77458 Search Results


sodium oxalate  (Chem Impex International)
95
Chem Impex International sodium oxalate
Sodium Oxalate, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sodium oxalate/product/Chem Impex International
Average 95 stars, based on 1 article reviews
sodium oxalate - by Bioz Stars, 2026-04
95/100 stars
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collagen type i alpha 1  (Novus Biologicals)
94
Novus Biologicals collagen type i alpha 1
FIGURE 4. Treatment of colitic mice with Smad7 antisense oligonucleotide reduces collagen deposition and fibrosis. A, Representative photomicro- graphs of colon sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I <t>alpha</t> 1 antibody (right panels), or relative isotype IgG (middle panels). B, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Data indicate mean ± SEM of 3 independent experiments in which 18 mice per group were analyzed.
Collagen Type I Alpha 1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/collagen type i alpha 1/product/Novus Biologicals
Average 94 stars, based on 1 article reviews
collagen type i alpha 1 - by Bioz Stars, 2026-04
94/100 stars
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collagen type i alpha 1 chain  (Novus Biologicals)
92
Novus Biologicals collagen type i alpha 1 chain
FIGURE 4. Treatment of colitic mice with Smad7 antisense oligonucleotide reduces collagen deposition and fibrosis. A, Representative photomicro- graphs of colon sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I <t>alpha</t> 1 antibody (right panels), or relative isotype IgG (middle panels). B, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Data indicate mean ± SEM of 3 independent experiments in which 18 mice per group were analyzed.
Collagen Type I Alpha 1 Chain, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/collagen type i alpha 1 chain/product/Novus Biologicals
Average 92 stars, based on 1 article reviews
collagen type i alpha 1 chain - by Bioz Stars, 2026-04
92/100 stars
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sgk1 grna (brdn0001147869) (plasmid #77458)  (Addgene inc)
N/A
Standard format: Plasmid sent in bacteria as agar stab
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FIGURE 4. Treatment of colitic mice with Smad7 antisense oligonucleotide reduces collagen deposition and fibrosis. A, Representative photomicro- graphs of colon sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I alpha 1 antibody (right panels), or relative isotype IgG (middle panels). B, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Data indicate mean ± SEM of 3 independent experiments in which 18 mice per group were analyzed.

Journal: Inflammatory bowel diseases

Article Title: Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice.

doi: 10.1093/ibd/izy062

Figure Lengend Snippet: FIGURE 4. Treatment of colitic mice with Smad7 antisense oligonucleotide reduces collagen deposition and fibrosis. A, Representative photomicro- graphs of colon sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I alpha 1 antibody (right panels), or relative isotype IgG (middle panels). B, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Data indicate mean ± SEM of 3 independent experiments in which 18 mice per group were analyzed.

Article Snippet: The slides were then incubated with a rabbit polyclonal antibody directed against collagen type I alpha 1 (final dilution 1:20 000; Novus biologicals, Littleton, CO, USA) or with a rabbit polyclonal Smad7 antibody (final dilution 1:300; Biorbyt, Cambridgeshire, UK) at room temperature for 30 minutes.

Techniques: Control, Staining

FIGURE 6. Smad7 antisense oligonucleotide reduces colonic fibrosis in mice receiving long-term treatment with TNBS. A, Representative immunob- lots showing Smad7 and ERK1/2 in proteins extracted from mice receiving rectal administration of TNBS for 12 weeks and given Smad7 antisense oligonucleotide (AS) or control (sense) oligonucleotide starting from week 9 until the end of the study (week 12). B, Representative photomicro- graphs of H&E-stained colon sections of mice treated as indicated above. C, Representative photomicrographs of colon sections taken from TNBS- treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I alpha 1 antibody (right panels), or relative isotype IgG (middle panels). D, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Each point represents the value of the fibrosis score in a single mouse, and the horizontal bar indicates the median value. E, Soluble collagen in colon samples was analyzed by Sircol assay. Data are shown as mean ±SD.

Journal: Inflammatory bowel diseases

Article Title: Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice.

doi: 10.1093/ibd/izy062

Figure Lengend Snippet: FIGURE 6. Smad7 antisense oligonucleotide reduces colonic fibrosis in mice receiving long-term treatment with TNBS. A, Representative immunob- lots showing Smad7 and ERK1/2 in proteins extracted from mice receiving rectal administration of TNBS for 12 weeks and given Smad7 antisense oligonucleotide (AS) or control (sense) oligonucleotide starting from week 9 until the end of the study (week 12). B, Representative photomicro- graphs of H&E-stained colon sections of mice treated as indicated above. C, Representative photomicrographs of colon sections taken from TNBS- treated mice given Smad7 AS or control (sense) oligonucleotide and stained with Masson’s trichrome (left panels), collagen type I alpha 1 antibody (right panels), or relative isotype IgG (middle panels). D, Fibrosis microscopic score of colonic sections taken from TNBS-treated mice given Smad7 AS or control (sense) oligonucleotide. Each point represents the value of the fibrosis score in a single mouse, and the horizontal bar indicates the median value. E, Soluble collagen in colon samples was analyzed by Sircol assay. Data are shown as mean ±SD.

Article Snippet: The slides were then incubated with a rabbit polyclonal antibody directed against collagen type I alpha 1 (final dilution 1:20 000; Novus biologicals, Littleton, CO, USA) or with a rabbit polyclonal Smad7 antibody (final dilution 1:300; Biorbyt, Cambridgeshire, UK) at room temperature for 30 minutes.

Techniques: Control, Staining

FIGURE 7. Smad7 AS oligonucleotide reduces DSS-induced colitis-driven colonic fibrosis. A, Representative immunoblots showing Smad7 and ERK1/2 in total proteins extracted from the colons of control mice, DSS-treated mice, and DSS-treated mice given Smad7 AS or control (sense) oligo- nucleotide. Right panel, Quantitative analysis of Smad7/ERK1/2 protein ratio in extracts of colon specimens measured by densitometry scanning of immunoblots. Values are expressed in arbitrary units (a.u.). Each point represents the value of the Smad7/ERK1/2 protein ratio in a single mouse, and the horizontal bar indicates the median value. B, Representative photomicrographs of colon sections taken from control and DSS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with collagen type I alpha 1 antibody (lower panels) or relative isotype IgG (upper panels).

Journal: Inflammatory bowel diseases

Article Title: Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice.

doi: 10.1093/ibd/izy062

Figure Lengend Snippet: FIGURE 7. Smad7 AS oligonucleotide reduces DSS-induced colitis-driven colonic fibrosis. A, Representative immunoblots showing Smad7 and ERK1/2 in total proteins extracted from the colons of control mice, DSS-treated mice, and DSS-treated mice given Smad7 AS or control (sense) oligo- nucleotide. Right panel, Quantitative analysis of Smad7/ERK1/2 protein ratio in extracts of colon specimens measured by densitometry scanning of immunoblots. Values are expressed in arbitrary units (a.u.). Each point represents the value of the Smad7/ERK1/2 protein ratio in a single mouse, and the horizontal bar indicates the median value. B, Representative photomicrographs of colon sections taken from control and DSS-treated mice given Smad7 AS or control (sense) oligonucleotide and stained with collagen type I alpha 1 antibody (lower panels) or relative isotype IgG (upper panels).

Article Snippet: The slides were then incubated with a rabbit polyclonal antibody directed against collagen type I alpha 1 (final dilution 1:20 000; Novus biologicals, Littleton, CO, USA) or with a rabbit polyclonal Smad7 antibody (final dilution 1:300; Biorbyt, Cambridgeshire, UK) at room temperature for 30 minutes.

Techniques: Western Blot, Control, Staining