVs Hypo-5% + inhibitor NC (HY-RI04602, MCE, USA), sEVs Hypo-5% + inhibitor miR-21-5p (HY-RI00449, MCE), or miR-21-5p mimic (HY- R00449 , MCE).

Techniques: Cell Function Assay, Wound Healing Assay, Tube Formation Assay, Transwell Migration Assay