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tph2  (Novus Biologicals)
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Novus Biologicals tph2
Details of the antibodies used in immunofluorescence experiments
Tph2, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tph2 - by Bioz Stars, 2026-04
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Details of the antibodies used in immunofluorescence experiments

Journal: Alcoholism, Clinical and Experimental Research

Article Title: Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV ‐2 neuroinvasion

doi: 10.1111/acer.15000

Figure Lengend Snippet: Details of the antibodies used in immunofluorescence experiments

Article Snippet: TPH2 , Primary , NB100‐7455 , Novus Biologicals , 1:1000.

Techniques: Immunofluorescence

Effect of chronic intermittent EtOH (CIE) exposure on the TPH2 and ACE2 immunoreactivity in raphe magnus (RMG). Representative confocal images showing (A, D) TPH2 (green) (B, E) ACE2 (red) (C, F) TPH2‐ACE2 (yellow) positive neurons in RMG of air and CIE mice. Scale bar = 50 μm. Graph showing (G) % immunoreactive area for ACE2 and TPH2, (H) % immunoreactive area for TPH2‐ACE2 positive neurons, (I) Pearson correlation coefficient for TPH2‐ACE2 colocalization (J) Mander's overlap coefficient for TPH2‐ACE2 colocalization in RMG. Values ( n = 4 to 5/group) are represented as mean (±SEM) and the data were analyzed by unpaired Student's t ‐test with Welch's correction (* p < 0.05, ** p < 0.01 vs. air control).

Journal: Alcoholism, Clinical and Experimental Research

Article Title: Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV ‐2 neuroinvasion

doi: 10.1111/acer.15000

Figure Lengend Snippet: Effect of chronic intermittent EtOH (CIE) exposure on the TPH2 and ACE2 immunoreactivity in raphe magnus (RMG). Representative confocal images showing (A, D) TPH2 (green) (B, E) ACE2 (red) (C, F) TPH2‐ACE2 (yellow) positive neurons in RMG of air and CIE mice. Scale bar = 50 μm. Graph showing (G) % immunoreactive area for ACE2 and TPH2, (H) % immunoreactive area for TPH2‐ACE2 positive neurons, (I) Pearson correlation coefficient for TPH2‐ACE2 colocalization (J) Mander's overlap coefficient for TPH2‐ACE2 colocalization in RMG. Values ( n = 4 to 5/group) are represented as mean (±SEM) and the data were analyzed by unpaired Student's t ‐test with Welch's correction (* p < 0.05, ** p < 0.01 vs. air control).

Article Snippet: TPH2 , Primary , NB100‐7455 , Novus Biologicals , 1:1000.

Techniques: Control

Effect of chronic intermittent EtOH (CIE) exposure on the ACE2‐TPH2 immunoreactivity in raphe obscurus (ROB) and ADAM17, TMPRSS2, and Cathepsin L expression in medullary raphe. Representative confocal images showing (A, D) TPH2 (green) (B, E) ACE2 (red) (C, F) TPH2‐ACE2 (yellow) positive neurons in ROB of air control and CIE mice. Scale bar = 50 μm. Graph showing (G) % immunoreactive area for ACE2 and TPH2, (H) % immunoreactive area for TPH2‐ACE2 positive neurons, (I) Pearson correlation coefficient for TPH2‐ACE2 colocalization (J) Mander's overlap coefficient for TPH2‐ACE2 colocalization in ROB. (K) Representative Western blot (WB) and histogram showing the cACE2 and sACE2 protein levels in the medullary raphe. (L) Histogram showing the ACE2, TMPRSS2, ADAM17, and Cathepsin L mRNA levels in the medullary raphe. Values ( n = 4 to 5/group for IF and n = 7 to 8/group for WB and RT‐qPCR) are represented as mean (±SEM) and the data were analyzed by unpaired Student's t ‐test with Welch's correction (* p < 0.05, ** p < 0.01 vs. air control).

Journal: Alcoholism, Clinical and Experimental Research

Article Title: Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV ‐2 neuroinvasion

doi: 10.1111/acer.15000

Figure Lengend Snippet: Effect of chronic intermittent EtOH (CIE) exposure on the ACE2‐TPH2 immunoreactivity in raphe obscurus (ROB) and ADAM17, TMPRSS2, and Cathepsin L expression in medullary raphe. Representative confocal images showing (A, D) TPH2 (green) (B, E) ACE2 (red) (C, F) TPH2‐ACE2 (yellow) positive neurons in ROB of air control and CIE mice. Scale bar = 50 μm. Graph showing (G) % immunoreactive area for ACE2 and TPH2, (H) % immunoreactive area for TPH2‐ACE2 positive neurons, (I) Pearson correlation coefficient for TPH2‐ACE2 colocalization (J) Mander's overlap coefficient for TPH2‐ACE2 colocalization in ROB. (K) Representative Western blot (WB) and histogram showing the cACE2 and sACE2 protein levels in the medullary raphe. (L) Histogram showing the ACE2, TMPRSS2, ADAM17, and Cathepsin L mRNA levels in the medullary raphe. Values ( n = 4 to 5/group for IF and n = 7 to 8/group for WB and RT‐qPCR) are represented as mean (±SEM) and the data were analyzed by unpaired Student's t ‐test with Welch's correction (* p < 0.05, ** p < 0.01 vs. air control).

Article Snippet: TPH2 , Primary , NB100‐7455 , Novus Biologicals , 1:1000.

Techniques: Expressing, Control, Western Blot, Quantitative RT-PCR