Review





Similar Products

leica m165c stereoscopic microscope  (Danaher Inc)
96
Danaher Inc leica m165c stereoscopic microscope
Leica M165c Stereoscopic Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/Leica+M165+C+Encoded+Stereo+Microscopes/pm42909524-58-25-25
Average 96 stars, based on 1 article reviews
leica m165c stereoscopic microscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
szx16 research stereo zoom microscope  (Olympus)
96
Olympus szx16 research stereo zoom microscope
Szx16 Research Stereo Zoom Microscope, supplied by Olympus, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/SZX16+Research+Stereo+Microscope+System/pmc13692848-285-8-13
Average 96 stars, based on 1 article reviews
szx16 research stereo zoom microscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
leica m165 fc stereomicroscope  (Danaher Inc)
96
Danaher Inc leica m165 fc stereomicroscope
Leica M165 Fc Stereomicroscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/Leica+M165+FC+Fluorescent+Stereo+Microscope/pmc13690901-56-12-12
Average 96 stars, based on 1 article reviews
leica m165 fc stereomicroscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
stereo discovery v12 dissecting microscope  (Carl Zeiss)
96
Carl Zeiss stereo discovery v12 dissecting microscope
Stereo Discovery V12 Dissecting Microscope, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/SteREO+Discovery%2EV12+microscope+body/pmc13689684-214-7-11
Average 96 stars, based on 1 article reviews
stereo discovery v12 dissecting microscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
bright field stereomicroscope  (Danaher Inc)
96
Danaher Inc bright field stereomicroscope
Bright Field Stereomicroscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/M205+FCA+Fluorescence+Stereo+Microscopes/pmc13689988-123-7-9
Average 96 stars, based on 1 article reviews
bright field stereomicroscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
stereo discovery v8 microscope zeiss  (Carl Zeiss)
96
Carl Zeiss stereo discovery v8 microscope zeiss
Stereo Discovery V8 Microscope Zeiss, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/SteREO+Discovery%2EV8+microscope+body/pm42907582-449-9-13
Average 96 stars, based on 1 article reviews
stereo discovery v8 microscope zeiss - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
stereomicroscope  (Danaher Inc)
96
Danaher Inc stereomicroscope
( A ) scRNA-seq workflow. Created in BioRender. Kadota, C. (2026) https://BioRender.com/ks47d2b . ( B ) UMAP visualization of cell types in TMJ. Chondrocytes are highlighted in blue. ( C ) Proportion of each cell cluster in p75 +/+ and p75 −/− MCCs. ( D ) Pathway analysis of chondrocytes identified by scRNA-seq. ( E ) <t>Stereomicroscope</t> images and gross pellet size. Scale bar, 500 μm. ( F ) Safranin O staining [Top: Whole-pellet view (10×; scale bar, 500 μm); bottom, 40× view of the dotted area. Scale bar, 100 μm] and quantification of Safranin O–positive area, and ( G ) gene expression analyses ( Acan , Ihh , Sox9 , and Col2a1 ) of p75 +/+ and p75 −/− mBMSCs underwent 3D pellet culture ( N = 6 per group). ( H ) Left: Western blotting of p75 NTR , phosphorylated-AKT, AKT, phosphorylated-p38, and p38 in mBMSCs treated with vehicle or BDNF. Right: Quantification of p-AKT/AKT and p-p38/p38 ratios. ( N = 5 independent experiments). ( I ) Gene expression analyses in p75 +/+ and p75 −/− condyles for p75 NTR , Ntrk2 , Bdnf , Trp53 , Bax , Acan , Ihh , Sox9 , Col2a1 , and Mki67 ( N = 5 per group). IF staining for ( J ) Ki-67 and ( K ) TUNEL and quantification of Ki-67 and TUNEL-positive cells in p75 +/+ and p75 −/− TMJ ( N = 5 per group). Blue, DAPI. Scale bar, 50 μm. ( L ) Cell proliferation assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). ( M ) Apoptosis assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). Statistical significance was determined using unpaired two-sided Student’s t test or two-way ANOVA, as appropriate. Bonferroni correction was applied for pairwise post hoc comparisons following two-way ANOVA. Results are represented as the means ± 1 SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. N represents the number of mice or experimental replicates.
Stereomicroscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/M205+FA+Fluorescence+Stereo+Microscopes/pmc13685922-328-16-17
Average 96 stars, based on 1 article reviews
stereomicroscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
stereo microscope  (Olympus)
96
Olympus stereo microscope
( A ) scRNA-seq workflow. Created in BioRender. Kadota, C. (2026) https://BioRender.com/ks47d2b . ( B ) UMAP visualization of cell types in TMJ. Chondrocytes are highlighted in blue. ( C ) Proportion of each cell cluster in p75 +/+ and p75 −/− MCCs. ( D ) Pathway analysis of chondrocytes identified by scRNA-seq. ( E ) <t>Stereomicroscope</t> images and gross pellet size. Scale bar, 500 μm. ( F ) Safranin O staining [Top: Whole-pellet view (10×; scale bar, 500 μm); bottom, 40× view of the dotted area. Scale bar, 100 μm] and quantification of Safranin O–positive area, and ( G ) gene expression analyses ( Acan , Ihh , Sox9 , and Col2a1 ) of p75 +/+ and p75 −/− mBMSCs underwent 3D pellet culture ( N = 6 per group). ( H ) Left: Western blotting of p75 NTR , phosphorylated-AKT, AKT, phosphorylated-p38, and p38 in mBMSCs treated with vehicle or BDNF. Right: Quantification of p-AKT/AKT and p-p38/p38 ratios. ( N = 5 independent experiments). ( I ) Gene expression analyses in p75 +/+ and p75 −/− condyles for p75 NTR , Ntrk2 , Bdnf , Trp53 , Bax , Acan , Ihh , Sox9 , Col2a1 , and Mki67 ( N = 5 per group). IF staining for ( J ) Ki-67 and ( K ) TUNEL and quantification of Ki-67 and TUNEL-positive cells in p75 +/+ and p75 −/− TMJ ( N = 5 per group). Blue, DAPI. Scale bar, 50 μm. ( L ) Cell proliferation assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). ( M ) Apoptosis assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). Statistical significance was determined using unpaired two-sided Student’s t test or two-way ANOVA, as appropriate. Bonferroni correction was applied for pairwise post hoc comparisons following two-way ANOVA. Results are represented as the means ± 1 SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. N represents the number of mice or experimental replicates.
Stereo Microscope, supplied by Olympus, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/SZX7+Stereomicroscope+System/pm42905511-283-14-17
Average 96 stars, based on 1 article reviews
stereo microscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier
leica m205a microscope  (Danaher Inc)
96
Danaher Inc leica m205a microscope
( A ) scRNA-seq workflow. Created in BioRender. Kadota, C. (2026) https://BioRender.com/ks47d2b . ( B ) UMAP visualization of cell types in TMJ. Chondrocytes are highlighted in blue. ( C ) Proportion of each cell cluster in p75 +/+ and p75 −/− MCCs. ( D ) Pathway analysis of chondrocytes identified by scRNA-seq. ( E ) <t>Stereomicroscope</t> images and gross pellet size. Scale bar, 500 μm. ( F ) Safranin O staining [Top: Whole-pellet view (10×; scale bar, 500 μm); bottom, 40× view of the dotted area. Scale bar, 100 μm] and quantification of Safranin O–positive area, and ( G ) gene expression analyses ( Acan , Ihh , Sox9 , and Col2a1 ) of p75 +/+ and p75 −/− mBMSCs underwent 3D pellet culture ( N = 6 per group). ( H ) Left: Western blotting of p75 NTR , phosphorylated-AKT, AKT, phosphorylated-p38, and p38 in mBMSCs treated with vehicle or BDNF. Right: Quantification of p-AKT/AKT and p-p38/p38 ratios. ( N = 5 independent experiments). ( I ) Gene expression analyses in p75 +/+ and p75 −/− condyles for p75 NTR , Ntrk2 , Bdnf , Trp53 , Bax , Acan , Ihh , Sox9 , Col2a1 , and Mki67 ( N = 5 per group). IF staining for ( J ) Ki-67 and ( K ) TUNEL and quantification of Ki-67 and TUNEL-positive cells in p75 +/+ and p75 −/− TMJ ( N = 5 per group). Blue, DAPI. Scale bar, 50 μm. ( L ) Cell proliferation assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). ( M ) Apoptosis assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). Statistical significance was determined using unpaired two-sided Student’s t test or two-way ANOVA, as appropriate. Bonferroni correction was applied for pairwise post hoc comparisons following two-way ANOVA. Results are represented as the means ± 1 SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. N represents the number of mice or experimental replicates.
Leica M205a Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stereo+microscope/Leica+M205+A+Encoded+Stereo+Microscopes/pmc13682889-136-10-10
Average 96 stars, based on 1 article reviews
leica m205a microscope - by Bioz Stars, 2026-11
96/100 stars
  Buy from Supplier

