HY-103615 Search Results


pkm2  (MedChemExpress)
93
MedChemExpress pkm2
CLIC1 promotes gastric cancer progression by modulating <t>PKM2-mediated</t> glycolysis. ( A ) WB analysis demonstrated PKM2 protein <t>expression</t> <t>following</t> <t>PKM2-IN-1</t> treatment in AGS and HGC27 cells. ( B – C ) Quantification of lactate production ( B ) and glucose consumption ( C ) in control and CLIC1-overexpressing AGS and HGC27 cells with or without PKM2-IN-1 treatment. ( D ) CCK-8 assay showed that CLIC1 overexpression enhanced gastric cancer cell proliferation, whereas PKM2-IN-1 partially reversed this effect. ( E – H ) Representative images and quantitative analysis of wound-healing assays. ( I – L ) Representative images and statistical quantification of transwell migration and invasion assays. One-way ANOVA (* p < 0.05, ** p < 0.01, *** p < 0.001)
Pkm2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pkm2/product/MedChemExpress
Average 93 stars, based on 1 article reviews
pkm2 - by Bioz Stars, 2026-02
93/100 stars
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thz531  (MedChemExpress)
93
MedChemExpress thz531
CLIC1 promotes gastric cancer progression by modulating <t>PKM2-mediated</t> glycolysis. ( A ) WB analysis demonstrated PKM2 protein <t>expression</t> <t>following</t> <t>PKM2-IN-1</t> treatment in AGS and HGC27 cells. ( B – C ) Quantification of lactate production ( B ) and glucose consumption ( C ) in control and CLIC1-overexpressing AGS and HGC27 cells with or without PKM2-IN-1 treatment. ( D ) CCK-8 assay showed that CLIC1 overexpression enhanced gastric cancer cell proliferation, whereas PKM2-IN-1 partially reversed this effect. ( E – H ) Representative images and quantitative analysis of wound-healing assays. ( I – L ) Representative images and statistical quantification of transwell migration and invasion assays. One-way ANOVA (* p < 0.05, ** p < 0.01, *** p < 0.001)
Thz531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/thz531/product/MedChemExpress
Average 93 stars, based on 1 article reviews
thz531 - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
thalidomide o amido c8 nh2 trifluoroacetic acid salt  (MedChemExpress)
90
MedChemExpress thalidomide o amido c8 nh2 trifluoroacetic acid salt
CLIC1 promotes gastric cancer progression by modulating <t>PKM2-mediated</t> glycolysis. ( A ) WB analysis demonstrated PKM2 protein <t>expression</t> <t>following</t> <t>PKM2-IN-1</t> treatment in AGS and HGC27 cells. ( B – C ) Quantification of lactate production ( B ) and glucose consumption ( C ) in control and CLIC1-overexpressing AGS and HGC27 cells with or without PKM2-IN-1 treatment. ( D ) CCK-8 assay showed that CLIC1 overexpression enhanced gastric cancer cell proliferation, whereas PKM2-IN-1 partially reversed this effect. ( E – H ) Representative images and quantitative analysis of wound-healing assays. ( I – L ) Representative images and statistical quantification of transwell migration and invasion assays. One-way ANOVA (* p < 0.05, ** p < 0.01, *** p < 0.001)
Thalidomide O Amido C8 Nh2 Trifluoroacetic Acid Salt, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/thalidomide o amido c8 nh2 trifluoroacetic acid salt/product/MedChemExpress
Average 90 stars, based on 1 article reviews
thalidomide o amido c8 nh2 trifluoroacetic acid salt - by Bioz Stars, 2026-02
90/100 stars
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thalidomide-o-amido-c4-n3  (MedChemExpress)
N/A
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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Image Search Results


CLIC1 promotes gastric cancer progression by modulating PKM2-mediated glycolysis. ( A ) WB analysis demonstrated PKM2 protein expression following PKM2-IN-1 treatment in AGS and HGC27 cells. ( B – C ) Quantification of lactate production ( B ) and glucose consumption ( C ) in control and CLIC1-overexpressing AGS and HGC27 cells with or without PKM2-IN-1 treatment. ( D ) CCK-8 assay showed that CLIC1 overexpression enhanced gastric cancer cell proliferation, whereas PKM2-IN-1 partially reversed this effect. ( E – H ) Representative images and quantitative analysis of wound-healing assays. ( I – L ) Representative images and statistical quantification of transwell migration and invasion assays. One-way ANOVA (* p < 0.05, ** p < 0.01, *** p < 0.001)

Journal: Journal of Translational Medicine

Article Title: The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression

doi: 10.1186/s12967-025-07463-6

Figure Lengend Snippet: CLIC1 promotes gastric cancer progression by modulating PKM2-mediated glycolysis. ( A ) WB analysis demonstrated PKM2 protein expression following PKM2-IN-1 treatment in AGS and HGC27 cells. ( B – C ) Quantification of lactate production ( B ) and glucose consumption ( C ) in control and CLIC1-overexpressing AGS and HGC27 cells with or without PKM2-IN-1 treatment. ( D ) CCK-8 assay showed that CLIC1 overexpression enhanced gastric cancer cell proliferation, whereas PKM2-IN-1 partially reversed this effect. ( E – H ) Representative images and quantitative analysis of wound-healing assays. ( I – L ) Representative images and statistical quantification of transwell migration and invasion assays. One-way ANOVA (* p < 0.05, ** p < 0.01, *** p < 0.001)

Article Snippet: 2-deoxy-D-glucose (2-DG, MCE, HY-13966, USA) and PKM2-IN-1 (MCE, HY-103617, USA) were applied to the cells to assess cell proliferation.

Techniques: Expressing, Control, CCK-8 Assay, Over Expression, Migration

CLIC1 promotes gastric tumor growth through PKM2-dependent glycolysis in vivo. ( A ) Representative xenograft tumors from each group at the endpoint. ( B ) Tumor weights showed that PKM2-IN-1 treatment attenuated CLIC1-induced tumor growth. ( C ) Tumor growth curves depicted the kinetics of tumor volume expansion over time in each experimental group. ( D ) Representative IHC staining of CLIC1 and PKM2 in tumor tissues. One-way ANOVA. (* p < 0.05, ** p < 0.01, *** p < 0.001)

Journal: Journal of Translational Medicine

Article Title: The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression

doi: 10.1186/s12967-025-07463-6

Figure Lengend Snippet: CLIC1 promotes gastric tumor growth through PKM2-dependent glycolysis in vivo. ( A ) Representative xenograft tumors from each group at the endpoint. ( B ) Tumor weights showed that PKM2-IN-1 treatment attenuated CLIC1-induced tumor growth. ( C ) Tumor growth curves depicted the kinetics of tumor volume expansion over time in each experimental group. ( D ) Representative IHC staining of CLIC1 and PKM2 in tumor tissues. One-way ANOVA. (* p < 0.05, ** p < 0.01, *** p < 0.001)

Article Snippet: 2-deoxy-D-glucose (2-DG, MCE, HY-13966, USA) and PKM2-IN-1 (MCE, HY-103617, USA) were applied to the cells to assess cell proliferation.

Techniques: In Vivo, Immunohistochemistry