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U73122 PLC u73122 plc β inhibitor
U73122 Plc β Inhibitor, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/u73122 plc β inhibitor/product/U73122 PLC
Average 86 stars, based on 1 article reviews
Price from $9.99 to $1999.99
u73122 plc β inhibitor - by Bioz Stars, 2021-05
86/100 stars

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Article Title: Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells
Article Snippet: We first pre-treated THP-1 cells for 1 h with 10 µM PD098059 (ERK inhibitor) , 30 µM U73122 (PLC-1γ inhibitor), 30 µM LY294002 (PI3 kinase inhibitor), 70 nM Gö6983 (PKC α/β inhibitor), 30 µM DPI (NADPH oxidase inhibitor) and 1 mM NAC (ROS scavenging antioxidant, which also leads to an increase in intracellular GSH levels) , , , .

Planar Chromatography:

Article Title: Trace amine–associated receptor 1 (TAAR1) promotes anti-diabetic signaling in insulin-secreting cells
Article Snippet: Likewise, reloading of intracellular calcium stores was partially required for activation of pERK1/2, as blockade of the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump with thapsigargin was able to reduce ERK phosphorylation in response to these agents ( A ). .. PLC-β, a common mediator of calcium signaling through Gq - and Gi -coupled receptors, however, was not required for TAAR1-initiated ERK1/2 phosphorylation, as the U73122 PLC-β inhibitor had no effect on T1 AM or forskolin-mediated ERK1/2 phosphorylation ( B ), an agonist of protease-activated receptor 2 (PAR2), a known Gq -coupled receptor expressed in the pancreas , confirming the efficacy of U73122 in these insulin-secreting cells. .. Ca2+/ Calmodulin (CaM) kinase–dependent signaling has been shown previously to regulate Raf/MEK/ERK pathways in certain cell types , providing a possible link between intracellular calcium and downstream ERK1/2 phosphorylation.

Inhibition:

Article Title: Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.
Article Snippet: .. Notably, as shown in Fig. 4, the RELM-β-induced inhibition of the KCNK3 protein was abrogated by U73122 (PLC inhibitor) (Fig. 4A) and Y-27632 (Rho kinase inhibitor) (Fig. 4B). .. Under hypoxia, U-73122 could also reverse this inhibition (Fig. 4D); however, Y-27632 failed to function (Fig. 4E).

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    U73122 PLC u73122 plc β inhibitor
    U73122 Plc β Inhibitor, supplied by U73122 PLC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/u73122 plc β inhibitor/product/U73122 PLC
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    u73122 plc β inhibitor - by Bioz Stars, 2021-05
    86/100 stars
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