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alas1 antibody  (Bio-Techne corporation)


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    Bio-Techne corporation alas1 antibody
    Alas1 Antibody, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 91/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alas1 antibody/product/Bio-Techne corporation
    Average 91 stars, based on 5 article reviews
    alas1 antibody - by Bioz Stars, 2026-04
    91/100 stars

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    Figure 1. Markers of ADC and SCC, as well as heme pathway proteins, increase with lung tumorigenesis. A, Repre- sentative H&E images of lung tissue sections from KLLuc mice sacrificed at 4, 6, 8, and 10 weeks after the induc- tion of lung tumorigenesis via viral infection. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the ADC and SCC markers, NKX2-1 and DNp63, respectively. White and blue rectangles in DAPI montage images denote ADC and SCC regions shown in 10, respectively. C, Representa- tive H&E and IHC images of lung tissue sections from KLLuc mice show- ing levels of the heme biosynthetic enzyme <t>ALAS1.</t> D, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the heme transporter SLC48A1. Shown in C and D are mon- tage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2), or antibodies against the indicated pro- tein (row 3), and 10 images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light blue lines in H&E montage images outline the tumors in the lung. The blue rectangles in H&E montage images denote the regions shown in 10.The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10. Scale bar, montage, 1 mm; 10, 100 mm. E, Graph showing quantified tumor lesion areas correlating with A. F, Graph showing quantified levels of NKX2-1 correlating with B. G, Graph showing quantified levels of DNp63 correlating with B. H, Graph showing quantified levels of ALAS1 correlating with C. I, Graph showing quantified levels of SLC48A1 correlating with D. Protein levels were quantified, and data are plotted as mean SEM.
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    Figure 1. Markers of ADC and SCC, as well as heme pathway proteins, increase with lung tumorigenesis. A, Repre- sentative H&E images of lung tissue sections from KLLuc mice sacrificed at 4, 6, 8, and 10 weeks after the induc- tion of lung tumorigenesis via viral infection. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the ADC and SCC markers, NKX2-1 and DNp63, respectively. White and blue rectangles in DAPI montage images denote ADC and SCC regions shown in 10, respectively. C, Representa- tive H&E and IHC images of lung tissue sections from KLLuc mice show- ing levels of the heme biosynthetic enzyme <t>ALAS1.</t> D, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the heme transporter SLC48A1. Shown in C and D are mon- tage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2), or antibodies against the indicated pro- tein (row 3), and 10 images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light blue lines in H&E montage images outline the tumors in the lung. The blue rectangles in H&E montage images denote the regions shown in 10.The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10. Scale bar, montage, 1 mm; 10, 100 mm. E, Graph showing quantified tumor lesion areas correlating with A. F, Graph showing quantified levels of NKX2-1 correlating with B. G, Graph showing quantified levels of DNp63 correlating with B. H, Graph showing quantified levels of ALAS1 correlating with C. I, Graph showing quantified levels of SLC48A1 correlating with D. Protein levels were quantified, and data are plotted as mean SEM.
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    Figure 1. Markers of ADC and SCC, as well as heme pathway proteins, increase with lung tumorigenesis. A, Repre- sentative H&E images of lung tissue sections from KLLuc mice sacrificed at 4, 6, 8, and 10 weeks after the induc- tion of lung tumorigenesis via viral infection. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the ADC and SCC markers, NKX2-1 and DNp63, respectively. White and blue rectangles in DAPI montage images denote ADC and SCC regions shown in 10, respectively. C, Representa- tive H&E and IHC images of lung tissue sections from KLLuc mice show- ing levels of the heme biosynthetic enzyme ALAS1. D, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the heme transporter SLC48A1. Shown in C and D are mon- tage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2), or antibodies against the indicated pro- tein (row 3), and 10 images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light blue lines in H&E montage images outline the tumors in the lung. The blue rectangles in H&E montage images denote the regions shown in 10.The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10. Scale bar, montage, 1 mm; 10, 100 mm. E, Graph showing quantified tumor lesion areas correlating with A. F, Graph showing quantified levels of NKX2-1 correlating with B. G, Graph showing quantified levels of DNp63 correlating with B. H, Graph showing quantified levels of ALAS1 correlating with C. I, Graph showing quantified levels of SLC48A1 correlating with D. Protein levels were quantified, and data are plotted as mean SEM.

