19950 Search Results


hmds iso  (ATCC)
93
ATCC hmds iso
Hmds Iso, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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primary antibodies against gnrhr  (Proteintech)
94
Proteintech primary antibodies against gnrhr
Figure 4 Effect of PSE-NPs on the <t>GnRhR</t> signaling pathway and expression of meiosis-related proteins SCP3 of GC-1 cells damaged by adriamycin: (A–E) Protein expression of GnRhR, GNAS, p-CREB and SCP3 in GC-1 cells, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. ##P < 0.01 vs the Model group. &&P < 0.01 vs the PSE group. Abbreviations: CON, control group underwent standard culture; M, model group; PLGA, empty nanoparticles; PSE, 0.5μM pseudoephedrine; PSE-PLGA, 0.25 μM pseudoephedrine-loaded PLGA nanoparticles; GnRhR, gonadotropin-releasing hormone receptor; CREB, cyclic adenosine monophosphate (cAMP)-response element binding protein; GNAS, <t>guanine</t> <t>nucleotide</t> binding protein; SCP3, small C-terminal domain phosphatase 3.
Primary Antibodies Against Gnrhr, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phage 113  (ATCC)
96
ATCC phage 113
Figure 4 Effect of PSE-NPs on the <t>GnRhR</t> signaling pathway and expression of meiosis-related proteins SCP3 of GC-1 cells damaged by adriamycin: (A–E) Protein expression of GnRhR, GNAS, p-CREB and SCP3 in GC-1 cells, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. ##P < 0.01 vs the Model group. &&P < 0.01 vs the PSE group. Abbreviations: CON, control group underwent standard culture; M, model group; PLGA, empty nanoparticles; PSE, 0.5μM pseudoephedrine; PSE-PLGA, 0.25 μM pseudoephedrine-loaded PLGA nanoparticles; GnRhR, gonadotropin-releasing hormone receptor; CREB, cyclic adenosine monophosphate (cAMP)-response element binding protein; GNAS, <t>guanine</t> <t>nucleotide</t> binding protein; SCP3, small C-terminal domain phosphatase 3.
Phage 113, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
phage 113 - by Bioz Stars, 2026-02
96/100 stars
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Image Search Results


Figure 4 Effect of PSE-NPs on the GnRhR signaling pathway and expression of meiosis-related proteins SCP3 of GC-1 cells damaged by adriamycin: (A–E) Protein expression of GnRhR, GNAS, p-CREB and SCP3 in GC-1 cells, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. ##P < 0.01 vs the Model group. &&P < 0.01 vs the PSE group. Abbreviations: CON, control group underwent standard culture; M, model group; PLGA, empty nanoparticles; PSE, 0.5μM pseudoephedrine; PSE-PLGA, 0.25 μM pseudoephedrine-loaded PLGA nanoparticles; GnRhR, gonadotropin-releasing hormone receptor; CREB, cyclic adenosine monophosphate (cAMP)-response element binding protein; GNAS, guanine nucleotide binding protein; SCP3, small C-terminal domain phosphatase 3.

Journal: International Journal of Nanomedicine

Article Title: Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway

doi: 10.2147/ijn.s348673

Figure Lengend Snippet: Figure 4 Effect of PSE-NPs on the GnRhR signaling pathway and expression of meiosis-related proteins SCP3 of GC-1 cells damaged by adriamycin: (A–E) Protein expression of GnRhR, GNAS, p-CREB and SCP3 in GC-1 cells, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. ##P < 0.01 vs the Model group. &&P < 0.01 vs the PSE group. Abbreviations: CON, control group underwent standard culture; M, model group; PLGA, empty nanoparticles; PSE, 0.5μM pseudoephedrine; PSE-PLGA, 0.25 μM pseudoephedrine-loaded PLGA nanoparticles; GnRhR, gonadotropin-releasing hormone receptor; CREB, cyclic adenosine monophosphate (cAMP)-response element binding protein; GNAS, guanine nucleotide binding protein; SCP3, small C-terminal domain phosphatase 3.

Article Snippet: After membranes were blocked with 5% BSA in buffer for 2 h, primary antibodies against GnRhR (1:500 dilution; 19950-1-AP; Proteintech), guanine nucleotide binding protein (GNAS; 1:1000; ab283266; Abcam), protein kinase A (PKA; 1:1000; 12232-1-AP, Proteintech), phosphorylated-cyclic adenosine monophosphate (cAMP)-response element binding protein (p-CREB; 1:1000; 9198; Cell Signaling Technology, Danvers, MA, USA), CREB (1:1000; 12208-1-AP; Proteintech), SCP3 (small C-terminal domain phosphatase 3, 1:1000; 23024- 1-AP; Proteintech), REC8 meiotic recombination protein (REC8; 1:1000; ab192241; Proteintech), cAMP (Cyclic Adenosine monophosphate, 1:1000; ab134901; Abcam), Caspase 3 (1:1000; ab32351, Abcam), Bax (BCL2-Associated X, 1:1000; 60267-1-Ig, Proteintech), Bcl-2 (B cell lymphoma-2, 1:1000; 60178-1-Ig, Proteintech) or β-Actin (1:5000; 66009-1-Ig; Proteintech) were added and incubation allowed to occur overnight at 4°C.

