Journal: International Journal of Molecular Sciences
Article Title: Association Between Pentraxins and Obesity in Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus Patients
doi: 10.3390/ijms26083661
Figure Lengend Snippet: Figure 4. Receiver operating characteristic (ROC) curve for IL-6 (A), PTX3 (B), MCVL (C), TNF-α (D), hs-CRP (E), PLR (F), SII (G), NLR (H), MLR (I), IIC (J), and AISI (K). ROC analysis showed that the PTX3 (AUC was 0.720; p = 0.003; cut-off value 1888.00 pg/mL, with 67.60% sensitivity and the highest specificity of 73.30%) and MCVL index (AUC was 0.677; p = 0.047; cut-off value 39.60, with 63.30% sensitivity and the second highest specificity of 66.70%) had a good accurate diagnosis compared with IL-6 (AUC was 0.866; p < 0.0001; cut-off value 40.30 pg/mL, with 100.00% sensitivity and 60.00% specificity). IIC showed 61.70% sensitivity and 60.00% specificity, with an AUC of 0.572, p = 0.027, and a cut-off value of 2.35. In our study, we found the following results for various hematological indices: PLR demonstrated 73.30% sensitivity and 60.00% specificity (cut-off value of 101); SII exhibited 56.70% sensitivity and 60.00% specificity (cut-off value of 397); NLR showed a sensitivity of 65.00% and a specificity of 60.00% (cut-off value of 1.98); MLR had a sensitivity of 53.30% and a specificity of 56.70% (cut-off value of 0.212); while AISI demonstrated a sensitivity of 56.70% and a specificity of 53.30% (cut-off value of 233). PTX3: pentraxin 3; hs-CRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor alpha; IL-6: interleukin 6; NLR: neutrophil-lymphocyte ratio; MLR: monocyte-lymphocyte ratio; PLR: platelet-lymphocyte ratio; AISI: aggregate index of systemic inflammation; SII: systemic immune-inflammation index; MCVL: ratio between the mean corpuscular volume/lymphocytes; IIC: cumulative inflammatory index.
Article Snippet: For each of the following mediators, we used commercially available test sets: PTX3 (Catalog# E-EL-H6081; sensitivity: 4.12 pg/mL; detection range: 6.86–5000 pg/mL), hs-CRP (Catalog# E-EL-H5134; sensitivity: 9.38 pg/mL; detection range: 15.63–1000 pg/mL), from the Elabscience (Houston, TX, USA); TNF-α (Catalog# BMS223-4; sensitivity: 2.3 pg/mL; assay range: 7.8–500 pg/mL), IL-6 (Catalog# BMS213-2; sensitivity: 0.92 pg/mL; assay range: 1.56–100 pg/mL), from Invitrogen, Thermo Fisher Scientific, Inc. (Waltham, MA, USA).
Techniques: Biomarker Discovery
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