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Bio-Rad
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This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed
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The Mouse LRPAP Antibody from R D Systems is a sheep polyclonal antibody to LRPAP This antibody reacts with mouse The Mouse LRPAP Antibody has been validated for the following applications Western Blot
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as
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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.
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This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate
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Image Search Results
Journal: Cell Death & Disease
Article Title: Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells
doi: 10.1038/s41419-021-03978-0
Figure Lengend Snippet: a NSCLC and HGSOC cell lines were treated with indicated concentrations of carboplatin and STL alone or in combination for 48 h. b PEO1 cells with stable FOXM1 knockdown were treated with indicated concentrations of carboplatin and STL alone or in combination for 48 h. c Colorectal cancer cell lines were treated with indicated concentrations of 5-FU and STL alone or in combination for 24 h. d Prostate cancer and NSCLC cell lines were treated with indicated concentrations of docetaxel, paclitaxel, and STL alone or in combination for 24 h. In all cases, total protein samples were obtained from cells immediately after treatment and analyzed for FOXM1, cleaved caspase-3 and LC3 levels via immunoblotting, β-actin was used as an internal loading control.
Article Snippet: STL427944 (Vitas-M Laboratory, Hong Kong), actinomycin D (ActD, MilliporeSigma, Burlington, MA, USA), cycloheximide (CHX, MilliporeSigma), bafilomycin A1 (BafA1, AdipoGen Life Sciences, San Diego, CA, USA), bortezomib (APExBIO Technology, Houston, TX, USA), MG132 (Tocris Bioscience, Minneapolis, MN, USA), docetaxel (APExBIO Technology), paclitaxel (APExBIO Technology), and
Techniques: Western Blot