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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.
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Image Search Results


UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.

Journal: Frontiers in Pharmacology

Article Title: Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

doi: 10.3389/fphar.2021.761814

Figure Lengend Snippet: UGT-selective metabolic pathways inhibition mediated by ticagrelor and ticagrelor-O-glucuronides.

Article Snippet: Reference standard of ticagrelor (purity 95.0%), 7-Ethyl-10-hydroxy-camptothecin (SN-38) glucuronide (purity 97%), chenodeoxycholic acid 24-acyl-β-D-glucuronide (purity 96%), N-Acetyl serotonin β-D-glucuronide (purity 97%), mycophenolic acid β-D-glucuronide (purity 96%), 3′-azide-3′-deoxythymidine β-D-glucuronide sodium salt (purity 97%), bupropion (purity 98%), hydroxy bupropion (purity >98%), amodiaquine (purity >95%), N-Desethyl amodiaquine hydrochloride (purity >95%), 4′-hydroxylation diclofenac (purity >95%), S-mephenytoin, S - 4 - hydroxy mephenytoin (purity >98%), dextromethorphan (purity >95%), dextrorphan tartrate salt (purity >98%), and furafylline (purity >95%, internal standard) were purchased from Toronto Research Chemicals (Toronto, ON, Canada).

Techniques: Inhibition

Effects of ticagrelor (A) and ticagrelor-O-Glu (B) on the activities of human UGT enzymes. SN-38, chenodeoxycholic acid, trifluoperazine, N-Acetyl serotonin, mycophenolic acid, 3′-azide-3′-deoxythymidine were used as the probe substrates for UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9 and UGT2B7, respectively. Each bar represents the mean ± S.D. of triple incubations. *, p < 0.05; **, p < 0.01; ***, p < 0.001, ****, p < 0.0001. Each bar represents the mean ± S.D. of triple incubations.

Journal: Frontiers in Pharmacology

Article Title: Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

doi: 10.3389/fphar.2021.761814

Figure Lengend Snippet: Effects of ticagrelor (A) and ticagrelor-O-Glu (B) on the activities of human UGT enzymes. SN-38, chenodeoxycholic acid, trifluoperazine, N-Acetyl serotonin, mycophenolic acid, 3′-azide-3′-deoxythymidine were used as the probe substrates for UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9 and UGT2B7, respectively. Each bar represents the mean ± S.D. of triple incubations. *, p < 0.05; **, p < 0.01; ***, p < 0.001, ****, p < 0.0001. Each bar represents the mean ± S.D. of triple incubations.

Article Snippet: Reference standard of ticagrelor (purity 95.0%), 7-Ethyl-10-hydroxy-camptothecin (SN-38) glucuronide (purity 97%), chenodeoxycholic acid 24-acyl-β-D-glucuronide (purity 96%), N-Acetyl serotonin β-D-glucuronide (purity 97%), mycophenolic acid β-D-glucuronide (purity 96%), 3′-azide-3′-deoxythymidine β-D-glucuronide sodium salt (purity 97%), bupropion (purity 98%), hydroxy bupropion (purity >98%), amodiaquine (purity >95%), N-Desethyl amodiaquine hydrochloride (purity >95%), 4′-hydroxylation diclofenac (purity >95%), S-mephenytoin, S - 4 - hydroxy mephenytoin (purity >98%), dextromethorphan (purity >95%), dextrorphan tartrate salt (purity >98%), and furafylline (purity >95%, internal standard) were purchased from Toronto Research Chemicals (Toronto, ON, Canada).

Techniques:

Journal: Cell Reports Medicine

Article Title: Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

doi: 10.1016/j.xcrm.2021.100288

Figure Lengend Snippet:

Article Snippet: SARS Cov-2 S1 protein , ACROBiosystems , #S1N-C52H3-100ug.

Techniques: Virus, Plasmid Preparation, Recombinant, Over Expression, Mass Spectrometry, Software