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    • swell1  (Alomone Labs)
    93
    Alomone Labs swell1
    Caveolar macromolecular mechanosensitive complex. Immunofluorescent analysis of colocalized expression of ClC‐3 (left), ClC‐2 (middle), and SWELL 1 (right) chloride channels with caveolae scaffolding protein Cav3 (caveolin 3) in nonstretched rat pulmonary vein distal ( PV dis ; A ) and human left atrium ( B ) myocardium. For colocalization analysis, intensity level of 30% was used as a threshold. Cav3 indicates caveolin 3; ClC, chloride channel; <t>SWELL1,</t> also known as <t>LRRC8A</t> (leucine rich repeat containing protein 8A).
    Swell1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/swell1/product/Alomone Labs
    Average 93 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    swell1 - by Bioz Stars, 2023-10
    93/100 stars
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    aac 001 trial  (Johnson & Johnson)
    86
    Johnson & Johnson aac 001 trial
    Caveolar macromolecular mechanosensitive complex. Immunofluorescent analysis of colocalized expression of ClC‐3 (left), ClC‐2 (middle), and SWELL 1 (right) chloride channels with caveolae scaffolding protein Cav3 (caveolin 3) in nonstretched rat pulmonary vein distal ( PV dis ; A ) and human left atrium ( B ) myocardium. For colocalization analysis, intensity level of 30% was used as a threshold. Cav3 indicates caveolin 3; ClC, chloride channel; <t>SWELL1,</t> also known as <t>LRRC8A</t> (leucine rich repeat containing protein 8A).
    Aac 001 Trial, supplied by Johnson & Johnson, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aac 001 trial/product/Johnson & Johnson
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    aac 001 trial - by Bioz Stars, 2023-10
    86/100 stars
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    aβ immuno conjugate aac 001  (Wyeth Biopharma)
    86
    Wyeth Biopharma aβ immuno conjugate aac 001
    Caveolar macromolecular mechanosensitive complex. Immunofluorescent analysis of colocalized expression of ClC‐3 (left), ClC‐2 (middle), and SWELL 1 (right) chloride channels with caveolae scaffolding protein Cav3 (caveolin 3) in nonstretched rat pulmonary vein distal ( PV dis ; A ) and human left atrium ( B ) myocardium. For colocalization analysis, intensity level of 30% was used as a threshold. Cav3 indicates caveolin 3; ClC, chloride channel; <t>SWELL1,</t> also known as <t>LRRC8A</t> (leucine rich repeat containing protein 8A).
    Aβ Immuno Conjugate Aac 001, supplied by Wyeth Biopharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aβ immuno conjugate aac 001/product/Wyeth Biopharma
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    aβ immuno conjugate aac 001 - by Bioz Stars, 2023-10
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Caveolar macromolecular mechanosensitive complex. Immunofluorescent analysis of colocalized expression of ClC‐3 (left), ClC‐2 (middle), and SWELL 1 (right) chloride channels with caveolae scaffolding protein Cav3 (caveolin 3) in nonstretched rat pulmonary vein distal ( PV dis ; A ) and human left atrium ( B ) myocardium. For colocalization analysis, intensity level of 30% was used as a threshold. Cav3 indicates caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis

    doi: 10.1161/JAHA.119.012748

    Figure Lengend Snippet: Caveolar macromolecular mechanosensitive complex. Immunofluorescent analysis of colocalized expression of ClC‐3 (left), ClC‐2 (middle), and SWELL 1 (right) chloride channels with caveolae scaffolding protein Cav3 (caveolin 3) in nonstretched rat pulmonary vein distal ( PV dis ; A ) and human left atrium ( B ) myocardium. For colocalization analysis, intensity level of 30% was used as a threshold. Cav3 indicates caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Article Snippet: Masson's trichrome staining and double‐immunolabeling for ClC‐2 (goat polyclonal; SAB2501373, Sigma‐Aldrich), ClC‐3 (rabbit polyclonal; ACL‐001, Alomone Labs), SWELL1 (anti‐LRRC8A, rabbit polyclonal; AAC‐001, Alomone Labs), and Cav3 (mouse monoclonal; 610421, BD Biosciences; rabbit polyclonal; ab2912, Abcam) were performed on paraffin‐embedded sections of unstretched PV preparations.

    Techniques: Expressing, Scaffolding

    Co‐IP Western blots showing degree of association of Cav3 and chloride channels ClC‐2, ClC‐3, and SWELL 1 in rat pulmonary vein ( PV ; n=2). IB indicates immunoblot; IP , immunoprecipitation. Cav3 indicates caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis

    doi: 10.1161/JAHA.119.012748

    Figure Lengend Snippet: Co‐IP Western blots showing degree of association of Cav3 and chloride channels ClC‐2, ClC‐3, and SWELL 1 in rat pulmonary vein ( PV ; n=2). IB indicates immunoblot; IP , immunoprecipitation. Cav3 indicates caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Article Snippet: Masson's trichrome staining and double‐immunolabeling for ClC‐2 (goat polyclonal; SAB2501373, Sigma‐Aldrich), ClC‐3 (rabbit polyclonal; ACL‐001, Alomone Labs), SWELL1 (anti‐LRRC8A, rabbit polyclonal; AAC‐001, Alomone Labs), and Cav3 (mouse monoclonal; 610421, BD Biosciences; rabbit polyclonal; ab2912, Abcam) were performed on paraffin‐embedded sections of unstretched PV preparations.

    Techniques: Co-Immunoprecipitation Assay, Western Blot, Immunoprecipitation

    Expression of chloride channels ClC‐2, ClC‐3, and SWELL 1, caveolar scaffolding protein caveolin 3 (Cav3), and potassium channel K ir 2.1 along the pulmonary vein ( PV ) vs left atrium ( LA ). A , Protein expression levels of K ir 2.1, ClC‐2, Cav3, ClC‐3, and SWELL 1 measured in PV distal ( PV dis ), PV ostium ( PV ost ), and LA from the same rat (n=4). B through F , Corresponding protein expression levels normalized to GAPDH (n=4 per group). ** P <0.01 by 1‐way ANOVA with Bonferroni correction. G , Comparative analysis of mRNA expression levels for sarcolemmal chloride ion channel isoforms normalized to GAPDH . n=6 per region for SWELL 1 and n=5 per region for ClC‐2, ClC‐3, and ANO 1. *** P <0.01 vs PV dis for SWELL 1; ## P <0.01, ### P <0.001 vs SWELL 1 for PV dis ; $$ P <0.01 vs ClC‐3 for PV dis ; and && P <0.01 vs ClC‐3 for LA by 2‐way ANOVA with Bonferroni correction. ANO 1 indicates anoctamin 1; Cav3, caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis

    doi: 10.1161/JAHA.119.012748

    Figure Lengend Snippet: Expression of chloride channels ClC‐2, ClC‐3, and SWELL 1, caveolar scaffolding protein caveolin 3 (Cav3), and potassium channel K ir 2.1 along the pulmonary vein ( PV ) vs left atrium ( LA ). A , Protein expression levels of K ir 2.1, ClC‐2, Cav3, ClC‐3, and SWELL 1 measured in PV distal ( PV dis ), PV ostium ( PV ost ), and LA from the same rat (n=4). B through F , Corresponding protein expression levels normalized to GAPDH (n=4 per group). ** P <0.01 by 1‐way ANOVA with Bonferroni correction. G , Comparative analysis of mRNA expression levels for sarcolemmal chloride ion channel isoforms normalized to GAPDH . n=6 per region for SWELL 1 and n=5 per region for ClC‐2, ClC‐3, and ANO 1. *** P <0.01 vs PV dis for SWELL 1; ## P <0.01, ### P <0.001 vs SWELL 1 for PV dis ; $$ P <0.01 vs ClC‐3 for PV dis ; and && P <0.01 vs ClC‐3 for LA by 2‐way ANOVA with Bonferroni correction. ANO 1 indicates anoctamin 1; Cav3, caveolin 3; ClC, chloride channel; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Article Snippet: Masson's trichrome staining and double‐immunolabeling for ClC‐2 (goat polyclonal; SAB2501373, Sigma‐Aldrich), ClC‐3 (rabbit polyclonal; ACL‐001, Alomone Labs), SWELL1 (anti‐LRRC8A, rabbit polyclonal; AAC‐001, Alomone Labs), and Cav3 (mouse monoclonal; 610421, BD Biosciences; rabbit polyclonal; ab2912, Abcam) were performed on paraffin‐embedded sections of unstretched PV preparations.

    Techniques: Expressing, Scaffolding

    Molecular and structural remodeling of caveolar mechanosensitive complex. A , Immunoblots for ClC‐2, ClC‐3, SWELL 1, and Cav3 from Wistar ( WT ; n=4) and spontaneously hypertensive rat ( SHR ; n=4) pulmonary vein distal ( PV dis ) tissues. Expression levels were normalized to GAPDH . P values were determined by unpaired Student t test. B , Downregulation of Cav3 correlates with elevated membrane tension and disruption of caveolae structures during hypertension. Representative composite electron micrographs showing the lateral sarcolemmal membranes of cardiomyocytes from nonstretched WT and SHR PV dis tissues. Blue arrowheads denote caveolae connected to plasma membrane (scale bars=200 nm). C and D , Quantification of caveolae density, normalized to membrane length ( C ), and membrane convolution index (L/L o −1) ( D ), n=40 cells per group. Box plots show medians with interquartile range; whiskers represent fifth and 95th percentile; each point represents 1 micrograph. P values were determined by unpaired Student t test. Cav3 indicates caveolin 3; ClC, chloride channel; L, length of membrane contour; L o , shortest length connecting end points of membrane segment; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis

    doi: 10.1161/JAHA.119.012748

    Figure Lengend Snippet: Molecular and structural remodeling of caveolar mechanosensitive complex. A , Immunoblots for ClC‐2, ClC‐3, SWELL 1, and Cav3 from Wistar ( WT ; n=4) and spontaneously hypertensive rat ( SHR ; n=4) pulmonary vein distal ( PV dis ) tissues. Expression levels were normalized to GAPDH . P values were determined by unpaired Student t test. B , Downregulation of Cav3 correlates with elevated membrane tension and disruption of caveolae structures during hypertension. Representative composite electron micrographs showing the lateral sarcolemmal membranes of cardiomyocytes from nonstretched WT and SHR PV dis tissues. Blue arrowheads denote caveolae connected to plasma membrane (scale bars=200 nm). C and D , Quantification of caveolae density, normalized to membrane length ( C ), and membrane convolution index (L/L o −1) ( D ), n=40 cells per group. Box plots show medians with interquartile range; whiskers represent fifth and 95th percentile; each point represents 1 micrograph. P values were determined by unpaired Student t test. Cav3 indicates caveolin 3; ClC, chloride channel; L, length of membrane contour; L o , shortest length connecting end points of membrane segment; SWELL1, also known as LRRC8A (leucine rich repeat containing protein 8A).

    Article Snippet: Masson's trichrome staining and double‐immunolabeling for ClC‐2 (goat polyclonal; SAB2501373, Sigma‐Aldrich), ClC‐3 (rabbit polyclonal; ACL‐001, Alomone Labs), SWELL1 (anti‐LRRC8A, rabbit polyclonal; AAC‐001, Alomone Labs), and Cav3 (mouse monoclonal; 610421, BD Biosciences; rabbit polyclonal; ab2912, Abcam) were performed on paraffin‐embedded sections of unstretched PV preparations.

    Techniques: Western Blot, Expressing