ro4 1284  (Millipore)


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  • 94
    Name:
    Ro 4 1284
    Description:

    Catalog Number:
    r9157
    Price:
    None
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    Structured Review

    Millipore ro4 1284
    Ro 4 1284

    https://www.bioz.com/result/ro4 1284/product/Millipore
    Average 94 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    ro4 1284 - by Bioz Stars, 2020-09
    94/100 stars

    Images

    1) Product Images from "Vesicular Monoamine Transporter 2 and the Acute and Long-Term Response to 3,4-(±)-Methylenedioxymethamphetamine"

    Article Title: Vesicular Monoamine Transporter 2 and the Acute and Long-Term Response to 3,4-(±)-Methylenedioxymethamphetamine

    Journal: Toxicological Sciences

    doi: 10.1093/toxsci/kfu222

    Ro4-1284 pretreatment affords protection against long-lasting MDMA-induced tissue 5-HT depletions. 5-HT and 5-HIAA levels were measured from cortex (A, C) and striatum (B, D) 7 days after MDMA exposure by HPLC-CEAS. Ro4-1284 (10 mg/kg, ip) was
    Figure Legend Snippet: Ro4-1284 pretreatment affords protection against long-lasting MDMA-induced tissue 5-HT depletions. 5-HT and 5-HIAA levels were measured from cortex (A, C) and striatum (B, D) 7 days after MDMA exposure by HPLC-CEAS. Ro4-1284 (10 mg/kg, ip) was

    Techniques Used: High Performance Liquid Chromatography

    Acute effects of Ro4-1284 on striatal indoleamine and catecholamine content. Concentrations of 5-HT, DA, and corresponding metabolites, 5HIAA and DOPAC were assessed in rat striatum 1 and 12 h following Ro4-1284 (10 mg/kg, ip) treatment
    Figure Legend Snippet: Acute effects of Ro4-1284 on striatal indoleamine and catecholamine content. Concentrations of 5-HT, DA, and corresponding metabolites, 5HIAA and DOPAC were assessed in rat striatum 1 and 12 h following Ro4-1284 (10 mg/kg, ip) treatment

    Techniques Used:

    Ro4-1284 pretreatment attenuates horizontal velocity and vertical activity in MDMA-treated rats. Locomotor activity was monitored by placing animals into open-field activity chambers. Baseline levels of locomotor activity were measured for 30 min,
    Figure Legend Snippet: Ro4-1284 pretreatment attenuates horizontal velocity and vertical activity in MDMA-treated rats. Locomotor activity was monitored by placing animals into open-field activity chambers. Baseline levels of locomotor activity were measured for 30 min,

    Techniques Used: Activity Assay

    MDMA-mediated hyperthermia is absent in Ro4-1284-treated rats. Temperature probes implanted into the peritoneal cavity of Sprague-Dawley rats recorded core body temperature. Animals were given Ro4-1284 (10 mg/kg, ip) 1 h prior to MDMA
    Figure Legend Snippet: MDMA-mediated hyperthermia is absent in Ro4-1284-treated rats. Temperature probes implanted into the peritoneal cavity of Sprague-Dawley rats recorded core body temperature. Animals were given Ro4-1284 (10 mg/kg, ip) 1 h prior to MDMA

    Techniques Used:

    Long-term effects of Ro4-1284 and MDMA on striatal catecholamine content. DA and DOPAC concentrations were measured from striatum 7 days after MDMA exposure by HPLC-CEAS. Ro4-1284 (10 mg/kg, ip) was administered 1 h prior to MDMA treatment
    Figure Legend Snippet: Long-term effects of Ro4-1284 and MDMA on striatal catecholamine content. DA and DOPAC concentrations were measured from striatum 7 days after MDMA exposure by HPLC-CEAS. Ro4-1284 (10 mg/kg, ip) was administered 1 h prior to MDMA treatment

    Techniques Used: High Performance Liquid Chromatography

    Loss of striatal serotonergic nerve-terminal density following MDMA dosing is prevented with Ro4-1284 treatment. Representative images of rat striatum were captured by light microscopy. Coronal sections were stained for SERT in animals treated with saline,
    Figure Legend Snippet: Loss of striatal serotonergic nerve-terminal density following MDMA dosing is prevented with Ro4-1284 treatment. Representative images of rat striatum were captured by light microscopy. Coronal sections were stained for SERT in animals treated with saline,

    Techniques Used: Light Microscopy, Staining

    Related Articles

    Injection:

    Article Title: Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
    Article Snippet: .. To inhibit monoaminergic vesicular transport and deplete transmitter-filled vesicles, Slc6a3 IRES-Cre mice were injected intraperitoneally with either the irreversible VMAT inhibitor reserpine (5 mg·kg−1 ) 24 h prior to slicing, the reversible VMAT antagonist Ro4-1284 (Sigma, 15 mg·kg−1 ) 1 h prior to slicing, or the competitive and selective VMAT2 antagonist tetrabenazine (TBZ; 5 mg·kg−1 ) 2 h prior to slicing. .. To deplete presynaptic terminals of dopamine, Slc6a3 IRES-Cre mice were administered the tyrosine hydroxylase antagonist α-methyl-DL-tyrosine methyl ester hydrochloride (αMT; Sigma, 250 mg·kg−1 i.p.) 3 h and 1 h before slicing.

    other:

    Article Title: Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity
    Article Snippet: The VMAT2 inhibitor, Ro 4-1284 (2-hydroxy-2-ethyl-3-isobutyl-9, 10-dimethoxy-1, 2, 3, 4, 5, 6, 7-hexahydrobenzo[a]chinolizine), was purchased from Sigma-Aldrich.

    Article Title: Vesicular Monoamine Transporter 2 and the Acute and Long-Term Response to 3,4-(±)-Methylenedioxymethamphetamine
    Article Snippet: The VMAT2 inhibitor, Ro4-1284 (2-hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine), was also purchased from Sigma-Aldrich.

    Mouse Assay:

    Article Title: Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
    Article Snippet: .. To inhibit monoaminergic vesicular transport and deplete transmitter-filled vesicles, Slc6a3 IRES-Cre mice were injected intraperitoneally with either the irreversible VMAT inhibitor reserpine (5 mg·kg−1 ) 24 h prior to slicing, the reversible VMAT antagonist Ro4-1284 (Sigma, 15 mg·kg−1 ) 1 h prior to slicing, or the competitive and selective VMAT2 antagonist tetrabenazine (TBZ; 5 mg·kg−1 ) 2 h prior to slicing. .. To deplete presynaptic terminals of dopamine, Slc6a3 IRES-Cre mice were administered the tyrosine hydroxylase antagonist α-methyl-DL-tyrosine methyl ester hydrochloride (αMT; Sigma, 250 mg·kg−1 i.p.) 3 h and 1 h before slicing.