37560 Search Results


amitriptyline  (Chem Impex International)
95
Chem Impex International amitriptyline
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Amitriptyline, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tail flick latencies  (UGO Basile S.R.L)
96
UGO Basile S.R.L tail flick latencies
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Tail Flick Latencies, supplied by UGO Basile S.R.L, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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plasmid plenti metgfp  (Addgene inc)
93
Addgene inc plasmid plenti metgfp
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Plasmid Plenti Metgfp, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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edta disodium salt dehydrate 37560  (Anachemia Chemicals)
90
Anachemia Chemicals edta disodium salt dehydrate 37560
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Edta Disodium Salt Dehydrate 37560, supplied by Anachemia Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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msc15w, sn 37560;  (Gigahertz-Optik)
90
Gigahertz-Optik msc15w, sn 37560;
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Msc15w, Sn 37560;, supplied by Gigahertz-Optik, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chemical co., 37560  (Kanto Chemical)
90
Kanto Chemical chemical co., 37560
Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and <t>amitriptyline</t> (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.
Chemical Co., 37560, supplied by Kanto Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and amitriptyline (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.

Journal: Cell Reports Methods

Article Title: Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array

doi: 10.1016/j.crmeth.2025.101051

Figure Lengend Snippet: Inhibitory effects of kinase inhibitors and atypical analgesics on hiPSC nociceptors The inhibitory impact of various kinase inhibitors as well as atypical serotonin-norepinephrine reuptake inhibitor (SNRI) and tricyclic antidepressant (TCA) analgesics on the activity of hiPSC nociceptors following a 28-day culture period is evaluated. (A)–(C) and (D)–(F) represent data obtained using dasatinib (a multiple tyrosine kinase inhibitor) and baricitinib (a JAK1/2 inhibitor), respectively. (G)–(I) and (J)–(L) represent data obtained using duloxetine (SNRI) and amitriptyline (TCA), respectively. For each inhibitor, the percentage of inhibition of neuronal activity at 37°C and 47°C is shown (A), (B), (D), (E), (G), (H), (J), and (K) and was calculated relative to 37°C or 42°C baseline, respectively. Additionally, the spike rate of hiPSC nociceptors was monitored for 10 min before and after treatment with the respective blocker (C), (F), (I), and (L) at 37°C to evaluate acute effects (6 wells for each concentration). Pilot studies were conducted to determine the effective concentration range. Data are presented as mean ± SEM (standard error of the mean). See also for statistical comparisons and for relevant gene expression for these targets.

Article Snippet: Amitriptyline , Chem-Impex , Cat#37560.

Techniques: Activity Assay, Inhibition, Concentration Assay, Gene Expression