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mavoglurant  (MedChemExpress)
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MedChemExpress mavoglurant
Effect of intraperitoneal <t>mavoglurant</t> administration on intravenous cocaine self-administration under ShA conditions. (A) Timeline of the experiment. Acquisition data are not shown. (B) Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the ShA group. (C) Number of cocaine infusions in male and female rats following intraperitoneal mavoglurant administration. (D) Locomotion in male and female rats following intraperitoneal mavoglurant administration. The data are expressed as the mean ± SEM. n = 7 males (blue symbols), 6 females (red symbols); + p < 0.05, +++ p < 0.001, difference from session 1, regardless of sex; ## p < 0.01, difference between males and females. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1
Mavoglurant, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/HY-152575/Mavoglurant/pmc11513716-50-3-7
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mavoglurant - by Bioz Stars, 2026-09
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Effect of intraperitoneal mavoglurant administration on intravenous cocaine self-administration under ShA conditions. (A) Timeline of the experiment. Acquisition data are not shown. (B) Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the ShA group. (C) Number of cocaine infusions in male and female rats following intraperitoneal mavoglurant administration. (D) Locomotion in male and female rats following intraperitoneal mavoglurant administration. The data are expressed as the mean ± SEM. n = 7 males (blue symbols), 6 females (red symbols); + p < 0.05, +++ p < 0.001, difference from session 1, regardless of sex; ## p < 0.01, difference between males and females. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Journal: Psychopharmacology

Article Title: The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats

doi: 10.1007/s00213-024-06634-5

Figure Lengend Snippet: Effect of intraperitoneal mavoglurant administration on intravenous cocaine self-administration under ShA conditions. (A) Timeline of the experiment. Acquisition data are not shown. (B) Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the ShA group. (C) Number of cocaine infusions in male and female rats following intraperitoneal mavoglurant administration. (D) Locomotion in male and female rats following intraperitoneal mavoglurant administration. The data are expressed as the mean ± SEM. n = 7 males (blue symbols), 6 females (red symbols); + p < 0.05, +++ p < 0.001, difference from session 1, regardless of sex; ## p < 0.01, difference between males and females. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Article Snippet: For oral administration, mavoglurant was purchased from MedChemExpress (catalog no. HY-15,257, Monmouth Junction, NJ, USA) and suspended in 0.5% methylcellulose in water and administered at doses of 0, 1, 3, 10 mg/kg 60 min before behavioral testing.

Techniques:

Effect of intraperitoneal mavoglurant administration on intravenous cocaine self-administration under LgA conditions. A. Timeline of the experiment. Acquisition data are not shown. B, C. Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the LgA group in the ( B ) first hour and ( C ) entire 6 h sessions. D, E. Number of cocaine infusions in the ( D ) first hour and ( E ) entire 6 h sessions in male and female rats following intraperitoneal mavoglurant administration. F, G. Locomotion in the ( F) first hour and ( G ) 6 h in male and female rats following intraperitoneal mavoglurant administration. The data are expressed as the mean ± SEM. n = 6 males (blue symbols), 7 females (red symbols). + p < 0.05, ++ p < 0.01, +++ p < 0.001, difference from session 1, regardless of sex; ** p < 0.01, difference from 0 mg/kg. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Journal: Psychopharmacology

Article Title: The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats

doi: 10.1007/s00213-024-06634-5

Figure Lengend Snippet: Effect of intraperitoneal mavoglurant administration on intravenous cocaine self-administration under LgA conditions. A. Timeline of the experiment. Acquisition data are not shown. B, C. Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the LgA group in the ( B ) first hour and ( C ) entire 6 h sessions. D, E. Number of cocaine infusions in the ( D ) first hour and ( E ) entire 6 h sessions in male and female rats following intraperitoneal mavoglurant administration. F, G. Locomotion in the ( F) first hour and ( G ) 6 h in male and female rats following intraperitoneal mavoglurant administration. The data are expressed as the mean ± SEM. n = 6 males (blue symbols), 7 females (red symbols). + p < 0.05, ++ p < 0.01, +++ p < 0.001, difference from session 1, regardless of sex; ** p < 0.01, difference from 0 mg/kg. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Article Snippet: For oral administration, mavoglurant was purchased from MedChemExpress (catalog no. HY-15,257, Monmouth Junction, NJ, USA) and suspended in 0.5% methylcellulose in water and administered at doses of 0, 1, 3, 10 mg/kg 60 min before behavioral testing.

Techniques:

Effect of 10 mg/kg mavoglurant vs. vehicle on intravenous cocaine self-administration over time under LgA conditions

Journal: Psychopharmacology

Article Title: The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats

doi: 10.1007/s00213-024-06634-5

Figure Lengend Snippet: Effect of 10 mg/kg mavoglurant vs. vehicle on intravenous cocaine self-administration over time under LgA conditions

Article Snippet: For oral administration, mavoglurant was purchased from MedChemExpress (catalog no. HY-15,257, Monmouth Junction, NJ, USA) and suspended in 0.5% methylcellulose in water and administered at doses of 0, 1, 3, 10 mg/kg 60 min before behavioral testing.

Techniques:

Effect of oral mavoglurant administration on intravenous cocaine self-administration under ShA conditions in rats. (A) Timeline of the experiment. Acquisition data are not shown. (B) Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the ShA group. (C) Number of cocaine infusions in male and female rats following oral mavoglurant administration. (D) Locomotion in male and female rats following oral mavoglurant administration. The data are expressed as the mean ± SEM. n = 7 males (blue symbols), 5 females (red symbols). + p < 0.05, ++ p < 0.01, difference from session 1, regardless of sex. * p < 0.05, difference from 0 mg/kg. IV, Intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Journal: Psychopharmacology

Article Title: The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats

doi: 10.1007/s00213-024-06634-5

Figure Lengend Snippet: Effect of oral mavoglurant administration on intravenous cocaine self-administration under ShA conditions in rats. (A) Timeline of the experiment. Acquisition data are not shown. (B) Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the ShA group. (C) Number of cocaine infusions in male and female rats following oral mavoglurant administration. (D) Locomotion in male and female rats following oral mavoglurant administration. The data are expressed as the mean ± SEM. n = 7 males (blue symbols), 5 females (red symbols). + p < 0.05, ++ p < 0.01, difference from session 1, regardless of sex. * p < 0.05, difference from 0 mg/kg. IV, Intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Article Snippet: For oral administration, mavoglurant was purchased from MedChemExpress (catalog no. HY-15,257, Monmouth Junction, NJ, USA) and suspended in 0.5% methylcellulose in water and administered at doses of 0, 1, 3, 10 mg/kg 60 min before behavioral testing.

Techniques:

Effect of oral mavoglurant administration on intravenous cocaine self-administration under LgA conditions in rats. A. Timeline of the experiment. Acquisition data are not shown. B, C. Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the LgA group in the ( B ) first hour and ( C ) entire 6 h sessions. D, E. Number of cocaine infusions in the ( D ) first hour and ( E ) entire 6 h sessions in male and female rats following oral mavoglurant administration. F, G. Locomotion in the ( F) first hour and ( G ) 6 h session in male and female rats following oral mavoglurant administration. The data are expressed as the mean ± SEM. n = 9 males (blue symbols), 7 females (red symbols). + p < 0.05, ++ p < 0.01, +++ p < 0.001, difference from session 1, regardless of sex; * p < 0.05, ** p < 0.01, difference from 0 mg/kg. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Journal: Psychopharmacology

Article Title: The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats

doi: 10.1007/s00213-024-06634-5

Figure Lengend Snippet: Effect of oral mavoglurant administration on intravenous cocaine self-administration under LgA conditions in rats. A. Timeline of the experiment. Acquisition data are not shown. B, C. Number of cocaine infusions (750 µg/kg/0.1 ml) before mavoglurant testing in male and female rats in the LgA group in the ( B ) first hour and ( C ) entire 6 h sessions. D, E. Number of cocaine infusions in the ( D ) first hour and ( E ) entire 6 h sessions in male and female rats following oral mavoglurant administration. F, G. Locomotion in the ( F) first hour and ( G ) 6 h session in male and female rats following oral mavoglurant administration. The data are expressed as the mean ± SEM. n = 9 males (blue symbols), 7 females (red symbols). + p < 0.05, ++ p < 0.01, +++ p < 0.001, difference from session 1, regardless of sex; * p < 0.05, ** p < 0.01, difference from 0 mg/kg. IV, intravenous; SA, self-administration; ShA, short-access; FR1, fixed-ratio 1

Article Snippet: For oral administration, mavoglurant was purchased from MedChemExpress (catalog no. HY-15,257, Monmouth Junction, NJ, USA) and suspended in 0.5% methylcellulose in water and administered at doses of 0, 1, 3, 10 mg/kg 60 min before behavioral testing.

Techniques: