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Image Search Results
Journal: Cell systems
Article Title: Identification of Nascent Memory CD8 T Cells and Modeling of Their Ontogeny.
doi: 10.1016/j.cels.2017.01.014
Figure Lengend Snippet: Figure 6. Predictive Simulations of Memory CD8 T Cell Counts (A–E) Mice were immunized by intranasal infection with vaccinia and recipients were bled at the indicated time points. Endogenous B8R-specific CD8 T cell responders were analyzed by flow cytometry for CD44, Mki67, and Bcl2 co-expression to calculate absolute numbers of total (blue, left-hand) and memory (purple, right-hand) cells (mean ± SD). The parameter values of the NELM model were estimated by fitting experimental data from: (A) D4–D7; (B) D4–D8; (C) D4–D13; (D) D4–D15; or (E) D6, D8, and D13; and cell dynamics were simulated (plain curves). Overlaid dashed curves correspond to the simulations obtained using all D4–D28 experimental data to estimate parameter values of the NELM model. Experimental time points used for fitting are inserted in graphs, displayed in black and highlighted by a shaded background. See also Figure S6.
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Techniques: Infection, Cytometry, Expressing