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Chem Impex International
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NEN Life Science
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HARTMANN ANALYTIC
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Image Search Results
Journal: The Journal of Clinical Investigation
Article Title: Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation
doi: 10.1172/JCI96221
Figure Lengend Snippet: (A) Western blots of long bones from 8-week-old Prx1-Cre Notch2fl/fl (PN2) mice and Notch2fl/fl (N2) littermates. Each lane is for a separate mouse. (B) Glucose consumption and lactate production in N2 and PN2 BMSCs with or without Jagged1 treatment for 48 hours. n = 3. (C–I) Analyses of 7-week-old N2 or PN2 mice that received 3PO or DMSO for 4 weeks starting at 3 weeks of age, including body weight (C), blood glucose (D), 14C-2DG uptake in bone (E), μCT images (F), μCT quantification (G), and dynamic histomorphometry (H) of trabecular bone in the proximal tibia, as well as serum CTX-I levels (I). n = 3. *P < 0.05, by 2-way ANOVA followed by Bonferroni’s post hoc test (C–E, H, and I) or 2-tailed Student’s t test (B and G). BV, bone volume; DPM, disintegrations per minute; TV, total volume.
Article Snippet: The mice were rested for 30 minutes before being injected i.p. with 14
Techniques: Western Blot