Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Risk and protective factors for subretinal fibrosis in neovascular age-related macular degeneration

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Injection

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Schematic illustrations for animal models of subretinal fibrosis. Several subretinal fibrosis animal models can be created using laser photocoagulation, subretinal injection of macrophage-rich peritoneal exudate cells, or subretinal injection of Matrigel. Created with BioRender.com. C3: Complement component 3; CFB: complement component factor B; CNV: choroidal neovascularization; FGF2: fibroblast growth factor 2; iNOS: inducible nitric oxide synthase; PBS: phosphate-buffered saline; PECs: peritoneal exudate cells; TGFβ: transforming growth factor-β; VEGF: vascular endothelial growth factor.

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Injection, Saline

Journal: Neural Regeneration Research

Article Title: Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

doi: 10.4103/NRR.NRR-D-23-01642

Figure Lengend Snippet: Pathways and molecules involved in the pathogenesis of subretinal fibrosis

Article Snippet: Pro-fibrotic , Transforming growth factor-β signaling pathway Wnt signaling pathway Phosphatidylinositol-3-kinase/Akt pathway Vascular endothelial growth factor/vascular endothelial growth factor receptor Platelet derived growth factor/platelet derived growth factor receptor-β Interleukin-6/interleukin-6 receptor Hypoxia-inducible factor-1α/p53/miRNA-34a/Klotho pathway MRTF-A-SRF pathway Connective tissue growth factor, fibroblast growth factor 2, platelet-activating factor receptor, Galectin-1, Yes-associated protein, adiponectin, methyltransferase-like 3, matrix metalloproteinase 12, peptidyl arginine deiminase-4, αB-Crystallin, Snail (SNIA1), cyclooxygenase-2, (pro)renin receptor, sphingosine-1-phosphate, γ-secretase.

Techniques: Derivative Assay

Journal: PLOS ONE

Article Title: Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study

doi: 10.1371/journal.pone.0311143

Figure Lengend Snippet: 5 targets highly expressed in myocardial tissue.

Article Snippet: The primary antibodies used were phosphatidylinositol 3-Kinase (PI3K) p110 alpha Monoclonal antibody (67071-1-Ig, Proteintech, China), Phospho- protein kinase B (AKT) Monoclonal antibody (66444-1-Ig, Proteintech, China), Phospho- mammalian target of rapamycin (mTOR) Monoclonal antibody (67778-1-Ig, Proteintech, China), and Alpha Tubulin Monoclonal antibody (66031-1-Ig, Proteintech, China).

Techniques:

Journal: PLOS ONE

Article Title: Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study

doi: 10.1371/journal.pone.0311143

Figure Lengend Snippet: Each (red circle) represents a sample data point. ns p≥0.05, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. OGD, Oxygen and Glucose Deprivation; WTM, Wortman-nin; MDRN-H, High Dose Medioresinol; PI3Kα, Phosphoinositide 3-kinase alpha; p-AKT, Phosphorylated Protein Kinase B; p-mTOR, Phosphorylated Mechanistic Target of Rapamycin.

Article Snippet: The primary antibodies used were phosphatidylinositol 3-Kinase (PI3K) p110 alpha Monoclonal antibody (67071-1-Ig, Proteintech, China), Phospho- protein kinase B (AKT) Monoclonal antibody (66444-1-Ig, Proteintech, China), Phospho- mammalian target of rapamycin (mTOR) Monoclonal antibody (67778-1-Ig, Proteintech, China), and Alpha Tubulin Monoclonal antibody (66031-1-Ig, Proteintech, China).

Techniques: