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Image Search Results
Journal: PLoS ONE
Article Title: BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway
doi: 10.1371/journal.pone.0148133
Figure Lengend Snippet: (A) Structural formula of 5-HT and BJ-1108. (B) After incubation with 5-HT for 3 days, the newly formed blood vessel branches on the 13-day-old chick CAM were counted. Data represent the mean ± S.E.M. of at least seven chick embryos. * P <0.05, compared with the untreated control group, (C) HUVECs in Matrigel-coated plates were treated with 5-HT for 14 h, and digital images were then taken under the microscope. (D) Migration pattern of HUVECs after treatment with VEGF or 5-HT for 5 h. The bar graph represents the mean ± S.E.M. of at least three independent experiments. * P <0.05, compared with the untreated control group. (E) Tube formation of HUVECs treated with 5-HT for 14 h in the absence or presence of 0.1 μM cyanopindolol (CYPD), Cinanserin (CISN), or SB269970 was quantitated by measuring tube length on the digital images. The bar graph represents the mean ± S.E.M. of at least three independent experiments. * P <0.05, compared with the untreated control group. # P <0.05 compared with the 5-HT-stimulated group.
Article Snippet: Gallein, AZM-475271, Cyanopindolol hemifumarate,
Techniques: Incubation, Control, Microscopy, Migration