1928 platform Search Results


1928 platform  (1928 Diagnostics)
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1928 Diagnostics 1928 platform
Overview of the bacterial isolates in the study. During a prospective observational study of community-onset severe sepsis and septic shock in adults conducted at Skaraborg Hospital, Sweden Ljungstrom approximately 1,800 bacterial isolates were recovered. Definite species identification of the collected isolates was performed by MALDI-TOF MS, identifying 272 bacterial isolates as S. aureus. Five isolates could not be recovered after freezing. In all, 267 isolates were prepared for DNA extraction and WGS. The output FASTQ pair-ended (PE) files for three of the isolates were excluded from the dataset after quality control of the raw data and the remaining 264 S. aureus were used as input into <t>the</t> <t>bioinformatic</t> analysis in the in-house pipeline and <t>1928</t> platform. During the benchmarking of species identification (step 1) nine FASTQ files did not pass the quality control levels in the 1928 platform. Only when benchmarking species identification, the depth/coverage was lowered to 11-29X. During the benchmarking of antibiotic sensitivity, virulence genes and ST (step 2) output from 255 isolates identified as S. aureus both phenotypically and genotypically were included
1928 Platform, supplied by 1928 Diagnostics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1928 platform - by Bioz Stars, 2026-03
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Overview of the bacterial isolates in the study. During a prospective observational study of community-onset severe sepsis and septic shock in adults conducted at Skaraborg Hospital, Sweden Ljungstrom approximately 1,800 bacterial isolates were recovered. Definite species identification of the collected isolates was performed by MALDI-TOF MS, identifying 272 bacterial isolates as S. aureus. Five isolates could not be recovered after freezing. In all, 267 isolates were prepared for DNA extraction and WGS. The output FASTQ pair-ended (PE) files for three of the isolates were excluded from the dataset after quality control of the raw data and the remaining 264 S. aureus were used as input into the bioinformatic analysis in the in-house pipeline and 1928 platform. During the benchmarking of species identification (step 1) nine FASTQ files did not pass the quality control levels in the 1928 platform. Only when benchmarking species identification, the depth/coverage was lowered to 11-29X. During the benchmarking of antibiotic sensitivity, virulence genes and ST (step 2) output from 255 isolates identified as S. aureus both phenotypically and genotypically were included

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Overview of the bacterial isolates in the study. During a prospective observational study of community-onset severe sepsis and septic shock in adults conducted at Skaraborg Hospital, Sweden Ljungstrom approximately 1,800 bacterial isolates were recovered. Definite species identification of the collected isolates was performed by MALDI-TOF MS, identifying 272 bacterial isolates as S. aureus. Five isolates could not be recovered after freezing. In all, 267 isolates were prepared for DNA extraction and WGS. The output FASTQ pair-ended (PE) files for three of the isolates were excluded from the dataset after quality control of the raw data and the remaining 264 S. aureus were used as input into the bioinformatic analysis in the in-house pipeline and 1928 platform. During the benchmarking of species identification (step 1) nine FASTQ files did not pass the quality control levels in the 1928 platform. Only when benchmarking species identification, the depth/coverage was lowered to 11-29X. During the benchmarking of antibiotic sensitivity, virulence genes and ST (step 2) output from 255 isolates identified as S. aureus both phenotypically and genotypically were included

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques: DNA Extraction

Genes and antibiotics assessed for each analysis in the 1928 platform accessed online June-July 2019

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Genes and antibiotics assessed for each analysis in the 1928 platform accessed online June-July 2019

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques:

Analyses used during the benchmarking

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Analyses used during the benchmarking

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques: Diffusion-based Assay, Sequencing

Antibiotic groups included in the benchmarking

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Antibiotic groups included in the benchmarking

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques: Diffusion-based Assay

Predicted genotypic AST results from the 1928 platform and the in-house pipeline compared to phenotypic AST

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Predicted genotypic AST results from the 1928 platform and the in-house pipeline compared to phenotypic AST

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques:

Output from 1928 and INH where genotypic prediction of antibiotic susceptibility test showed VME (bold) or ME (underlined)

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Output from 1928 and INH where genotypic prediction of antibiotic susceptibility test showed VME (bold) or ME (underlined)

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques: Diffusion-based Assay

Predicted presence (P) or absence (A) of certain virulence genes among 255 S. aureus isolates

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Predicted presence (P) or absence (A) of certain virulence genes among 255 S. aureus isolates

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques:

Extended genotypic prediction of the SCCmec type by 1928 platform among the 255 isolates

Journal: BMC Infectious Diseases

Article Title: Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis

doi: 10.1186/s12879-022-07977-0

Figure Lengend Snippet: Extended genotypic prediction of the SCCmec type by 1928 platform among the 255 isolates

Article Snippet: To comply with the aforementioned points the commercial cloud-based platform, 1928 platform (1928 Diagnostics, Gothenburg, Sweden) was benchmarked against an in-house developed bioinformatic pipeline (INH) as well as to reference methods in the clinical laboratory.

Techniques: