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Risk and protective factors for subretinal fibrosis in neovascular age-related macular degeneration

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Risk and protective factors for subretinal fibrosis in neovascular age-related macular degeneration

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Injection

Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Injection, Saline

Pathways and molecules involved in the pathogenesis of subretinal fibrosis

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Pathways and molecules involved in the pathogenesis of subretinal fibrosis

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Derivative Assay