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Image Search Results
Journal: Emerging Microbes & Infections
Article Title: Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis
doi: 10.1080/22221751.2024.2382235
Figure Lengend Snippet: Ferroptosis in human motor neurons after EV-A71 infection. A. Expression levels of FTL and FTH1 after infection in each population. B. Expression levels of FTL and FTH1 after infection in each population with high viral RNA load (High) and low viral RNA load (Low). C. Free irons within the cells were measured by Ferro-Orange. D. Number of cells that were positive for Ferro-Orange in the EV-A71-infected and mock-infected cultures. E. Ferro-Orange intensity in each cell at 6 h after EV-A71 or mock infection. n > 1900 cells from 3 cultures, Mann-Whitney Test, **** p < 0.0001. F. Lipid peroxidation measured by BODIPY C11 581/591. G. Number of cells displaying oxidized C11 in EV-A71-infected and mock cultures. H. Mean oxidized C11 intensity in each cell at 24 h after EV-A71 or mock infection. n > 2300 cells from 3 cultures, Mann-Whitney Test, **** p < 0.0001.
Article Snippet: The siRNAs used were: SCARB2 (Dharmacon, #012087), FTL (SCBT, sc-40577),
Techniques: Infection, Expressing, MANN-WHITNEY