    Journal: Molecular Cancer Research

    Article Title: Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

    doi: 10.1158/1541-7786.mcr-21-0385

    Figure Lengend Snippet: Figure 1. Markers of ADC and SCC, as well as heme pathway proteins, increase with lung tumorigenesis. A, Repre- sentative H&E images of lung tissue sections from KLLuc mice sacrificed at 4, 6, 8, and 10 weeks after the induc- tion of lung tumorigenesis via viral infection. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the ADC and SCC markers, NKX2-1 and DNp63, respectively. White and blue rectangles in DAPI montage images denote ADC and SCC regions shown in 10, respectively. C, Representa- tive H&E and IHC images of lung tissue sections from KLLuc mice show- ing levels of the heme biosynthetic enzyme ALAS1. D, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the heme transporter SLC48A1. Shown in C and D are mon- tage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2), or antibodies against the indicated pro- tein (row 3), and 10 images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light blue lines in H&E montage images outline the tumors in the lung. The blue rectangles in H&E montage images denote the regions shown in 10.The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10. Scale bar, montage, 1 mm; 10, 100 mm. E, Graph showing quantified tumor lesion areas correlating with A. F, Graph showing quantified levels of NKX2-1 correlating with B. G, Graph showing quantified levels of DNp63 correlating with B. H, Graph showing quantified levels of ALAS1 correlating with C. I, Graph showing quantified levels of SLC48A1 correlating with D. Protein levels were quantified, and data are plotted as mean SEM.

    Article Snippet: The dilutions were 1:100 DeltaNp63 (Abcam cat. D ow nloaded from http://aacrjournals.org/m cr/article-pdf/20/1/139/3015029/139.pdf by guest on 20 February 2024 #ab172731, RRID:AB_2891015), 1:100 TTF-1 (Agilent cat. #M3575, RRID:AB_2877699), 1:200 Ki-67 (Cell Signaling Technology cat. #12202, RRID:AB_2620142), 1:200 cleaved caspase-3 (Cell Signaling Technology cat. #9661, RRID:AB_2341188), 1:100 Alas1 (Novus cat. #NB100-56415, RRID:AB_837550), 1:200 SLC48A1 (Novus cat. #NBP1-91563, RRID:AB_11009875), 1:50 HCCS (Abcam cat. #ab224321, RRID:AB_2891018), 1:200 cytochrome c (Novus cat. #NBP2-21569, RRID:AB_2891022), 1:100 COX5A (Abcam cat. #ab110262, RRID:AB_10861723), 1:500 COX5B (Abcam cat. #ab180136, RRID:AB_2891023), 1:500 COX7B (Abcam cat. #ab137094, RRID:AB_2891024), 1:1,000 ATP5A (Abcam cat. #ab14748, RRID:AB_301447), 1:200 SLC2A1 (Abcam cat. #ab40084, RRID:AB_2190927), 1:500 HK2 (Thermo Fisher Scientific cat. #PA529326, RRID:AB_2546802), 1:200 SLC1A5 (Abcam cat. #ab58690, RRID:AB_943478), 1:200 GLS (Abcam cat. #ab156876, RRID: AB_2721038), 1:35 VEGFA (Abcam cat. #9570, RRID: AB_308723), 1:50 VEGFR1 (Abcam cat. #ab2350, RRID:AB_303000), 1:200 HIF1a (Novus Biologicals cat. #NB100-449, RRID: AB_10001045), 1:200 CA9 (Novus biologicals cat. #NB100-417, RRID:AB_ 10003398), 1:200 CD34 (Abcam cat. #ab185732, RRID:AB_2811308), and CD31 (PECAM1; Cell Signaling Technology cat. #77699, RRID: AB_2722705).

    Techniques: Infection, Staining

    Figure 4. The levels of representative metabolic proteins and enzymes in ADC and SCC tumors developed in KLLuc mice. A, Representative IHC images of lung tissue sections showing levels of glucose transporter SLC2A1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. B, Representative IHC images of lung tissue sections showing levels of glutamine transporter SLC1A5, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. C, Representative IHC images of lung tissue sections showing levels of ALAS1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. D, Representative IHC images of lung tissue sections showing levels of SLC48A1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. E, Representative IHC images of lung tissue sections showing levels of COX5A, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. Shown are montage and 10 images of lung tissue sections stained with DAPI (row 1), antibodies to NKX2-1 or DNp63 (row 2), antibodies to the indicated protein (row 3), and merged images of NKX2-1 or DNp63 with the indicated protein (row 4). The light green lines in DAPI montage images outline the tumors in the lung. The white arrows denote the regions shown in 10 images. Scale bar, montage, 1 mm; 10, 100 mm. F, Graph showing quantified levels of SLC2A1 in ADC and SCC tumors correlating with A. G, Graph showing quantified levels of SLC1A5 in ADC and SCC tumors correlating with B. H, Graph showing quantified levels of ALAS1 in ADC and SCC tumors correlating with C. I, Graph showing quantified levels of SLC48A1 in ADC and SCC tumors correlating with D. J, Graph showing quantified levels of COX5A in ADC and SCC tumors correlating with E. Protein levels were quantified, and data are plotted as mean SEM.

    Journal: Molecular Cancer Research

    Article Title: Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

    doi: 10.1158/1541-7786.mcr-21-0385

    Figure Lengend Snippet: Figure 4. The levels of representative metabolic proteins and enzymes in ADC and SCC tumors developed in KLLuc mice. A, Representative IHC images of lung tissue sections showing levels of glucose transporter SLC2A1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. B, Representative IHC images of lung tissue sections showing levels of glutamine transporter SLC1A5, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. C, Representative IHC images of lung tissue sections showing levels of ALAS1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. D, Representative IHC images of lung tissue sections showing levels of SLC48A1, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. E, Representative IHC images of lung tissue sections showing levels of COX5A, along with the ADC marker NKX2-1 and the SCC marker DNp63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. Shown are montage and 10 images of lung tissue sections stained with DAPI (row 1), antibodies to NKX2-1 or DNp63 (row 2), antibodies to the indicated protein (row 3), and merged images of NKX2-1 or DNp63 with the indicated protein (row 4). The light green lines in DAPI montage images outline the tumors in the lung. The white arrows denote the regions shown in 10 images. Scale bar, montage, 1 mm; 10, 100 mm. F, Graph showing quantified levels of SLC2A1 in ADC and SCC tumors correlating with A. G, Graph showing quantified levels of SLC1A5 in ADC and SCC tumors correlating with B. H, Graph showing quantified levels of ALAS1 in ADC and SCC tumors correlating with C. I, Graph showing quantified levels of SLC48A1 in ADC and SCC tumors correlating with D. J, Graph showing quantified levels of COX5A in ADC and SCC tumors correlating with E. Protein levels were quantified, and data are plotted as mean SEM.

    Article Snippet: The dilutions were 1:100 DeltaNp63 (Abcam cat. D ow nloaded from http://aacrjournals.org/m cr/article-pdf/20/1/139/3015029/139.pdf by guest on 20 February 2024 #ab172731, RRID:AB_2891015), 1:100 TTF-1 (Agilent cat. #M3575, RRID:AB_2877699), 1:200 Ki-67 (Cell Signaling Technology cat. #12202, RRID:AB_2620142), 1:200 cleaved caspase-3 (Cell Signaling Technology cat. #9661, RRID:AB_2341188), 1:100 Alas1 (Novus cat. #NB100-56415, RRID:AB_837550), 1:200 SLC48A1 (Novus cat. #NBP1-91563, RRID:AB_11009875), 1:50 HCCS (Abcam cat. #ab224321, RRID:AB_2891018), 1:200 cytochrome c (Novus cat. #NBP2-21569, RRID:AB_2891022), 1:100 COX5A (Abcam cat. #ab110262, RRID:AB_10861723), 1:500 COX5B (Abcam cat. #ab180136, RRID:AB_2891023), 1:500 COX7B (Abcam cat. #ab137094, RRID:AB_2891024), 1:1,000 ATP5A (Abcam cat. #ab14748, RRID:AB_301447), 1:200 SLC2A1 (Abcam cat. #ab40084, RRID:AB_2190927), 1:500 HK2 (Thermo Fisher Scientific cat. #PA529326, RRID:AB_2546802), 1:200 SLC1A5 (Abcam cat. #ab58690, RRID:AB_943478), 1:200 GLS (Abcam cat. #ab156876, RRID: AB_2721038), 1:35 VEGFA (Abcam cat. #9570, RRID: AB_308723), 1:50 VEGFR1 (Abcam cat. #ab2350, RRID:AB_303000), 1:200 HIF1a (Novus Biologicals cat. #NB100-449, RRID: AB_10001045), 1:200 CA9 (Novus biologicals cat. #NB100-417, RRID:AB_ 10003398), 1:200 CD34 (Abcam cat. #ab185732, RRID:AB_2811308), and CD31 (PECAM1; Cell Signaling Technology cat. #77699, RRID: AB_2722705).

    Techniques: Marker, Infection, Staining