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64 1 0 1 0 newman mssa  (ATCC)
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ATCC 64 1 0 1 0 newman mssa
MICs of SAL200 and SOC antibiotics against Staphylococcus aureus isolates
64 1 0 1 0 Newman Mssa, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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amp  (Chem Impex International)
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Chem Impex International amp
MICs of SAL200 and SOC antibiotics against Staphylococcus aureus isolates
Amp, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pgemtez kir2 1  (Addgene inc)
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Addgene inc pgemtez kir2 1
MICs of SAL200 and SOC antibiotics against Staphylococcus aureus isolates
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MICs of SAL200 and SOC antibiotics against Staphylococcus aureus isolates

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: MICs of SAL200 and SOC antibiotics against Staphylococcus aureus isolates

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques:

MICs for combination of SAL200 and nafcillin

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: MICs for combination of SAL200 and nafcillin

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques:

MICs for combination of SAL200 and vancomycin

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: MICs for combination of SAL200 and vancomycin

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques:

Time-kill curves for MRSA LAC (a) and MSSA Newman (b) treated with buffer and MICs and sub-MICs of either SAL200, SOC antibiotics, or combinations of SAL200 and SOC antibiotics. The curves were jittered vertically by adding random numbers within the range of −0.1 to 0.1 unit to the bacterial densities at times of 60, 120, 240, and 360 min after culture. Vanco, vancomycin; NAF, nafcillin; SAL, SAL200.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: Time-kill curves for MRSA LAC (a) and MSSA Newman (b) treated with buffer and MICs and sub-MICs of either SAL200, SOC antibiotics, or combinations of SAL200 and SOC antibiotics. The curves were jittered vertically by adding random numbers within the range of −0.1 to 0.1 unit to the bacterial densities at times of 60, 120, 240, and 360 min after culture. Vanco, vancomycin; NAF, nafcillin; SAL, SAL200.

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques:

Bacterial density in blood from MRSA LAC-infected mice at 1 h after treatment (a), blood from MSSA Newman-infected mice at 1 h after treatment (b), the spleen at 72 h after MRSA LAC infection (c), and the spleen at 72 h after MSSA Newman infection (d). As only 1 mouse in the negative-control group survived beyond 72 h after MSSA Newman infection, a direct comparison with the control group was not possible. For comparison, a hypothetical splenic bacterial density was presumed to exceed 7.5 log10 CFU/g in the dead mice.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: Bacterial density in blood from MRSA LAC-infected mice at 1 h after treatment (a), blood from MSSA Newman-infected mice at 1 h after treatment (b), the spleen at 72 h after MRSA LAC infection (c), and the spleen at 72 h after MSSA Newman infection (d). As only 1 mouse in the negative-control group survived beyond 72 h after MSSA Newman infection, a direct comparison with the control group was not possible. For comparison, a hypothetical splenic bacterial density was presumed to exceed 7.5 log10 CFU/g in the dead mice.

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques: Infection, Negative Control, Comparison, Control

Effect of SAL200 combined with SOC antibiotics on survival of Galleria mellonella larvae infected with MRSA LAC (a) and MSSA Newman (b). The survival lines were jittered to prevent overplotting. *, P < 0.01 for the tested antibiotic compared with the PBS-treated control; #, P values for the combination compared to SOC antibiotics (P = 0.153 for vancomycin-SAL200 versus vancomycin and P = 0.140 for cefazolin-SAL200 versus cefazolin).

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

doi: 10.1128/AAC.00731-18

Figure Lengend Snippet: Effect of SAL200 combined with SOC antibiotics on survival of Galleria mellonella larvae infected with MRSA LAC (a) and MSSA Newman (b). The survival lines were jittered to prevent overplotting. *, P < 0.01 for the tested antibiotic compared with the PBS-treated control; #, P values for the combination compared to SOC antibiotics (P = 0.153 for vancomycin-SAL200 versus vancomycin and P = 0.140 for cefazolin-SAL200 versus cefazolin).

Article Snippet: Synergy was also seen for the combination of SAL200 and vancomycin in the S. aureus strains ATCC B1707, Newman, and ATCC 29213. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain a Median (range) MIC (μg/ml) SAL200 Nafcillin Vancomycin ATCC 33591 (MRSA) 1.6 (0.8–1.6) >64 (>64) 1.5 (1.0–2.0) ATCC B1707 (MRSA) 1.2 (0.8–1.6) 32 (32) 1.5 (1.0–2.0) LAC (MRSA) 1.6 (1.6) 32 (32–64) 1.0 (1.0) Newman (MSSA) 0.8 (0.8–1.6) 0.5 (0.5) 1.0 (1.0–2.0) ATCC 29213 (MSSA) 1.2 (0.8–1.6) 0.5 (0.5) 1.0 (1.0) Open in a separate window a ATCC, American Type Culture Collection; MRSA, methicillin-resistant Staphylococcus aureus ; MSSA, methicillin-susceptible S. aureus .

Techniques: Infection, Control