HY-126325 Search Results


gne 2861  (MedChemExpress)
94
MedChemExpress gne 2861
Structure of PAK inhibitors and control drugs. ( A ). KPT-9274, bearing a pyridine core. ( B ) PF-3758309, bearing an imidazole and a pyrazole. ( C ) Other PAK4 inhibitors <t>(GNE-2861</t> and LCH-7749944) bearing pyrimidines and their benzo derivative. ( D ) FRAX486, a group I PAK inhibitor that also partially inhibits PAK4, bears an imidazole. ( E ) PAK1 inhibitor IPA-3; ( F , G ) MEK inhibitors BI-847325 and PD0325901; ( H ) NAMPT inhibitor FK866; ( I ) Phloretin, a compound without imidazole and pyrazole, unlike PAK4 inhibitors. Based on the chemical structures, the pyrimidines or benzo derivatives in PAK4 inhibitors are predicted to bind to NAMPT or PAK4. The groups that interact with NAMPT are highlighted with green circles.
Gne 2861, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/HY-126325/GNE+2861/pmc11431865-176-3-13
Average 94 stars, based on 1 article reviews
gne 2861 - by Bioz Stars, 2026-09
94/100 stars
  Buy from Supplier
azd9898  (MedChemExpress)
94
MedChemExpress azd9898
a–c Representative plots and quantification of papain⁺ mDCs in mLN of mice co-treated or not with LPS and/or the LTC4S inhibitor <t>AZD9898</t> ( n = 5 mice per group). d–g Schematic of OTII cell transfer and treatments ( d ), representative plots of donor OTII cells in mLN ( e ), and quantification of OTII cells ( f , g ) ( n = 5 mice per group). h , i Schematic of treatments ( h ) and representative plots and quantification of Th2 cells in lung ( i ) ( n = 5 mice per group). j , k Schematic of OTII cell transfer and treatments ( j ), and representative plots and quantification of papain⁺ mDCs ( n = 4 mice per group) and donor OTII cells ( n = 5 mice per group) in mLN ( k ). l–n Schematic of treatments ( l ), representative plots and quantification of Th2 cells ( m ), and eosinophils ( n ) in the lung ( n = 5 mice per group). ( b , f , i , k , m , n ) Statistical tests are a two-tailed unpaired t -test. b ** p = 0.0021. f *** p = 0.0002. i *** p = 0.0007 left; *** p = 0.0002 right. k * p = 0.0406; ** p = 0.0014. m ** p = 0.0017 left; ** p = 0.0018 center; **** p < 0.0001. n ** p = 0.0049; *** p = 0.0008. Individual data points represent biological replicates, and bars show the mean ± SEM. Source data are provided in the Source Data file. Representative experiments of two were performed.
Azd9898, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/HY-126325/AZD9898/pmc12929616-338-19-20
Average 94 stars, based on 1 article reviews
azd9898 - by Bioz Stars, 2026-09
94/100 stars
  Buy from Supplier

Image Search Results


Structure of PAK inhibitors and control drugs. ( A ). KPT-9274, bearing a pyridine core. ( B ) PF-3758309, bearing an imidazole and a pyrazole. ( C ) Other PAK4 inhibitors (GNE-2861 and LCH-7749944) bearing pyrimidines and their benzo derivative. ( D ) FRAX486, a group I PAK inhibitor that also partially inhibits PAK4, bears an imidazole. ( E ) PAK1 inhibitor IPA-3; ( F , G ) MEK inhibitors BI-847325 and PD0325901; ( H ) NAMPT inhibitor FK866; ( I ) Phloretin, a compound without imidazole and pyrazole, unlike PAK4 inhibitors. Based on the chemical structures, the pyrimidines or benzo derivatives in PAK4 inhibitors are predicted to bind to NAMPT or PAK4. The groups that interact with NAMPT are highlighted with green circles.

