Journal: Sensors and Actuators B: Chemical

Article Title: Phenotyping antibiotic resistance with single-cell resolution for the detection of heteroresistance

doi: 10.1016/j.snb.2018.05.047

Figure Lengend Snippet: Fig. 1. Scheme and optical images of the microfluidic process flow. The process consists of three main parts: (a) droplet generation and encapsulation of bac- teria with antibiotic, (b) pico-injection of alamarBlue into droplets, and (c) the detection of fluorescence from the drops.

Article Snippet: [28] We used ampicillin (Alfa Aesar) as the model antibiotic for Figs. 2–4, norfloxacin (Chem-Impex Int’l Inc.), kanamycin (bioWORLD), and tetracycline (Sigma-Aldrich) as model antibiotics for Fig. 5, and ampicillin, norfloxacin, and kanamycin as model antibiotics for Fig. 6.

Techniques: Encapsulation, Injection

Journal: Pharmaceutics

Article Title: Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

doi: 10.3390/pharmaceutics15071786

Figure Lengend Snippet: Normalized X-ray powder diffractogram ( left panel) and THz absorption spectra ( right panel) of ( A ) crystalline norfloxacin, ( B ) crystalline sucrose, ( C ) blank smartFilm tablet, ( D ) physical mixture tablet containing 20 w / w % sucrose and 10 w / w % norfloxacin, ( E ) granulated norfloxacin-loaded smartFilm tablet and ( F ) non-granulated norfloxacin-loaded smartFilm tablet. The horizontal lines mark the most prominent diffraction peaks (panels on the left, XRD) or the characteristic absorption features (panels on the right, THz TDS) of crystalline norfloxacin (dashed blue lines) and sucrose (dotted red line). For clarity, only one diffractogram/spectrum is shown per sample type.

Article Snippet: Norfloxacin (95%, CAS number: 70458-96-7) was acquired from abcr GmbH (Karlsruhe, Germany) and used as received.

Techniques:

Journal: Pharmaceutics

Article Title: Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

doi: 10.3390/pharmaceutics15071786

Figure Lengend Snippet: Fitted absorption coefficient (Abs. coeff.) of ( A ) physical mixture tablet containing 10 w / w % crystalline norfloxacin, ( B ) granulated norfloxacin-loaded smartFilm tablet, ( C ) non-granulated norfloxacin-loaded smartFilm tablet and ( D ) crystalline norfloxacin. The solid lines represent the original spectra, the black dotted lines the fitted background absorption and the dashed lines the fitted spectra. In ( A – C ) the spectral region around the most prominent absorption peak in the investigated range is shown and the shaded areas relate to the amount of crystalline norfloxacin in the samples. In ( D ) the shaded areas illustrate the fitted peaks. The grey box indicates the frequency region that was not considered for the analysis of the physical mixtures and smartFilm tablets. ( E ) Estimated crystalline (Est. cryst.) norfloxacin content in physical mixtures, granulated and non-granulated smartFilm tablets. The linear fit regarding the physical mixtures is shown as the grey dashed-dotted line. Inset: estimated crystalline norfloxacin content in granulated (red square) and non-granulated (blue circle) smartFilm tablets. The error bars represent the standard deviation of the assessed crystalline norfloxacin content of the three samples per sample type. Note that a closer look at the determined crystalline content of the granulated and non-granulated tablets shown in the inset in ( E ) reveals that the values clearly differ.

Article Snippet: Norfloxacin (95%, CAS number: 70458-96-7) was acquired from abcr GmbH (Karlsruhe, Germany) and used as received.

Techniques: Standard Deviation

Journal: Pharmaceutics

Article Title: Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

doi: 10.3390/pharmaceutics15071786

Figure Lengend Snippet: Extracted Gaussian peak properties for the individual absorption peaks of crystalline norfloxacin including their amplitude ( G ), frequency position ( v 0 ) and width (Δ v ).

Article Snippet: Norfloxacin (95%, CAS number: 70458-96-7) was acquired from abcr GmbH (Karlsruhe, Germany) and used as received.

Techniques:

Journal: Pharmaceutics

Article Title: Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

doi: 10.3390/pharmaceutics15071786

Figure Lengend Snippet: ( A ) Normalized (Norm.) X-ray powder diffractogram and ( B ) THz absorption coefficient (Abs. coeff.) of a physical mixture containing 2.5 w / w % norfloxacin. The dashed blue horizontal lines mark the position of the most prominent diffraction features ( A , XRD) or the characteristic absorption peaks ( B , THz TDS) of crystalline norfloxacin (see panels ( A ) in ).

Article Snippet: Norfloxacin (95%, CAS number: 70458-96-7) was acquired from abcr GmbH (Karlsruhe, Germany) and used as received.

Techniques: