phospho histone h2a x ser139 d7t2v mouse mab  (Cell Signaling Technology Inc)


Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse mab
    Phospho Histone H2a X Ser139 D7t2v Mouse Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho histone h2a x ser139 d7t2v mouse mab/product/Cell Signaling Technology Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phospho histone h2a x ser139 d7t2v mouse mab - by Bioz Stars, 2024-09
    86/100 stars

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    phospho histone h2a x ser139 d7t2v mouse mab  (Cell Signaling Technology Inc)


    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse mab
    (A) Major pathways whose expression is dependent on R-loops present only in CIN 612 cells as determined by RNase H1 overexpression. Pathway analysis was performed using the Hallmark database in Shiny GO 0.80 of R-loop regulated genes that contain R-loops unique to the CIN 612 cells. (B) Innate immune response genes whose expression is regulated by R-loops that are present only in CIN 612 cells. Fold changes are normalized to the mRNA counts in normal keratinocytes (n = 2). Linkages to H3K36me3 and γH2AX histones are shown on the right.
    Phospho Histone H2a X Ser139 D7t2v Mouse Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho histone h2a x ser139 d7t2v mouse mab/product/Cell Signaling Technology Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phospho histone h2a x ser139 d7t2v mouse mab - by Bioz Stars, 2024-09
    86/100 stars

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    1) Product Images from "HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways"

    Article Title: HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways

    Journal: PLOS Pathogens

    doi: 10.1371/journal.ppat.1012454

    (A) Major pathways whose expression is dependent on R-loops present only in CIN 612 cells as determined by RNase H1 overexpression. Pathway analysis was performed using the Hallmark database in Shiny GO 0.80 of R-loop regulated genes that contain R-loops unique to the CIN 612 cells. (B) Innate immune response genes whose expression is regulated by R-loops that are present only in CIN 612 cells. Fold changes are normalized to the mRNA counts in normal keratinocytes (n = 2). Linkages to H3K36me3 and γH2AX histones are shown on the right.
    Figure Legend Snippet: (A) Major pathways whose expression is dependent on R-loops present only in CIN 612 cells as determined by RNase H1 overexpression. Pathway analysis was performed using the Hallmark database in Shiny GO 0.80 of R-loop regulated genes that contain R-loops unique to the CIN 612 cells. (B) Innate immune response genes whose expression is regulated by R-loops that are present only in CIN 612 cells. Fold changes are normalized to the mRNA counts in normal keratinocytes (n = 2). Linkages to H3K36me3 and γH2AX histones are shown on the right.

    Techniques Used: Expressing, Over Expression

    (A) mRNA levels of genes γH2AX that are negative or positive in HFKs (left) and CIN 612 (right) cells. The red line represents the mean. The error bars are SEM (p<0.05, *; p<0.0001, ****). (B) Venn diagrams of the genes containing γH2AX and R-loop peaks (MACS) overlapping between the HFKs (left) and CIN 612 (right) cells (n = 2). Genes containing γH2AX peaks (red), R-loop peaks (green), and both (brown). P-values represent that the overlap between genic marks is above or below that expected from random distribution. RF represents representation factors. RF values greater than 1 suggest more overlap than expected from random distribution, while RF values less than 1 imply less overlap. (C) Venn diagrams of the genes containing γH2AX, H3K36me3, and R-loops in CIN 612 cells (left) and the GO biological processes pathway analysis of these genes (right). (D) A table showing DNA repair and metabolism genes that are differentially expressed in CIN 612 cells with corresponding marks of R-loops, γH2AX, and H3K36me3, which are present on these genes only in the precancerous cells.
    Figure Legend Snippet: (A) mRNA levels of genes γH2AX that are negative or positive in HFKs (left) and CIN 612 (right) cells. The red line represents the mean. The error bars are SEM (p<0.05, *; p<0.0001, ****). (B) Venn diagrams of the genes containing γH2AX and R-loop peaks (MACS) overlapping between the HFKs (left) and CIN 612 (right) cells (n = 2). Genes containing γH2AX peaks (red), R-loop peaks (green), and both (brown). P-values represent that the overlap between genic marks is above or below that expected from random distribution. RF represents representation factors. RF values greater than 1 suggest more overlap than expected from random distribution, while RF values less than 1 imply less overlap. (C) Venn diagrams of the genes containing γH2AX, H3K36me3, and R-loops in CIN 612 cells (left) and the GO biological processes pathway analysis of these genes (right). (D) A table showing DNA repair and metabolism genes that are differentially expressed in CIN 612 cells with corresponding marks of R-loops, γH2AX, and H3K36me3, which are present on these genes only in the precancerous cells.

    Techniques Used:

    phospho histone h2a x ser139 d7t2v mouse mab  (Cell Signaling Technology Inc)


    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse mab
    Western blot analysis of DNA damage and quantification of ROS in untreated (CTR) and AXI-treated cells. Histograms (A–C) summarize the relative expression change of one target after 6 days of treatment with AXI in each LC cell line. (D) Representative Western blot images for each target in LC cell lines. The analyzed targets are phospho-Histone <t>H2A.X</t> <t>(Ser139)</t> (γH2AX), Nrf2, Keap1. βActin is used as loading control. Panels (E, F) show the relative quantification of intracellular ROS production after 3 and 6 days of incubation, respectively. Values represent the mean ± S.E.M. of a minimum of three independent experiments. Significance is calculated by performing an unpaired t-test between the control and treated groups: *p<0.05; ** p<0.01; ***p<0.001.
    Phospho Histone H2a X Ser139 D7t2v Mouse Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho histone h2a x ser139 d7t2v mouse mab/product/Cell Signaling Technology Inc
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    phospho histone h2a x ser139 d7t2v mouse mab - by Bioz Stars, 2024-09
    86/100 stars

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    1) Product Images from "Exploring the multifaceted antitumor activity of axitinib in lung carcinoids"

    Article Title: Exploring the multifaceted antitumor activity of axitinib in lung carcinoids

    Journal: Frontiers in Endocrinology

    doi: 10.3389/fendo.2024.1433707

    Western blot analysis of DNA damage and quantification of ROS in untreated (CTR) and AXI-treated cells. Histograms (A–C) summarize the relative expression change of one target after 6 days of treatment with AXI in each LC cell line. (D) Representative Western blot images for each target in LC cell lines. The analyzed targets are phospho-Histone H2A.X (Ser139) (γH2AX), Nrf2, Keap1. βActin is used as loading control. Panels (E, F) show the relative quantification of intracellular ROS production after 3 and 6 days of incubation, respectively. Values represent the mean ± S.E.M. of a minimum of three independent experiments. Significance is calculated by performing an unpaired t-test between the control and treated groups: *p<0.05; ** p<0.01; ***p<0.001.
    Figure Legend Snippet: Western blot analysis of DNA damage and quantification of ROS in untreated (CTR) and AXI-treated cells. Histograms (A–C) summarize the relative expression change of one target after 6 days of treatment with AXI in each LC cell line. (D) Representative Western blot images for each target in LC cell lines. The analyzed targets are phospho-Histone H2A.X (Ser139) (γH2AX), Nrf2, Keap1. βActin is used as loading control. Panels (E, F) show the relative quantification of intracellular ROS production after 3 and 6 days of incubation, respectively. Values represent the mean ± S.E.M. of a minimum of three independent experiments. Significance is calculated by performing an unpaired t-test between the control and treated groups: *p<0.05; ** p<0.01; ***p<0.001.

    Techniques Used: Western Blot, Expressing, Control, Incubation

    d7t2v mouse monoclonal antibody  (Cell Signaling Technology Inc)


    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc d7t2v mouse monoclonal antibody
    D7t2v Mouse Monoclonal Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/d7t2v mouse monoclonal antibody/product/Cell Signaling Technology Inc
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    94/100 stars

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    phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies  (Cell Signaling Technology Inc)


    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies
    Phospho Histone H2a X Ser139 D7t2v Mouse Monoclonal Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies/product/Cell Signaling Technology Inc
    Average 94 stars, based on 1 article reviews
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    phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies - by Bioz Stars, 2024-09
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    mouse monoclonal 137 phospho histone h2a x ser139 d7t2v antibody  (Cell Signaling Technology Inc)


    Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
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    Cell Signaling Technology Inc mouse monoclonal 137 phospho histone h2a x ser139 d7t2v antibody
    Mouse Monoclonal 137 Phospho Histone H2a X Ser139 D7t2v Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mouse monoclonal 137 phospho histone h2a x ser139 d7t2v antibody/product/Cell Signaling Technology Inc
    Average 86 stars, based on 1 article reviews
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    mouse monoclonal 137 phospho histone h2a x ser139 d7t2v antibody - by Bioz Stars, 2024-09
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    • phospho histone h2a x ser139 d7t2v mouse mab  (Cell Signaling Technology Inc)
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse mab
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    phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies  (Cell Signaling Technology Inc)
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    Cell Signaling Technology Inc phospho histone h2a x ser139 d7t2v mouse monoclonal antibodies
    Phospho Histone H2a X Ser139 D7t2v Mouse Monoclonal Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    mouse monoclonal 137 phospho histone h2a x ser139 d7t2v antibody  (Cell Signaling Technology Inc)
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    Mouse Monoclonal 137 Phospho Histone H2a X Ser139 D7t2v Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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