Journal: International Journal of Molecular Sciences

Article Title: Inhibition of NAMPT by PAK4 Inhibitors

doi: 10.3390/ijms251810138

Figure Lengend Snippet: Structure of PAK inhibitors and control drugs. ( A ). KPT-9274, bearing a pyridine core. ( B ) PF-3758309, bearing an imidazole and a pyrazole. ( C ) Other PAK4 inhibitors (GNE-2861 and LCH-7749944) bearing pyrimidines and their benzo derivative. ( D ) FRAX486, a group I PAK inhibitor that also partially inhibits PAK4, bears an imidazole. ( E ) PAK1 inhibitor IPA-3; ( F , G ) MEK inhibitors BI-847325 and PD0325901; ( H ) NAMPT inhibitor FK866; ( I ) Phloretin, a compound without imidazole and pyrazole, unlike PAK4 inhibitors. Based on the chemical structures, the pyrimidines or benzo derivatives in PAK4 inhibitors are predicted to bind to NAMPT or PAK4. The groups that interact with NAMPT are highlighted with green circles.

Article Snippet: PF-3758309, FRAX486, IPA-3, GNE-2861, LCH-7749944, BI-847325, mirdametinib (PD0325901), and phloretin were purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA) and were dissolved in DMSO.

Techniques: Control

The predicted interactions between different drugs and the PAK4 protein. (1) PAK4 inhibitors: ( A ) KPT-9274, ( B ) PF-3758309, ( C ) GNE-2861, and ( D ) LCH-7749944. (2) PAK1 inhibitors: ( E ) FRAX486 and ( F ) IPA-3. (3) MEK inhibitors: ( G ) BI-847325 and ( H ) PD0325901 (mirdametinib). (4) Positive control ( I ) FK866 and negative control ( J ) phloretin.

Journal: International Journal of Molecular Sciences

Article Title: Inhibition of NAMPT by PAK4 Inhibitors

doi: 10.3390/ijms251810138

Figure Lengend Snippet: The predicted interactions between different drugs and the PAK4 protein. (1) PAK4 inhibitors: ( A ) KPT-9274, ( B ) PF-3758309, ( C ) GNE-2861, and ( D ) LCH-7749944. (2) PAK1 inhibitors: ( E ) FRAX486 and ( F ) IPA-3. (3) MEK inhibitors: ( G ) BI-847325 and ( H ) PD0325901 (mirdametinib). (4) Positive control ( I ) FK866 and negative control ( J ) phloretin.

Article Snippet: PF-3758309, FRAX486, IPA-3, GNE-2861, LCH-7749944, BI-847325, mirdametinib (PD0325901), and phloretin were purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA) and were dissolved in DMSO.

Techniques: Positive Control, Negative Control

The predicted interactions between different drugs and the NAMPT protein. (1) PAK4 inhibitors: ( A ) KPT-9274, ( B ) PF-3758309, ( C ) GNE-2861, and ( D ) LCH-7749944. (2) PAK1 inhibitors: ( E ) FRAX486 and ( F ) IPA-3. (3) MEK inhibitors: ( G ) BI-847325 and ( H ) PD0325901 (mirdametinib). (4) Positive control ( I ) FK866 and negative control ( J ) phloretin. The results show that PAK4 inhibitors are predicted to interact with PAK4 via pyrimidines and their benzo derivatives. The different positions of nitrogen on the benzene will affect the electrostatic interactions with an -NH bond and may lead to varying levels of NAMPT inhibition. PAK1 inhibitors (IPA-3) do not have the same groups, which may explain why they are less efficient at inhibiting NAMPT.