Techniques: Expressing, Control, Binding Assay

Figure 7 Effects of PSE-NPs on sex-hormone levels, GnRh signaling pathway-related proteins in testes, and indices of meiosis in mice: (A) Levels of GnRh, LH and testosterone in the serum of mice in each group. (B) mRNA expression of GnRh signaling pathway-related proteins and meiosis-associated genes in the testicular tissue of mice in each group was measured by RT-qPCR. (C) Protein expression of GnRh signaling pathway and meiosis-associated proteins in the testicular tissue of mice in each group was measured by western blotting. (D) The protein expression of GnRhR and SCP3 in the testicular tissue of mice in each group was measured by Immunofluorescence, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. #P < 0.05 and ##P < 0.01 vs the Model group. &P < 0.05 and &&P < 0.01 vs the PSE group. Abbreviations: CON, Control group; M, Model group with 30 mg/kg adriamycin, i.p.; PSE, 1.4 mg/kg PSE, i.v.; PLGA, 53.8 mg/kg PLGAs, i.v.; PSE-PLGA, 53.8 mg/kg PSE- PLGAs, i.v.; GnRh, gonadotropin-releasing hormone; LH, luteinizing hormone; GnRHR, gonadotropin-releasing hormone receptor; LHR, luteinising hormone receptor; AR, androgen receptor; GNAS, guanine nucleotide-binding proteins; ADCY1, adenylate cyclase type 1; PKA, protein kinase A; DAZ1, deleted in azoospermia protein 1; DDX4, Dead box polypeptide 4; STAR, StAR-related lipid transfer protein 8; SCP3, synaptonemal complex protein 3; REC8, meiotic recombination protein; SMC1B, structural maintenance of chromosomes protein 1B; Miwi, murine piwi gene; cAMP, Cyclic Adenosine monophosphate.

Journal: International Journal of Nanomedicine

Article Title: Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway

doi: 10.2147/ijn.s348673

Figure Lengend Snippet: Figure 7 Effects of PSE-NPs on sex-hormone levels, GnRh signaling pathway-related proteins in testes, and indices of meiosis in mice: (A) Levels of GnRh, LH and testosterone in the serum of mice in each group. (B) mRNA expression of GnRh signaling pathway-related proteins and meiosis-associated genes in the testicular tissue of mice in each group was measured by RT-qPCR. (C) Protein expression of GnRh signaling pathway and meiosis-associated proteins in the testicular tissue of mice in each group was measured by western blotting. (D) The protein expression of GnRhR and SCP3 in the testicular tissue of mice in each group was measured by Immunofluorescence, scale bar 50 μm. Notes: Data are the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 vs the CON group. #P < 0.05 and ##P < 0.01 vs the Model group. &P < 0.05 and &&P < 0.01 vs the PSE group. Abbreviations: CON, Control group; M, Model group with 30 mg/kg adriamycin, i.p.; PSE, 1.4 mg/kg PSE, i.v.; PLGA, 53.8 mg/kg PLGAs, i.v.; PSE-PLGA, 53.8 mg/kg PSE- PLGAs, i.v.; GnRh, gonadotropin-releasing hormone; LH, luteinizing hormone; GnRHR, gonadotropin-releasing hormone receptor; LHR, luteinising hormone receptor; AR, androgen receptor; GNAS, guanine nucleotide-binding proteins; ADCY1, adenylate cyclase type 1; PKA, protein kinase A; DAZ1, deleted in azoospermia protein 1; DDX4, Dead box polypeptide 4; STAR, StAR-related lipid transfer protein 8; SCP3, synaptonemal complex protein 3; REC8, meiotic recombination protein; SMC1B, structural maintenance of chromosomes protein 1B; Miwi, murine piwi gene; cAMP, Cyclic Adenosine monophosphate.

Article Snippet: After membranes were blocked with 5% BSA in buffer for 2 h, primary antibodies against GnRhR (1:500 dilution; 19950-1-AP; Proteintech), guanine nucleotide binding protein (GNAS; 1:1000; ab283266; Abcam), protein kinase A (PKA; 1:1000; 12232-1-AP, Proteintech), phosphorylated-cyclic adenosine monophosphate (cAMP)-response element binding protein (p-CREB; 1:1000; 9198; Cell Signaling Technology, Danvers, MA, USA), CREB (1:1000; 12208-1-AP; Proteintech), SCP3 (small C-terminal domain phosphatase 3, 1:1000; 23024- 1-AP; Proteintech), REC8 meiotic recombination protein (REC8; 1:1000; ab192241; Proteintech), cAMP (Cyclic Adenosine monophosphate, 1:1000; ab134901; Abcam), Caspase 3 (1:1000; ab32351, Abcam), Bax (BCL2-Associated X, 1:1000; 60267-1-Ig, Proteintech), Bcl-2 (B cell lymphoma-2, 1:1000; 60178-1-Ig, Proteintech) or β-Actin (1:5000; 66009-1-Ig; Proteintech) were added and incubation allowed to occur overnight at 4°C.

Techniques: Expressing, Quantitative RT-PCR, Western Blot, Immunofluorescence, Control, Binding Assay