Journal: Cancer Medicine
Article Title: STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS‐Dependent PTEN/AKT1 Signaling
doi: 10.1002/cam4.70958
Figure Lengend Snippet: STOX1‐A promotes tumorigenesis of HCC cells in vivo. (A) Schematic model of subcutaneous injection of the indicated tumor cells in vivo. (B, C) The effect of STOX1‐A overexpression or downexpression on the tumor weight (B) and volume (C) in the indicated mice group, including vector‐overexpression group (Vec‐OE), STOX1‐A overexpression group (STOX1A), vector‐shRNA group (Vec‐sh) and STOX1‐A overexpression group (sh#1). (D) H&E staining analysis of necrotic areas in the tumors from the indicated mice group (left panel). Analysis of necrotic areas in the indicated tumor tissues (right panel). n.s., no significant difference. (E, F) Analysis of Ki‐67 (E) and STOX1‐A (F) expression in the tumor tissues from the indicated mice group.
Article Snippet: Small interfering RNA (siRNA) knockdown was obtained from Ribobio (Guangzhou, China).
Techniques: In Vivo, Injection, Over Expression, Plasmid Preparation, shRNA, Staining, Expressing