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Image Search Results
Journal: bioRxiv
Article Title: A spontaneous mutation in ADIPOR1 causes retinal degeneration in mice
doi: 10.1101/2024.06.06.597783
Figure Lengend Snippet: Abnormal levels of Rbp3 mRNA and altered spatial distribution of RBP3 protein. ( A ) Rbp3 mRNA is significantly upregulated in postnatal day (PD) 15 AdipoR1 −/− mice (KO) by RNAseq compared to AdipoR1 +/− (HET) and AdipoR1 +/+ (WT). p < 0.0001. Another interphotoreceptor matrix gene, Impg2 , is similar among the genotypes. p = 0.4614. ( C ) RBP3 (aka IRBP) protein in PD30 AdipoR1 +/+ is observed in two bands, one in the inner segments (IS) and the other at the tip of the OS, bordered by the outer nuclear layer (ONL) and (RPE). ( D ) In contrast, RBP3 is broadly distributed in the is and os region in Adipor1 −/− mice ( n = 3 per genotype). Scale bar is 10 μm for C and D.
Article Snippet: The primary
Techniques: