Journal: The Indian Journal of Medical Research
Article Title: Azithromycin resistance mechanisms in typhoidal salmonellae in India: A 25 years analysis
doi: 10.4103/ijmr.IJMR_1302_17
Figure Lengend Snippet: ( A ). Scatterplot of azithromycin minimum inhibitory concentration (MIC) vs. zone diameter (zone of inhibition, ZOI) for 469 isolates of Salmonella Typhi showing concordance between Clinical and Laboratory Standards Institute (CLSI) breakpoint (ZOI ≥14 mm and MIC ≤16 μl/ml) and determined epidemiological cut-off MIC ≤16 μl/ml), (B). Scatterplot of azithromycin MIC vs. zone diameter for S. paratyphi A, showing lower zone diameter and higher MICdistribution than S. Typhi. Both plots show the relationship between the MIC to azithromycin (y-axis) and the inhibition zone diameters (x-axis). The dotted line denotes the cut-off for susceptible/resistant as per CLSI, 2015 .
Article Snippet: RplV gene had mutations in two isolates of S. Typhi, one had A208 to C transversion resulting in amino acid change from lysine to threonine at position 70 of L22 protein. depicts the amino acid sequence alignment of mutant rplV sequences with reference strain of S. Typhi ATCC 19430-Ty2.
Techniques: Concentration Assay, Inhibition