Review



pai1 pa1-9077  (Thermo Fisher)


Bioz Verified Symbol Thermo Fisher is a verified supplier
Bioz Manufacturer Symbol Thermo Fisher manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    Thermo Fisher pai1 pa1-9077
    ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with <t>PAI1)</t> from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .
    Pai1 Pa1 9077, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pai1 pa1-9077/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    pai1 pa1-9077 - by Bioz Stars, 2026-01
    90/100 stars

    Images

    1) Product Images from "The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis"

    Article Title: The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis

    Journal: EMBO Molecular Medicine

    doi: 10.1038/s44321-024-00107-0

    ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .
    Figure Legend Snippet: ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .

    Techniques Used: Staining, Labeling, Control, Imaging



    Similar Products

    pai1 pa1-9077  (Thermo Fisher)
    90
    Thermo Fisher pai1 pa1-9077
    ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with <t>PAI1)</t> from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .
    Pai1 Pa1 9077, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pai1 pa1-9077/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    pai1 pa1-9077 - by Bioz Stars, 2026-01
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .

    Journal: EMBO Molecular Medicine

    Article Title: The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis

    doi: 10.1038/s44321-024-00107-0

    Figure Lengend Snippet: ( A , B ) ASC and Congo-red-stained myocard from patients without ( A ) and with AA amyloidosis ( B ; 68 and 82-year old males, respectively). ( C – E ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue of a patient with AA amyloidosis, presenting high level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177 and MAB/MY6745). ( F , G ) Individual and merged confocal images of cardiac blood vessels (labeled with PAI1) from post-mortem tissue, presenting low level of SAA (labeled with MAS41676 and DM003) and ASC (labeled with AL177). ( H ) Graphical representation of the quantification of 100X confocal images for SAA and ASC. Each point represents one field of view, bars represent median. Integrated density was normalized by the mean value control. Data from one patient in each group are shown. ( I ) Confocal images from post-mortem tissue of a patient with AA amyloidosis showing accumulation of both SAA (MAS41676, magenta) and ASC (AL177, yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( J ) STED imaging of co-aggregation SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. ( K ) Confocal images from post-mortem tissue of patient with AA amyloidosis showing accumulation of both SAA (DM003, magenta) and ASC (MAB-ASC (MY6745), yellow) within the blood vessel border (labeled with PAI1) and in adjacent muscle cells. ( L ) STED imaging of co-aggregation of SAA (magenta) and ASC (yellow). Imaris 3D model shows the intricacy of SAA and ASC within these aggregates. .

    Article Snippet: PAI1 (PA1-9077, ThermoFisher), SAA (MAS41676, Invitrogen), ASC (clone AL177, AdipoGen) and ASC (MY6745, Mabylon) were used at 1:200 dilution, SAA (DM003, OriGene Technologies) was used at 1:20 dilution, all in saturating buffer, for 48 h at 4 °C.

    Techniques: Staining, Labeling, Control, Imaging