00243 Search Results


l nio  (Biotium)
90
Biotium l nio
L Nio, supplied by Biotium, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/00243/L-NIO/pm19389198-102-11-12
Average 90 stars, based on 1 article reviews
l nio - by Bioz Stars, 2026-11
90/100 stars
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p propargyloxyl l phenylalanine  (Chem Impex International)
95
Chem Impex International p propargyloxyl l phenylalanine
P Propargyloxyl L Phenylalanine, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/00243/L-Phenylalanine/pm37377426__bi2c00711_si_001-36-32-39
Average 95 stars, based on 1 article reviews
p propargyloxyl l phenylalanine - by Bioz Stars, 2026-11
95/100 stars
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tnf  (RayBiotech inc)
91
RayBiotech inc tnf
Functional evaluation of IRAK-4 signaling. (A) Pro-inflammatory cytokine quantification in sera using Meso Scale Discovery. Healthy controls (black circles), heterozygote parents (dark grey inverted triangles) and compound heterozygotes from Family A (light grey squares) and Family B (light grey diamonds), are shown. (B) NF-κB signaling assessed via flow cytometry analysis of phosphorylated-p65 (P-p65) stimulated with ligands as indicated on x-axis, fold-change median fluorescence (MFI) from baseline at 20 minutes shown. (C) Analysis of interleukin-6 (IL-6) and tumor necrosis factor <t>(TNF)</t> production by peripheral blood mononuclear cells (PBMC) from Family A in response to <t>lipopolysaccharide</t> <t>(LPS)</t> stimulation. (D) STAT1 and (E) STAT3 signaling assessed via flow cytometry analysis of phosphorylated-STAT1 (p-STAT1) and STAT3 (p-STAT3) expression following stimulation with interferon α2b (IFN-α2b) at time points indicated on x axis. Horizontal lines at mean and standard error (SE) of the mean shown. Significance indicated by: *p < 0.05; ** p < 0.01; and ****p < 0.0001 and ns, not significant. TNF, tumor necrosis factor; IL, interleukin; IP-10, interferon-γ induced protein-10; MCP-1, monocyte chemoattractant protein-1; IFN, interferon; LPS, lipopolysaccharide; p-STAT1/3, phosphorylated signal transducer and activator of transcription 1/3; MFI, median fluorescence intensity.
Tnf, supplied by RayBiotech inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/00243/Recombinant+Human+TNFa/pmc10516541-86-8-9
Average 91 stars, based on 1 article reviews
tnf - by Bioz Stars, 2026-11
91/100 stars
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ptfe tubing  (Optimize Technologies)
90
Optimize Technologies ptfe tubing
Functional evaluation of IRAK-4 signaling. (A) Pro-inflammatory cytokine quantification in sera using Meso Scale Discovery. Healthy controls (black circles), heterozygote parents (dark grey inverted triangles) and compound heterozygotes from Family A (light grey squares) and Family B (light grey diamonds), are shown. (B) NF-κB signaling assessed via flow cytometry analysis of phosphorylated-p65 (P-p65) stimulated with ligands as indicated on x-axis, fold-change median fluorescence (MFI) from baseline at 20 minutes shown. (C) Analysis of interleukin-6 (IL-6) and tumor necrosis factor <t>(TNF)</t> production by peripheral blood mononuclear cells (PBMC) from Family A in response to <t>lipopolysaccharide</t> <t>(LPS)</t> stimulation. (D) STAT1 and (E) STAT3 signaling assessed via flow cytometry analysis of phosphorylated-STAT1 (p-STAT1) and STAT3 (p-STAT3) expression following stimulation with interferon α2b (IFN-α2b) at time points indicated on x axis. Horizontal lines at mean and standard error (SE) of the mean shown. Significance indicated by: *p < 0.05; ** p < 0.01; and ****p < 0.0001 and ns, not significant. TNF, tumor necrosis factor; IL, interleukin; IP-10, interferon-γ induced protein-10; MCP-1, monocyte chemoattractant protein-1; IFN, interferon; LPS, lipopolysaccharide; p-STAT1/3, phosphorylated signal transducer and activator of transcription 1/3; MFI, median fluorescence intensity.
Ptfe Tubing, supplied by Optimize Technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/00243/PTFE+Tubing/10__1016_slash_j__aca__2016__03__056-78-0-20
Average 90 stars, based on 1 article reviews
ptfe tubing - by Bioz Stars, 2026-11
90/100 stars
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mek7 rabbit mab  (Genecopoeia)
95
Genecopoeia mek7 rabbit mab
Functional evaluation of IRAK-4 signaling. (A) Pro-inflammatory cytokine quantification in sera using Meso Scale Discovery. Healthy controls (black circles), heterozygote parents (dark grey inverted triangles) and compound heterozygotes from Family A (light grey squares) and Family B (light grey diamonds), are shown. (B) NF-κB signaling assessed via flow cytometry analysis of phosphorylated-p65 (P-p65) stimulated with ligands as indicated on x-axis, fold-change median fluorescence (MFI) from baseline at 20 minutes shown. (C) Analysis of interleukin-6 (IL-6) and tumor necrosis factor <t>(TNF)</t> production by peripheral blood mononuclear cells (PBMC) from Family A in response to <t>lipopolysaccharide</t> <t>(LPS)</t> stimulation. (D) STAT1 and (E) STAT3 signaling assessed via flow cytometry analysis of phosphorylated-STAT1 (p-STAT1) and STAT3 (p-STAT3) expression following stimulation with interferon α2b (IFN-α2b) at time points indicated on x axis. Horizontal lines at mean and standard error (SE) of the mean shown. Significance indicated by: *p < 0.05; ** p < 0.01; and ****p < 0.0001 and ns, not significant. TNF, tumor necrosis factor; IL, interleukin; IP-10, interferon-γ induced protein-10; MCP-1, monocyte chemoattractant protein-1; IFN, interferon; LPS, lipopolysaccharide; p-STAT1/3, phosphorylated signal transducer and activator of transcription 1/3; MFI, median fluorescence intensity.
Mek7 Rabbit Mab, supplied by Genecopoeia, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/00243/MEK7+Rabbit+mAb/custom%40mab-00243%4031966701
Average 95 stars, based on 1 article reviews
mek7 rabbit mab - by Bioz Stars, 2026-11
95/100 stars
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Image Search Results


Functional evaluation of IRAK-4 signaling. (A) Pro-inflammatory cytokine quantification in sera using Meso Scale Discovery. Healthy controls (black circles), heterozygote parents (dark grey inverted triangles) and compound heterozygotes from Family A (light grey squares) and Family B (light grey diamonds), are shown. (B) NF-κB signaling assessed via flow cytometry analysis of phosphorylated-p65 (P-p65) stimulated with ligands as indicated on x-axis, fold-change median fluorescence (MFI) from baseline at 20 minutes shown. (C) Analysis of interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by peripheral blood mononuclear cells (PBMC) from Family A in response to lipopolysaccharide (LPS) stimulation. (D) STAT1 and (E) STAT3 signaling assessed via flow cytometry analysis of phosphorylated-STAT1 (p-STAT1) and STAT3 (p-STAT3) expression following stimulation with interferon α2b (IFN-α2b) at time points indicated on x axis. Horizontal lines at mean and standard error (SE) of the mean shown. Significance indicated by: *p < 0.05; ** p < 0.01; and ****p < 0.0001 and ns, not significant. TNF, tumor necrosis factor; IL, interleukin; IP-10, interferon-γ induced protein-10; MCP-1, monocyte chemoattractant protein-1; IFN, interferon; LPS, lipopolysaccharide; p-STAT1/3, phosphorylated signal transducer and activator of transcription 1/3; MFI, median fluorescence intensity.

Journal: Frontiers in Immunology

Article Title: Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4

doi: 10.3389/fimmu.2023.1231749

Figure Lengend Snippet: Functional evaluation of IRAK-4 signaling. (A) Pro-inflammatory cytokine quantification in sera using Meso Scale Discovery. Healthy controls (black circles), heterozygote parents (dark grey inverted triangles) and compound heterozygotes from Family A (light grey squares) and Family B (light grey diamonds), are shown. (B) NF-κB signaling assessed via flow cytometry analysis of phosphorylated-p65 (P-p65) stimulated with ligands as indicated on x-axis, fold-change median fluorescence (MFI) from baseline at 20 minutes shown. (C) Analysis of interleukin-6 (IL-6) and tumor necrosis factor (TNF) production by peripheral blood mononuclear cells (PBMC) from Family A in response to lipopolysaccharide (LPS) stimulation. (D) STAT1 and (E) STAT3 signaling assessed via flow cytometry analysis of phosphorylated-STAT1 (p-STAT1) and STAT3 (p-STAT3) expression following stimulation with interferon α2b (IFN-α2b) at time points indicated on x axis. Horizontal lines at mean and standard error (SE) of the mean shown. Significance indicated by: *p < 0.05; ** p < 0.01; and ****p < 0.0001 and ns, not significant. TNF, tumor necrosis factor; IL, interleukin; IP-10, interferon-γ induced protein-10; MCP-1, monocyte chemoattractant protein-1; IFN, interferon; LPS, lipopolysaccharide; p-STAT1/3, phosphorylated signal transducer and activator of transcription 1/3; MFI, median fluorescence intensity.

Article Snippet: Cells were then treated with either 100 ng/ml TNF (RayBiotech, 230-00243-50), LPS (Sigma Aldrich, L2880) or IFN-α2b (GenScript, 203002-50), or 1 μg/ml IL-1β (Aviscera Bioscience, 00756-01-59), for up to 60 minutes.

Techniques: Functional Assay, Flow Cytometry, Fluorescence, Expressing