Image Search Results


( A ) scRNA-seq workflow. Created in BioRender. Kadota, C. (2026) https://BioRender.com/ks47d2b . ( B ) UMAP visualization of cell types in TMJ. Chondrocytes are highlighted in blue. ( C ) Proportion of each cell cluster in p75 +/+ and p75 −/− MCCs. ( D ) Pathway analysis of chondrocytes identified by scRNA-seq. ( E ) Stereomicroscope images and gross pellet size. Scale bar, 500 μm. ( F ) Safranin O staining [Top: Whole-pellet view (10×; scale bar, 500 μm); bottom, 40× view of the dotted area. Scale bar, 100 μm] and quantification of Safranin O–positive area, and ( G ) gene expression analyses ( Acan , Ihh , Sox9 , and Col2a1 ) of p75 +/+ and p75 −/− mBMSCs underwent 3D pellet culture ( N = 6 per group). ( H ) Left: Western blotting of p75 NTR , phosphorylated-AKT, AKT, phosphorylated-p38, and p38 in mBMSCs treated with vehicle or BDNF. Right: Quantification of p-AKT/AKT and p-p38/p38 ratios. ( N = 5 independent experiments). ( I ) Gene expression analyses in p75 +/+ and p75 −/− condyles for p75 NTR , Ntrk2 , Bdnf , Trp53 , Bax , Acan , Ihh , Sox9 , Col2a1 , and Mki67 ( N = 5 per group). IF staining for ( J ) Ki-67 and ( K ) TUNEL and quantification of Ki-67 and TUNEL-positive cells in p75 +/+ and p75 −/− TMJ ( N = 5 per group). Blue, DAPI. Scale bar, 50 μm. ( L ) Cell proliferation assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). ( M ) Apoptosis assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). Statistical significance was determined using unpaired two-sided Student’s t test or two-way ANOVA, as appropriate. Bonferroni correction was applied for pairwise post hoc comparisons following two-way ANOVA. Results are represented as the means ± 1 SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. N represents the number of mice or experimental replicates.

Journal: Science Advances

Article Title: p75 NTR orchestrates chondrogenesis and mechanoadaptation to preserve temporomandibular joint development and homeostasis

doi: 10.1126/sciadv.aef7786

Figure Lengend Snippet: ( A ) scRNA-seq workflow. Created in BioRender. Kadota, C. (2026) https://BioRender.com/ks47d2b . ( B ) UMAP visualization of cell types in TMJ. Chondrocytes are highlighted in blue. ( C ) Proportion of each cell cluster in p75 +/+ and p75 −/− MCCs. ( D ) Pathway analysis of chondrocytes identified by scRNA-seq. ( E ) Stereomicroscope images and gross pellet size. Scale bar, 500 μm. ( F ) Safranin O staining [Top: Whole-pellet view (10×; scale bar, 500 μm); bottom, 40× view of the dotted area. Scale bar, 100 μm] and quantification of Safranin O–positive area, and ( G ) gene expression analyses ( Acan , Ihh , Sox9 , and Col2a1 ) of p75 +/+ and p75 −/− mBMSCs underwent 3D pellet culture ( N = 6 per group). ( H ) Left: Western blotting of p75 NTR , phosphorylated-AKT, AKT, phosphorylated-p38, and p38 in mBMSCs treated with vehicle or BDNF. Right: Quantification of p-AKT/AKT and p-p38/p38 ratios. ( N = 5 independent experiments). ( I ) Gene expression analyses in p75 +/+ and p75 −/− condyles for p75 NTR , Ntrk2 , Bdnf , Trp53 , Bax , Acan , Ihh , Sox9 , Col2a1 , and Mki67 ( N = 5 per group). IF staining for ( J ) Ki-67 and ( K ) TUNEL and quantification of Ki-67 and TUNEL-positive cells in p75 +/+ and p75 −/− TMJ ( N = 5 per group). Blue, DAPI. Scale bar, 50 μm. ( L ) Cell proliferation assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). ( M ) Apoptosis assay of mBMSCs derived from p75 +/+ and p75 −/− mice ( N = 5 per group). Statistical significance was determined using unpaired two-sided Student’s t test or two-way ANOVA, as appropriate. Bonferroni correction was applied for pairwise post hoc comparisons following two-way ANOVA. Results are represented as the means ± 1 SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. N represents the number of mice or experimental replicates.

Article Snippet: For histological and morphometric analysis, pellets were cultured for 3 weeks and first imaged using a stereomicroscope (LEICA M205 FA; Leica Microsystems).

Techniques: Analysis, Staining, Gene Expression, Western Blot, TUNEL Assay, Proliferation Assay, Derivative Assay, Apoptosis Assay, Single Cell, RNA Sequencing, Real-time Polymerase Chain Reaction