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NSJ Bioreagents
anti zdhhc21  Anti Zdhhc21, supplied by NSJ Bioreagents, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/anti zdhhc21/product/NSJ Bioreagents Average 94 stars, based on 1 article reviews
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2026-02
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EDG6 / S1PR4 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of
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EEF1A1 is an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta,
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such as arthritis
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as
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EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder,
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When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5),
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Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia
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STAMBPL1 is zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
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MFRN2 is mitochondrial iron transporter that mediates iron uptake. It is probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is
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Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects
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HSP90B1 is highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized
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Image Search Results
Journal: bioRxiv
Article Title: Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse
doi: 10.64898/2026.01.19.700329
Figure Lengend Snippet: ZDHHC21 acyltransferase mediates Kv1.3 palmitoylation. (A) Orthogonal views of a representative synapse conjugate between a CD4 + T cell and a Raji B cell immunostained with an anti-ZDHHC21 antibody. Three-dimensional reconstruction revealed the distribution of the acyltransferases in both lymphocytes. (B) Top panel, schematic of the image processing for the visualization of ZDHHC21 at the synaptic platform in (A). In the bottom panel, intensities from the stacks corresponding to 3 µm of the synaptic region were compiled in a single Z projection. Note that, similar to Kv1.3, ZDHHC21 organizes as a distal ring with partial accumulation at the center of the synapse. The scale bar represents 5 μm. (C) Representative confocal images of synapse conjugates between CD4 + T cells and Raji B cells. Immunostaining of endogenous Kv1.3, ZDHHC21, CD3 (T cells), and CD19 (B cells) was performed. Merged panels show colocalization between Kv1.3 and ZDHHC21 (top) and between CD3 and ZDHHC21 (bottom). Colocalized pixels identified by Otsu’s automatic thresholding are displayed to facilitate visualization. The scale bar represents 5 μm. (D) Representative regions of interest (ROIs) inside and outside the IS regions were manually identified using the CD3 and CD19 masks. Right panel, Manders overlap coefficient (MOC) between Kv1.3 and ZDHHC21 inside and outside the IS. Data are presented as the mean ± SE of 5 cells from the same donor. **p < 0.01 by Student’s t test. (E) Representative Western blot of ZDHHC21-silenced CD4 + T cells. Lymphocytes were electroporated with ZDHHC21 siRNA, and after a 48-h incubation, whole-cell lysates were analyzed by Western blotting. β-actin was used as a loading control. CTRL: control, untreated cells. (F) Representative Western blot of Kv1.3 palmitoylation in CTRL- or ZDHHC21-knockdown (siRNA) CD4 + T cells. Flotillin was used as a positive control. SM: starting materials, PD: pull-down, HA - : negative control. (G) Quantification of Kv1.3 palmitoylation under basal conditions (CTRL) and after ZDHHC21 silencing (siRNA). The data were normalized to those of the CTRL. The data are presented as the means ± SEs of 3 independent donors. ***p < 0.001 by Student’s t test.
Article Snippet: Next, the cells were labeled with primary anti-CD3 (Alexa Fluor 647; Biolegend), anti-CD19 (Brilliant Violet 421; Biolegend),
Techniques: Immunostaining, Western Blot, Incubation, Control, Knockdown, Positive Control, Negative Control