Journal:

Article Title: Cloning and DNA Sequence Analysis of an Immunogenic Glucose-Galactose MglB Lipoprotein Homologue from Brachyspira pilosicolithe Agent of Colonic Spirochetosis

doi:

Figure Lengend Snippet: Sources, origins, and presence of B. pilosicoli mglB gene homologue among intestinal spirochetes

Article Snippet: B256 (ATCC 29786) , Pig/U.S. , − , 5.

Techniques:

Journal: ACS infectious diseases

Article Title: Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria

doi: 10.1021/acsinfecdis.9b00212

Figure Lengend Snippet: Colistin MIC ( μ g/mL (Fold Reduction)) of 11 Gram-Negative Strains of A. baumannii (AB), E. coli (EC), K. pneumoniae (KP), and P. aeruginosa (PA) Codosed with 5 μ M Adjuvant and Colistin a

Article Snippet: Here, we see no perturbance of growth in the presence of compound alone and, in dual therapy, antimicrobial activity of colistin at concentrations well below each strain’s respective colistin MIC. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 2. caption a7 Structures of adjuvants utilized in postscreen follow-up experiments: sorafenib ( 9 ); AG 879 ( 10 ); 6-bromoindirubin-3-oxime (BIO) ( 11 ); IMD-0354 ( 12 ); OSU-03012 (AR-12) ( 13 ); NVP-BAG956 ( 14 ); celecoxib ( 15 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3. caption a7 Bacterial growth over time for AB 4106 and KP B9 alone and treated with 5 μ M 12 only or 5 μ M 12 in combination with colistin at the denoted concentrations. table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 colistin MIC ( μ g/mL) 9 10 11 12 13 AB 3941 512 64 (8) 64 (8) 256 (2) 1 (512) 512 (2) AB 3942 512 32 (16) 64 (8) 128 (4) 2 (256) 512 (0) AB 4106 1024 64 (16) 64 (16) 128 (8) 1 (1024) 512 (2) AB 4112 >1024 64 (>16) 64 (>16) 256 (>4) 1 (>1024) b 1024 (>0) KP A5 >1024 >1024 (0) >1024 (0) 256 (>4) 8 (>128) b >1024 (0) KP B9 1024 2 (512) 512 (2) 0.5 (2048) 0.25 (4096) b 256 (4) KP C3 256 4 (64) 256 (0) 1 (256) 1 (256) b 256 (2) AB ATCC 17978 + mcr -1 16 2 (8) 16 (0) 16 (0) 0.0625 (256) c 16 (0) EC ATCC 25922 + mcr -1 8 1 (8) 8 (0) 1 (8) 0.25 (64) c 4 (2) KP 2210291 + mcr -1 16 8 (2) 16 (0) 4 (4) 0.5 (32) 16 (0) PA ATCC 47085 + mcr -1 4 4 (0) 4 (0) 4 (0) 2 (2) 2 (2) AB ATCC 17978 1 0.5 (2) 0.5 (2) 1 (0) 1 (0) c 0.5 (2) EC ATCC 25922 0.5 0.5 (0) 0.5 (0) 0.5 (0) 0.5 (0) b 0.5 (0) KP 2210291 1 0.5 (2) 1 (0) 0.5 (2) 0.5 (2) 0.25 (4) PA ATCC 47085 2 1 (2) 2 (0) 2 (0) 1 (2) 1 (2) Open in a separate window a All adjuvant MICs are >200 μ M unless noted. b Compound MIC = 200 μ M. c Compound MIC = 100 μ M. Colistin MIC ( μ g/mL (Fold Reduction)) of 11 Gram-Negative Strains of A. baumannii (AB), E. coli (EC), K. pneumoniae (KP), and P. aeruginosa (PA) Codosed with 5 μ M Adjuvant and Colistin a table ft1 table-wrap mode="anchored" t5 Table 2. caption a7 AB 4106 KP B9 compound MIC >200 μ M 200 μ M colistin MIC 1024 μ g/mL 1024 μ g/mL colistin + 10 μ M 0.5 (2048) 0.0625 (>4096) colistin + 7.5 μ M 1 (1024) 0.25 (4096) colistin + 5 μ M 1 (1024) 0.25 (4096) colistin + 2 μ M 4 (256) 1 (1024) colistin + 1 μ M 8 (128) 4 (256) Open in a separate window Colistin MIC ( μ g/mL (Fold Reduction)) of AB 4106 and KP B9 Treated with 12 at Various Concentrations

Techniques:

Journal:

Article Title: Cloning and DNA Sequence Analysis of an Immunogenic Glucose-Galactose MglB Lipoprotein Homologue from Brachyspira pilosicolithe Agent of Colonic Spirochetosis

doi:

Figure Lengend Snippet: Sources, origins, and presence of B. pilosicoli mglB gene homologue among intestinal spirochetes

Article Snippet: − 2 889 Pig/Australia + 3 AN26:93 Pig/Sweden + 4 B. innocens B256 (ATCC 29786) Pig/U.S.

Techniques: