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Image Search Results
Journal: Journal of Antimicrobial Chemotherapy
Article Title: Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis
doi: 10.1093/jac/dkw588
Figure Lengend Snippet: Time–kill plots for specific strains and drug combinations. Methicillin-resistant S. aureus strains (W66, W146, N315, W21, W103, NRS4, W48), methicillin-resistant S. epidermidis (R2284, R2270), methicillin-susceptible S. epidermidis (ATCC 12228). TDZ, tedizolid; DOX, doxycycline; SXT, trimethoprim/sulfamethoxazole; MXF, moxifloxacin; RIF, rifampicin.
Article Snippet: TDZ, tedizolid; DOX, doxycycline; SXT, trimethoprim/sulfamethoxazole; MXF, moxifloxacin; RIF, rifampicin. table ft1 table-wrap mode="anchored" t5 Table 1 caption a7 MIC (mg/L) Tedizolid Doxycycline Trimethoprim/sulfamethoxazole Moxifloxacin Rifampicin MIC 50 0.25 0.25 0.13/2.38 2 0.02 MIC 90 0.5 8 4/76 16 4 Range 0.125–1 0.125–8 0.03/0.59–4/76 0.06–16 0.01–>32 Breakpoints ≤0.5 ≤1 ≤2/38 ≤0.5 ≤0.06 Open in a separate window Summary of staphylococcal strain susceptibilities, n = 45 table ft1 table-wrap mode="anchored" t5 Table 2 caption a7 Strain TDZ DOX Interaction b SXT Interaction b MXF Interaction b RIF Interaction MRSA W66 0.25 (S) 8 (NS) indifferent >4/76 (NS) indifferent 16 (NS) indifferent 4 (NS) indifferent W48 0.25 (S) 0.13 (S) synergy 0.06/1.19 (S) indifferent 0.0625 (S) indifferent ≤0.01 (S) synergy W146 0.25 (S) 0.25 (S) synergy >4/76 (NS) indifferent 4 (NS) antagonism >32 (NS) indifferent N315 0.25 (S) 0.125 (S) indifferent 0.125/2.38 (S) indifferent 0.0625 (S) indifferent ≤0.01 (S) synergy W21 0.5 (S) 0.5 (S) indifferent 0.06/1.19 (S) indifferent 2 (NS) antagonism ≤0.01 (S) indifferent W103 0.25 (S) 0.25 (S) indifferent 0.06/1.19 (S) indifferent 2 (NS) antagonism 0.02 (S) indifferent NRS4 0.25 (S) 0.125 (S) indifferent 0.06/1.19 (S) indifferent 2 (NS) indifferent >32 (NS) indifferent S. epidermidis R2270 0.25 (S) 0.125 (S) indifferent 0.125/2.38 (S) indifferent 0.5 (S) indifferent 0.02 (S) indifferent R2284 1 (NS) 0.13 (S) indifferent >4/76 (NS) indifferent 1 (NS) indifferent 0.02 (S) indifferent
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