111-021 Search Results


purification usp7 full length  (Addgene inc)
90
Addgene inc purification usp7 full length
A) Structure-guided optimization of 1 led to <t>USP7</t> inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.
Purification Usp7 Full Length, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/111-021/PF3D7_0107300-COMP-blac-flag-his+(Plasmid+%23111021)/pmc05749250-578-4-18
Average 90 stars, based on 1 article reviews
purification usp7 full length - by Bioz Stars, 2026-09
90/100 stars
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asp4058  (MedChemExpress)
90
MedChemExpress asp4058
A) Structure-guided optimization of 1 led to <t>USP7</t> inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.
Asp4058, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/111-021/ASP-4058/pm32523984-231-2-7
Average 90 stars, based on 1 article reviews
asp4058 - by Bioz Stars, 2026-09
90/100 stars
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enzymatic assay  (Biothema AB)
93
Biothema AB enzymatic assay
A) Structure-guided optimization of 1 led to <t>USP7</t> inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.
Enzymatic Assay, supplied by Biothema AB, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/111-021/Kinase+RR+Kit/pm29456792__ml7b00374_si_001-282-18-27
Average 93 stars, based on 1 article reviews
enzymatic assay - by Bioz Stars, 2026-09
93/100 stars
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il21, human  (Gold Biotechnology Inc)
94
Gold Biotechnology Inc il21, human
A) Structure-guided optimization of 1 led to <t>USP7</t> inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.
Il21, Human, supplied by Gold Biotechnology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/111-021/IL21%2C+Human/custom%401110-21%4010%2E1101%2F2021%2E11%2E04%2E467302
Average 94 stars, based on 1 article reviews
il21, human - by Bioz Stars, 2026-09
94/100 stars
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Image Search Results


A) Structure-guided optimization of 1 led to USP7 inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.

Journal: Cell chemical biology

Article Title: Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

doi: 10.1016/j.chembiol.2017.09.003

Figure Lengend Snippet: A) Structure-guided optimization of 1 led to USP7 inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active.

Article Snippet: USP7 cloning, expression, and purification USP7 full length (amino acids 1-1102) and catalytic domain (208-560) were amplified using Addgene plasmid #16655( Cummins and Vogelstein, 2004 ) as a template and primers listed in Table S4 and cloned into pET28PP and pET28aLIC, respectively, using InFusion HD EcoDry Cloning Kit (Takara Bio Cat# 121416).

Techniques:

A) Ribbon diagram of USP7 with XL188.

Journal: Cell chemical biology

Article Title: Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

doi: 10.1016/j.chembiol.2017.09.003

Figure Lengend Snippet: A) Ribbon diagram of USP7 with XL188.

Article Snippet: USP7 cloning, expression, and purification USP7 full length (amino acids 1-1102) and catalytic domain (208-560) were amplified using Addgene plasmid #16655( Cummins and Vogelstein, 2004 ) as a template and primers listed in Table S4 and cloned into pET28PP and pET28aLIC, respectively, using InFusion HD EcoDry Cloning Kit (Takara Bio Cat# 121416).

Techniques:

A) Detailed ligand interaction diagram of XL188 with USP7. Residues for which >80% of other USPs contain an amino acid belonging to the same class are boxed red.

Journal: Cell chemical biology

Article Title: Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

doi: 10.1016/j.chembiol.2017.09.003

Figure Lengend Snippet: A) Detailed ligand interaction diagram of XL188 with USP7. Residues for which >80% of other USPs contain an amino acid belonging to the same class are boxed red.

Article Snippet: USP7 cloning, expression, and purification USP7 full length (amino acids 1-1102) and catalytic domain (208-560) were amplified using Addgene plasmid #16655( Cummins and Vogelstein, 2004 ) as a template and primers listed in Table S4 and cloned into pET28PP and pET28aLIC, respectively, using InFusion HD EcoDry Cloning Kit (Takara Bio Cat# 121416).

Techniques:

A–B) Structures, USP7 inhibitory activity and mouse liver microsome (MLM) stability of synthesized compounds.

Journal: Cell chemical biology

Article Title: Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

doi: 10.1016/j.chembiol.2017.09.003

Figure Lengend Snippet: A–B) Structures, USP7 inhibitory activity and mouse liver microsome (MLM) stability of synthesized compounds.

Article Snippet: USP7 cloning, expression, and purification USP7 full length (amino acids 1-1102) and catalytic domain (208-560) were amplified using Addgene plasmid #16655( Cummins and Vogelstein, 2004 ) as a template and primers listed in Table S4 and cloned into pET28PP and pET28aLIC, respectively, using InFusion HD EcoDry Cloning Kit (Takara Bio Cat# 121416).

Techniques: Activity Assay, Synthesized