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ATCC norfloxacin
( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control <t>norfloxacin</t> against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.
Norfloxacin, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control <t>norfloxacin</t> against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.
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( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control <t>norfloxacin</t> against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.
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( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control <t>norfloxacin</t> against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.
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( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control <t>norfloxacin</t> against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.
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( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control norfloxacin against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.

Journal: Science Advances

Article Title: Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate

doi: 10.1126/sciadv.adn8117

Figure Lengend Snippet: ( A ) Chemical structure of the amphiphilic dendrimer AD1b . ( B ) Antibacterial activity of AD1b against bacterial strains. MSSA, methicillin-sensitive S. aureus ; MRSA, methicillin-resistant S. aureus ; VRE, vancomycin-resistant Enterococcus ; mcr-1, mobilized colistin resistance 1; NDM-1, New Delhi metallo-β-lactamase; KPC, K. pneumoniae carbapenemase. Time- and dose-dependent killing assay of AD1b on ( C ) E. coli MG1655, ( D ) the colistin-resistant E. coli ( mcr-1 bearing strain E. coli MG1655/pACYC184- mcr-1 ), ( E ) A. baumannii ATCC 17978, and ( F ) MDR A. baumannii ATCC BAA-1800. Data represent average values ± SD ( n = 3 per group). Contr, control; AD1b 6/12/24/48, AD1b (6, 12, 24, and 48 μg ml −1 , respectively); CT8, colistin (8.0 μg ml −1 ); Mer8, meropenem at 8.0 μg ml −1 . Development of resistance after 30 days of serial passaging using sub-MIC concentrations of AD1b and the positive control norfloxacin against ( G ) E. coli MG1655 and ( H ) A. baumannii ATCC 17978.

Article Snippet: As depicted in , AD1b remained effective against E. coli MG1655 and A. baumannii ATCC 17978 throughout the 30-day passaging period, while a high level of resistance against the positive control, norfloxacin, was observed for E. coli MG1655 and A. baumannii ATCC 17978, as shown by the 128- and 64-fold increased MIC values, respectively.

Techniques: Activity Assay, Control, Passaging, Positive Control