Journal: Clinical transplantation
Article Title: Leukocyte Transcriptome Indicators of Development of Infection in Kidney Transplant Recipients
doi: 10.1111/ctr.14252
Figure Lengend Snippet: Top 25 downregulated genes in kidney transplant recipients with infection compared with those without infection
Article Snippet: Additional genes up to 1.3x downregulated are shown in are shown in Supplementary Material ( Appendix 2 ). table ft1 table-wrap mode="anchored" t5 Table 4: caption a7 Downregulated genes Alias Fold difference Function 1 CCL4L1 C-C Motif Chemokine Ligand 4 Like 1 1.72 Pro-inflammatory 2 IL1B Interleukin 1 Beta 1.70 Pro-inflammatory 3 CCL4L2 C-C Motif Chemokine Ligand 4 Like 2 1.69 Pro-inflammatory 4 CCL3L1 C-C Motif Chemokine Ligand 3 Like 1 1.67 Pro-inflammatory 5 GSTM2 Glutathione S-Transferase Mu 2 1.64 Metabolism 6 CCL3L3 C-C Motif Chemokine Ligand 3 Like 3 1.63 Pro-inflammatory 7 GSTM1 Glutathione S-Transferase Mu 1 1.62 Metabolism 8 CCL3 C-C Motif Chemokine Ligand 3 1.60 Pro-inflammatory 9 TNF Tumor Necrosis Factor 1.54 Pro-inflammatory 10 SNORD3D Small Nucleolar RNA, C/D Box 3D 1.52 Metabolism 11 CD83 CD83 Molecule 1.50 Adaptive immune response 12 SNORD13 Small Nucleolar RNA, C/D Box 1.48 Metabolism 13 HLA-A29.1 Major Histocompatibility Complex, Class I, A 1.48 Adaptive immune response 14 RNU11 RNA, U11 Small Nuclear 1.47 Metabolism 15 HLA-DQB1 Major Histocompatibility Complex, Class II, DQ Beta 1 1.45 Adaptive immune response 16 SNORD3A Small Nucleolar RNA, C/D Box 3A 1.44 Metabolism 17 MYOM2 Myomesin 2 1.43 Structure 18 FGFBP2 Fibroblast Growth Factor Binding Protein 2 1.42 Adaptive immune response 19 SGK1 Serum/Glucocorticoid Regulated Kinase 1 1.40 Metabolism 20 SGK Serum/Glucocorticoid Regulated Kinase 1.39 Metabolism 21 OLIG1 Oligodendrocyte Transcription Factor 1 1.39 Transcriptional regulation 22 CD160 CD160 Molecule 1.38 Adaptive immune response 23 FCRLA Fc Receptor Like A 1.38 Adaptive immune response 24 RPPH1 Ribonuclease P RNA Component H1 1.38 Transcriptional regulation 25 GPR56 Adhesion G Protein-Coupled Receptor G1 1.38 Cell signaling Open in a separate window Top 25 downregulated genes in kidney transplant recipients with infection compared with those without infection Expression-based monitoring of transcription factor activity for infection We used the “Transcription Element Listening System” (TELiS) bioinformatics analysis to evaluate upregulated and downregulated transcripts with respect to the distribution of transcription factor-binding motifs (TFBMs) present in their core promoter sequences in order to identify alterations in transcription control pathways that might drive the observed empirical transcriptome differences, we used.
Techniques: Infection, Binding Assay
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