Journal: International Journal of Molecular Sciences

Article Title: Inhibition of NAMPT by PAK4 Inhibitors

doi: 10.3390/ijms251810138

Figure Lengend Snippet: The predicted interactions between different drugs and the NAMPT protein. (1) PAK4 inhibitors: ( A ) KPT-9274, ( B ) PF-3758309, ( C ) GNE-2861, and ( D ) LCH-7749944. (2) PAK1 inhibitors: ( E ) FRAX486 and ( F ) IPA-3. (3) MEK inhibitors: ( G ) BI-847325 and ( H ) PD0325901 (mirdametinib). (4) Positive control ( I ) FK866 and negative control ( J ) phloretin. The results show that PAK4 inhibitors are predicted to interact with PAK4 via pyrimidines and their benzo derivatives. The different positions of nitrogen on the benzene will affect the electrostatic interactions with an -NH bond and may lead to varying levels of NAMPT inhibition. PAK1 inhibitors (IPA-3) do not have the same groups, which may explain why they are less efficient at inhibiting NAMPT.

Article Snippet: PF-3758309, FRAX486, IPA-3, GNE-2861, LCH-7749944, BI-847325, mirdametinib (PD0325901), and phloretin were purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA) and were dissolved in DMSO.

Techniques: Positive Control, Negative Control, Inhibition

a–c Representative plots and quantification of papain⁺ mDCs in mLN of mice co-treated or not with LPS and/or the LTC4S inhibitor AZD9898 ( n = 5 mice per group). d–g Schematic of OTII cell transfer and treatments ( d ), representative plots of donor OTII cells in mLN ( e ), and quantification of OTII cells ( f , g ) ( n = 5 mice per group). h , i Schematic of treatments ( h ) and representative plots and quantification of Th2 cells in lung ( i ) ( n = 5 mice per group). j , k Schematic of OTII cell transfer and treatments ( j ), and representative plots and quantification of papain⁺ mDCs ( n = 4 mice per group) and donor OTII cells ( n = 5 mice per group) in mLN ( k ). l–n Schematic of treatments ( l ), representative plots and quantification of Th2 cells ( m ), and eosinophils ( n ) in the lung ( n = 5 mice per group). ( b , f , i , k , m , n ) Statistical tests are a two-tailed unpaired t -test. b ** p = 0.0021. f *** p = 0.0002. i *** p = 0.0007 left; *** p = 0.0002 right. k * p = 0.0406; ** p = 0.0014. m ** p = 0.0017 left; ** p = 0.0018 center; **** p < 0.0001. n ** p = 0.0049; *** p = 0.0008. Individual data points represent biological replicates, and bars show the mean ± SEM. Source data are provided in the Source Data file. Representative experiments of two were performed.

Journal: Nature Communications

Article Title: Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung

doi: 10.1038/s41467-026-68652-5

Figure Lengend Snippet: a–c Representative plots and quantification of papain⁺ mDCs in mLN of mice co-treated or not with LPS and/or the LTC4S inhibitor AZD9898 ( n = 5 mice per group). d–g Schematic of OTII cell transfer and treatments ( d ), representative plots of donor OTII cells in mLN ( e ), and quantification of OTII cells ( f , g ) ( n = 5 mice per group). h , i Schematic of treatments ( h ) and representative plots and quantification of Th2 cells in lung ( i ) ( n = 5 mice per group). j , k Schematic of OTII cell transfer and treatments ( j ), and representative plots and quantification of papain⁺ mDCs ( n = 4 mice per group) and donor OTII cells ( n = 5 mice per group) in mLN ( k ). l–n Schematic of treatments ( l ), representative plots and quantification of Th2 cells ( m ), and eosinophils ( n ) in the lung ( n = 5 mice per group). ( b , f , i , k , m , n ) Statistical tests are a two-tailed unpaired t -test. b ** p = 0.0021. f *** p = 0.0002. i *** p = 0.0007 left; *** p = 0.0002 right. k * p = 0.0406; ** p = 0.0014. m ** p = 0.0017 left; ** p = 0.0018 center; **** p < 0.0001. n ** p = 0.0049; *** p = 0.0008. Individual data points represent biological replicates, and bars show the mean ± SEM. Source data are provided in the Source Data file. Representative experiments of two were performed.

Article Snippet: In some experiments, mice received i.p. administration of 200 μL of 2.5 mg/mL EDU (Invitrogen) or 200 μg of AZD9898 (MedChem Express).

Techniques: Two Tailed Test