Databases Search Results


94
Transnetyx breeding colony
Breeding Colony, supplied by Transnetyx, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/breeding colony/product/Transnetyx
Average 94 stars, based on 1 article reviews
breeding colony - by Bioz Stars, 2026-04
94/100 stars
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97
Akoya Biosciences cd21 bx032
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Cd21 Bx032, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cd21 bx032/product/Akoya Biosciences
Average 97 stars, based on 1 article reviews
cd21 bx032 - by Bioz Stars, 2026-04
97/100 stars
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96
MathWorks Inc r2017b mathworks
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
R2017b Mathworks, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/r2017b mathworks/product/MathWorks Inc
Average 96 stars, based on 1 article reviews
r2017b mathworks - by Bioz Stars, 2026-04
96/100 stars
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99
Bruker Corporation mbt compass library database revision 2020
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Mbt Compass Library Database Revision 2020, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mbt compass library database revision 2020/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
mbt compass library database revision 2020 - by Bioz Stars, 2026-04
99/100 stars
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99
Evident Corporation database manual cell sens life science imaging software system
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Database Manual Cell Sens Life Science Imaging Software System, supplied by Evident Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/database manual cell sens life science imaging software system/product/Evident Corporation
Average 99 stars, based on 1 article reviews
database manual cell sens life science imaging software system - by Bioz Stars, 2026-04
99/100 stars
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96
Bruker Corporation bbiorefcode database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Bbiorefcode Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bbiorefcode database/product/Bruker Corporation
Average 96 stars, based on 1 article reviews
bbiorefcode database - by Bioz Stars, 2026-04
96/100 stars
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99
Bruker Corporation mbt compass ht database v5 1 300
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Mbt Compass Ht Database V5 1 300, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mbt compass ht database v5 1 300/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
mbt compass ht database v5 1 300 - by Bioz Stars, 2026-04
99/100 stars
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99
Bruker Corporation bio typer database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Bio Typer Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bio typer database/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
bio typer database - by Bioz Stars, 2026-04
99/100 stars
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99
Bruker Corporation mbt database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Mbt Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mbt database/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
mbt database - by Bioz Stars, 2026-04
99/100 stars
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99
Bruker Corporation maldi biotyper bruker taxonomy database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Maldi Biotyper Bruker Taxonomy Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/maldi biotyper bruker taxonomy database/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
maldi biotyper bruker taxonomy database - by Bioz Stars, 2026-04
99/100 stars
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99
Bruker Corporation bdal database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Bdal Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bdal database/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
bdal database - by Bioz Stars, 2026-04
99/100 stars
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99
Bruker Corporation legionella database
FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of <t>CD21</t> (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.
Legionella Database, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/legionella database/product/Bruker Corporation
Average 99 stars, based on 1 article reviews
legionella database - by Bioz Stars, 2026-04
99/100 stars
  Buy from Supplier

Image Search Results


FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of CD21 (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.

Journal: Cell Reports Medicine

Article Title: Follicular lymphoma B cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments

doi: 10.1016/j.xcrm.2024.101443

Figure Lengend Snippet: FL B cell states shape their local immune profile (A) Uniform manifold approximation and projection of immune metaclusters from individually profiled FL patient CyTOF samples (n = 60). Clusters identified using Phenograph and are colored by manual annotation. (B) Heatmap of mean surface protein expression in each identified cluster mentioned in (A). Cluster identities listed next to their coordinating colors from (A). (C) Boxplot of immune content as percentage of live cells in each sample by their B cell group. (D) Correlation plot between the difference in CMI vs. INFM state coefficients (positive = higher CMI, negative = higher INFM) and the non-B immune cell percentage (% of live cells). A standard linear regression line is displayed with 95% CIs, along with ( r ) Pearson correlation, and representative p value. (E) (Left) Heatmap of correlation matrix between cell cluster abundances in all of the samples, depicting cellular communities (black boxes). Cell values from Pearson correlation. Dendrogram from correlation distance. (Right) Heatmap of Pearson correlation between cell abundance and sample B cell group state. Pearson p values are printed where p < 0.1. (F) Heatmap of Spearman correlation between single-sample gene set scoring, using SingScore of published GC stromal gene sets, and B cell group states (n = 54). Pearson p values are printed in cells where p < 0.1. (G) CODEX multiplexed immunofluorescence analysis of CD21 (white), CD20 (blue), Ki-67 (yellow), CD4 (green), and CD8 (magenta) on 1 sample from each B cell group. (Left) Baseline cell type abundance in each sample (% of live) from CyTOF. (Right) First 3 panels, stitched images equal to 10× magnification with 500-μm scale. White box delineating the magnified view in panel 4 of follicle and interfollicular region, with 200-μm scale.

Article Snippet: CD21-BX032 (EP3093)—Atto 550-RX032 , Akoya , Catalog: 4450027.

Techniques: Expressing, Immunofluorescence

Journal: Cell Reports Medicine

Article Title: Follicular lymphoma B cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments

doi: 10.1016/j.xcrm.2024.101443

Figure Lengend Snippet:

Article Snippet: CD21-BX032 (EP3093)—Atto 550-RX032 , Akoya , Catalog: 4450027.

Techniques: Cell Isolation, Software, Multiplex Assay