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Image Search Results
Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: Increased KHDC4 levels are associated with the development of advanced prostate cancer. ( A ) The volcano plot illustrates an elevation in KHDC4 levels among patients in the late stage of TCGA-PRAD. ( B ) The associated expression intensity of KHDC4 in patients from TCGA-PRAD. ( C ) The correlated expression levels of KHDC members in patients from TCGA-PRAD. ( D ) The correlated expression intensity of KHDC4 in normal solid tissue and primary prostate tumor. ( E ) The difference in the level of KHDC4 between late-stage or lymph node metastasis in TCGA-PRAD patients. ( F ) The correlation of KHDC4 levels with advanced prostate cancer across different sources of prostate cohorts ( GSE21032 , GSE35988 , GSE6919 ). ( G ) The correlation of KHDC4 levels with prognosis values in cancer across different cohort sources. ( H ) KHDC 4 expression levels across diverse racial backgrounds. ( I ) Analysis of single-cell sequencing profiles ( GSE176031 ) reveals the relative expression intensity of KHDC4 across different cell types. ( J ) The prognostic impact of KHDC4 on overall survival and disease-free survival rates in prostate cancer.
Article Snippet:
Techniques: Expressing, Sequencing
Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: KHDC4-mediated adverse prognosis outcomes in prostate cancer are linked to the involvement of TRAF2. ( A ) A Venn diagram analysis was conducted to gather molecules that are positively or negatively correlated with KHDC4 in TCGA-PRAD datasets, including Cell 2015, Firehose Legacy, and PanCancer Atlas. ( B ) The graphical abstract illustrates the potential biological roles influenced by KHDC4 in prostate cancer. ( C ) The canonical pathways influenced by KHDC4-related molecules. ( D ) Molecular connections associated with KHDC4 regulation in prostate cancer. ( E ) Volcano plot depicts elevated TRAF2 levels in late-stage TCGA-PRAD patients. ( F ) The correlation between KHDC4 and TRAF2 in TCGA-PRAD patients. ( G ) The correlation between KHDC4 and TRAF2 in CCLE prostate cancer cell lines. ( H ) The related expression intensity of TRAF2 in TCGA-PRAD patients. ( I ) The difference in the level of TRAF2 between late-stage or lymph node metastasis in TCGA-PRAD patients. ( J ) The correlation of TRAF2 levels with advanced prostate cancer in different sources of prostate cohorts ( GSE21032 , GSE35988 , GSE6919 ). ( K ) Analysis of single-cell sequencing profile ( GSE176031 ) to examine the relative expression levels of KHDC4 and TRAF2 across different cell types. ( L ) The impact of TRAF2 expression levels on overall survival and disease-free survival rates in prostate cancer.
Article Snippet:
Techniques: Expressing, Sequencing
Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: The correlation between KHDC4 and TRAF2 at a pathological level contributes to an advanced Gleason score. ( A ) The correlation between KHDC4 and TRAF2 in distinct pathologic stages of TCGA-PRAD data. ( B ) The correlation between KHDC4 and TRAF2 in different pathologic lymph node metastasis stages of TCGA-PRAD data. ( C ) The related levels of KHDC4, TRAF2, and KLK3 in TCGA-PRAD data across various Gleason scores. ( D ) The correlation of KHDC4, TRAF2, and KLK3 with Gleason scores in TCGA-PRAD data.
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Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: Shared gene ontology between TRAF2 and KHDC4 is associated with adverse prognosis outcomes. ( A ) A Venn diagram analysis collecting molecules positively or negatively correlated to TRAF2 in TCGA-PRAD datasets (Cell 2015, Firehose Legacy, and PanCancer Atlas). ( B ) Graphical abstract illustrating the potential biological roles influenced by TRAF2 in prostate cancer. ( C ) Canonical pathways affected by TRAF2-related molecules. ( D ) Molecular links to TRAF2 regulations in prostate cancer. ( E ) The correlation of KHDC4 and TRAF2 individually with Progression-Free Interval (PFI) and Disease-Free Interval (DFI) in TCGA-PRAD. ( F ) The correlation of Progression-Free Interval (PFI) and Disease-Free Interval (DFI) in TCGA-PRAD with the combined distribution of KHDC4 and TRAF2.
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Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: E2F4 is positioned as an upstream controller in the regulatory cascade of KHDC4 and TRAF2. ( A ) Promoter assays outlining potential E2F4 binding sequences in the promoter sequences of TRAF2 and KHDC4. ( B ) The correlation of E2F4 with KHDC4 or TRAF2 in TCGA-PRAD. ( C ) The prognosis values of E2F4 on overall survival or disease-free survival rate in prostate cancer. ( D ) A Venn diagram analysis collecting molecules positively correlated to KHDC4 and TRAF2 in TCGA-PRAD datasets (Cell 2015, Firehose Legacy, and PanCancer Atlas). ( E ) Downstream effectors co-regulated by KHDC4 and TRAF2. ( F ) The correlation of downstream effectors of KHDC4 and TRAF2 with E2F4 in TCGA-PRAD.
Article Snippet:
Techniques: Binding Assay
Journal: Aging (Albany NY)
Article Title: Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
doi: 10.18632/aging.206273
Figure Lengend Snippet: The diagram illustrates how E2F4 potentially functions as a transcription factor to activate the KHDC4-TRAF2 axis, leading to the generation of downstream effectors and promoting the development of advanced prostate cancer. The molecules identified in this model can be employed as valuable prognosis biomarkers or signatures for predicting potential outcomes in prostate cancer patients.
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